Cvom007523.1
Basic Information
- Insect
- Calliphora vomitoria
- Gene Symbol
- pax6a
- Assembly
- GCA_942486075.2
- Location
- CALNXM020000158.1:132172-170524[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2e-35 5.2e-32 110.6 0.0 8 125 11 127 6 127 0.90
Sequence Information
- Coding Sequence
- ATGCCGCATACAATAGTAACTCCGCCATCATTGAATGGGGTTTTTACCAACGGGCCGCCAGCGATATCTTTAAGTACACTCGCCTCCCAAAATAGACTATTGGAACTGTCACGCTTTGGACTTCGTGGTTATGATTTAGCTCAGCATTTGCTTTCCCAACAAAATGCAGTTTCTAAACTACTAGGTACGCTGAGACCACCTGGATTAATTGGAGGATCAAAACCAAAAGTTGCTACCCCAGCTGTTGTATCAAATATTGAACAATATAAACGTGAGAACCCTACAATATTTGCGTGGGAAATTCGAGAGCGACTGATATCTGAAGGTGTTTGTACGAATGCCACAGCACCATCAGTATCATCAATAAATAGAATTCTACGAAATAGAGCTGCAGAAAGAGCTGCTGCAGAATTTGCACGTGCCGCTAGTTATGGCTACATGAATCCGCAACTTCCATATGCAAGTTTCCCAACATGGCCAACACCATTACCGACAGCACATCAATTGTGGCATCCAAGTACCAATCAGAATGTAATTTTAGAAAAACATATCGATAAAACAGGTATTGATCAGAGCCATTTAAATATTTCACTTACTGGAACATCACCAACATCTAGTGGACATGACACAATAGGATCTCCAGAAGCCAACAGAATGATTGATATTGAAGGTGAGGATTCAGATTCGGATGATAGTGATCAACCAAAATTTCGACGTAATCGAACAACATTTAGTCCCGATCAACTGGAGGAGCTGGAAAAAGAATTTGAAAAGTCACACTATCCATGCGTAAACACACGGGAAAAGTTGGCATCCCGCACATCTCTTAGCGAAGCAAGAGTTCAGGTTTGGTTTTCCAACAGAAGAGCGAAATGGCGGCGACATCAGCGTGTGAATCTATTAAGGAAAAGGGGCTCAATATCACCACAAAATCATTCCTCTCCAATAAATTTCTCAACGGAAACGCATTTCTCCCACAAACTGCCACAGATACTGTCAAGAATAACGGGAGTCGACAGTTCATTGGAACCAATGAATCTGAACCAACATCAAACTCTCCTATATCCAACATATCAATGTGTGGAGAACTCAATGTACCACGACATCGGCGAAAAAACAGTGAAGCCGACAGCGCCAGTTTTAAGCATTACTCCCATCCATATCGAAAAACCACCTATAGCGGAATCGAACAACAAAAGTCCAAACCGCCAGCAGAGACTAATAATGGATGCAATGCTATCATCACACACAGCATCAGTTCCATTATTAATGGGAGGTGAAAATAGTGCGTTTAAATCCATAAACATCCACCCACCAGGCTCGGCTAGAGCTCTCGCCAAGAATGATACTTCACAATATCTGGACTCATCCACATCGGAAATCAGTGCAAACCAACCCGTAAACCAAAAACATAAAACCACGATGGCCGGCGCACCATCATCACTTAAAAAATTTGCATCAATTACAATTAATAGTAAGACGAACGGAAGTAATAGTGACAATGACCGTGATAGTGCTAGTGACGTAGAAAACGTTAAGAATAATAAAAACAGTAATAATAATAATAATAATAATAATAATAGATTTAATAATGATACAAATAATAATATTCACACAATTTAG
- Protein Sequence
- MPHTIVTPPSLNGVFTNGPPAISLSTLASQNRLLELSRFGLRGYDLAQHLLSQQNAVSKLLGTLRPPGLIGGSKPKVATPAVVSNIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERAAAEFARAASYGYMNPQLPYASFPTWPTPLPTAHQLWHPSTNQNVILEKHIDKTGIDQSHLNISLTGTSPTSSGHDTIGSPEANRMIDIEGEDSDSDDSDQPKFRRNRTTFSPDQLEELEKEFEKSHYPCVNTREKLASRTSLSEARVQVWFSNRRAKWRRHQRVNLLRKRGSISPQNHSSPINFSTETHFSHKLPQILSRITGVDSSLEPMNLNQHQTLLYPTYQCVENSMYHDIGEKTVKPTAPVLSITPIHIEKPPIAESNNKSPNRQQRLIMDAMLSSHTASVPLLMGGENSAFKSINIHPPGSARALAKNDTSQYLDSSTSEISANQPVNQKHKTTMAGAPSSLKKFASITINSKTNGSNSDNDRDSASDVENVKNNKNSNNNNNNNNNRFNNDTNNNIHTI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00259599;
- 90% Identity
- iTF_00259599;
- 80% Identity
- iTF_00259599;