Basic Information

Gene Symbol
-
Assembly
GCA_942486075.2
Location
CALNXM020000161.1:193918-194968[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.0014 0.069 13.9 4.4 1 23 115 138 115 138 0.95
2 7 1.9e-06 9.2e-05 22.9 1.2 1 23 145 168 145 168 0.98
3 7 0.0004 0.019 15.6 0.1 1 23 173 195 173 195 0.97
4 7 0.00018 0.0088 16.7 0.5 1 23 201 224 201 224 0.91
5 7 0.00023 0.012 16.3 1.6 1 23 230 252 230 252 0.99
6 7 2.1e-06 0.0001 22.8 1.4 3 23 260 280 259 280 0.97
7 7 0.0038 0.18 12.5 1.4 1 23 286 309 286 309 0.97

Sequence Information

Coding Sequence
ATGAATTTACGCAAACCATTAACGCTCAAACAATGGGATGACAATACTTCGAAATTCATCGATGCTTACGCAAAATGCCCACTTTTATACGACGGAGAGCATCCATTGTATGGAAATTTCGAGGAAATACAAAAAGCCAATCACGACCTTACAAATGCACTATTAACTGAACACAATATTGATTTAAAAGATGAAACCCTATCGACGGCAATCAGTCAATTGCATTCTTGGTATTACGATGCCAAACAACGGAAAGGAAAACAAAACGGTAGATTGAATAAGGACGAAGAGGAATATTTCAAAAAGTGTAGCTTTTTGCCAGCAAAACGTTTAAAAACGAAATTTTATTGTAACATTTGCAAGAAAAATTTCAACATGGAACACAATCTAAAGGGTCATCTCTTTAGATTCCATCAGATAGGAGACCTACCCTTCCAATGCGACCAATGTGGCAAAAAATTCGAAATCAAATCCACCCTACAAACTCACATTCAAAGAATGCACGTCAGTAGGAAATTCCCTTGCGGTTTCTGCGGAAAACTCTTTGCCATAAAATCGGAGCTAAAAGTTCACAATATGGTACACACAGCGGAAAAGCCACATGTCTGCGAACTGTGCGGAAAAGCGTTTAGAATAAAGACACAACTACGCTACCATGTTACAGCAATACACACAAAGATTCGTGCCTACAAATGTACCATGTGCCCCAAGGATTTCCTTAAGAAACGTGACTTGACCGATCACGTTAAAACGCACCTGAATATTCGCGACAAGATATGTGAAACGTGTGGAAAGGGCTTTTCGAACAGTCATTCGTTAATTCGACATCGTCAAATACATTCGGAAGTAAAGCGATACGCCTGTAAATTGTGCGATGCCAAGTTTCACCAATTTGTCGGTCTAAACGGTCACATGAAACGTACGCACAACATTGTAAAAAAAGATTCATAA
Protein Sequence
MNLRKPLTLKQWDDNTSKFIDAYAKCPLLYDGEHPLYGNFEEIQKANHDLTNALLTEHNIDLKDETLSTAISQLHSWYYDAKQRKGKQNGRLNKDEEEYFKKCSFLPAKRLKTKFYCNICKKNFNMEHNLKGHLFRFHQIGDLPFQCDQCGKKFEIKSTLQTHIQRMHVSRKFPCGFCGKLFAIKSELKVHNMVHTAEKPHVCELCGKAFRIKTQLRYHVTAIHTKIRAYKCTMCPKDFLKKRDLTDHVKTHLNIRDKICETCGKGFSNSHSLIRHRQIHSEVKRYACKLCDAKFHQFVGLNGHMKRTHNIVKKDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01374383;
90% Identity
iTF_00259206; iTF_00259931;
80% Identity
iTF_00259931;