Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_002245475.1
Location
NJDC01001001.1:61876-87548[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 8.8e-16 6.1e-12 45.6 0.0 5 66 773 833 769 849 0.91
2 2 2.1 1.5e+04 -3.7 0.0 44 67 1141 1162 1139 1163 0.83

Sequence Information

Coding Sequence
ATGGCTGTAAAAACTTGTTGTATAGAAACCTGTCAGTCCTCTGCTACTCGGCCAGAGGATGTTGGGGTTACTTTTCACAAGTTCCCAAAGAACTTGCTTCGAGAACGCTGGCGATCTGTTACTCAGTTTAAAAGGAATATTGATTCCCAAACTTATGTTTGTTCAAGGCATTTCTGTAAAAATGACTTTAGATTATATGATGgctcaaaatatgttttgaaaaCAGaTGCAACACCATCAATATTTTCTTGGACAAAagataaaacaacaaataaaaaaatggattatGATATATTTAATGATAATCCTGAGGAACAAATTAATACATCCTCAAGTAGCAAGGAGTCTGACGTTCAAAATGTTGAAGCCATACAAAAGTTCATTGAAGATCAAGAGAAAGAATTAAACAAATCTTCAGAAATTTATGAAAAACCTGAAAGTAATgatgtaaaacaaaacaatgaatCTCAAAATGAAATGATAGATGTTAGTCACCACCAAGAACCTGTGTCTATTAGCACAGTGGCTTCTATGAGTACAAGTGTGATGAACATGATTTTAAGTGAGCCTGAAACTAAAATGGCACCCATAGACGACAAACCTTTACCTAAACACATTGGTAGCGCAGGAGAAAAAGGTAACAGTGTTGCCCTAACGGTTGGCTCAGAAGTGGAAGCGAAAGATTATGCAGGAGTCTGGCATGCAGCAAAGATCGTAGAAGTGGACTATGATGAAATGGAGGTATTGGTCCACTATGAAGATGTTTTATGCAGATCTGATGAATGGATTACCGTGAATAGCACAAGACTTAGACCAATTAGTGCTAAACCTTTAAATGACACAGTAGATAGTCCTTCAACATCGACCATAGCTGCGAATGCAACTGTGCCTTGTGTAAAGACAGCTAAAGAAGAAATGGGTGAAGACAAGTCGAAAGTAACGTACTCTATCGGAGAACGGTGCTTAGCGCGGTGGAGAGACAATCGGAGATTTGAAGCTACTATAACCAAGGAACTGGAAAATgGTGAATATGAAGTAGTATTTGACGATGGTTTTCAATGGAAATGTACTACCTCAAGgctttataaatacaaaaaatcctCTAAAGTTGGCGATCTTAGCGTTGATACAACCATGTCCCCTTCAACATCTTCGCCGTCCCCTGTTTTGCCTGGAGTTGGTCCAAGCACAGGGGTGTCTGGTGCTCTAAATCCTCCTTTCCATACTCATTTATTTGATCCCACTCGTGACTATTTGAGCTCAAAGACAGAACGTCGcgaaatgaaaagaaaactaaacattaaagaaatattCAATATCGGTCAGAAGAAGAAAAGAATATCGACTACACCGCCAGTGAAAAGAGCACCAGTTGTAAGAGAGAAACGTAAACGTAAGCGGGGGAAAAAAAGGATTAAACAGGAACCAGAGGAAGACGCTACTATTAAAGAAGAAACTAAAGAGCTtcctgATGCTGTGGCTTCCATAATAGGGACTGTTGCTAAGTCTGAGGATATGACAAAAGACTTGATTGAACCTCACGAGTTAGGTATAAAGAAAGAACCAGAAGACCTAGCAAGTCCAGATATAAGTGAACCGTTACATGACAGTGGTGAAATCTTACTTACGAAAAAAGAACCAATGGATATCACATCCGATCTTAGCTTATCCAACAATTCAGAGGAACAAAATGCTAGCGCCACGATTGAACCTGCCAGCGAGGAAGAGAGTAAATTagagaaatttgaaaaaccagaTGAAACTAAACATGAAAAAGTAATGGACAAGTTTAAAGAAGTTATAAATAAGTTAGAGGTTGGattgaatgaaattgaaaaagttAGCTCACCTAAAGTAGAAATTAAATGCCAGACATTGGAACCAATAGTTGTGGAACCTCCTCTATTGGTTcctaaagaagaagaaaagccATTGGTTTCTCCCGAAACTGTCCTGCTAGCTGCCCccgtaaaagaaataaaagaggacactgaaaaacaaaagaaaaaattatctaagattaaaaagacaaaaaaattgcgtttgttacaagaaaagaaagtaaaaagaCAAGTGGAGAAAGTGAAGAGTGAATTAGAGGAGATGAAGCGCCAAGTTGAAGAGATGAAGAAacagatgatgatgaagactgAGGAGCTATCGAAACAAACACCTCAGGAAATGCCTGAGAATTTTCTATTGCCCGGAGAGTGGTGCTGTAAGTGGATTAATGGCCAACCCGTGGGAACTGTATGTGAATTGGAAACAGAAGTCAAAGATGCAAATAATAAGCCAGCTCTTCCACGACGTAGTGTACAGgTGGAAGACAAAAGGCTGCCTCCCGGCTGGACGAAACACATGGTTCGCAGGAGTTTTGGTCAGTCGGCAGGGAAATGGGATGTTGTTTTAATCGGgCCAGACAACCATCGTTTCCATACAAAAACCGATATGAGAAATTACCTGGATCTCCATCCAGAACAAAATCTAAGGCCCTACGAGCATGCCTTGTTAGATTTTGGGGTTCATTTGAAGCTTTCGAGACGTATGGGCTGGTTTAAAACTGTCAGCGGAGAAGTAGCTCAGCCTACTGGCATAATAGATAGCTTATCACCATTAGTCAAGCGAAAAAGTTTAAGCCTTAAAAGGAAAGGACCAAGAAAGGAAAAGCCAAAGCTGAAGAAATTTTCGAAGCGTAACtttttaaaggtGCCGGAAGATGACCCCAGTGATGTATTTGATACATCTGAAAACGCCAACGATATGTCGTATGATCAGCCAACGTTGGAAGATGGCTATGTGTATGTTGGTTCATTGAAAGTTCAAGTAATTGAAAATCTTCTTCGATGTCCAGCTGAAGGTTGTTTTAAGAACTTtagaaataatacattattaaaaatgcacataaAACATTATCACAGAGAACTGAGAAAATTATTGGGAGTAACTCCTAAAGTGTTGGACCTAGCGTACGCTAGATCAAAAACAAAACCTACTGATAAGAAACCAAAAAAGGTACGACGTGATCCGATGTCTAAGgttataaaagtgaaaatacCCAGAATACACAAACGTGTTGAAGAACCGATGCCAGTTGCACCTGATGTACCTATAGAACCGACTGTACCTCCAGTACCAAAGATAGGAAGGATCATACCGAGATCTCAAGATTCCCCGAAGCTTCGACAAGCTTTGGCCAATAGCAATAAACCGGTAAAACGTCCTAAAGTACTTCTACCAGTCAGAAGACCAGATCCACCGGACATAGCCTCAGAAATGGACGAACCGCCTTTAATGGACTTCGAGGATGTAGATTTAGATAACTCAGAAATCCCAATGCCATTGGATTTCGAATCTGCAATATCTACCCATACTGTAACAAAACCACCATTAGATGAGCCAAAAAAACCTGAGAGTAAAAAGAAGTCAATGAGTGAGACAGAAGAGTGGTTGGCTGTGAACTCGGATTTCGAGACTAGATCCAGTTTTCCAGGATCGGGGACACCGGATTCGAAGTCGCGACATGACAATGATAAACCCTTGAGTAACAATCCTGGCGTTTCTTCAGAGTCTAATGAGGATAAGGAAGTCCCCGAGAAGTACACGTGCAGCATCTGCCTGAACCCGCGGCGCGGGCGGCGCTCGATGCGGTTCCTGCACGACCAGGACCGGCTCTACGAGGGGCTGCTGCCGGGCGCGCGCCCCTCCGACTGCCTGCGGCGCTCGCACGAGCTCTCCGGCAACCTGCTGAGGATACAGGACGCGCTGCACGCTCTAAGGGTCAAGTACAACGTCGCCTCaaaTCGAAATCACCCAAAACTGTATCTTTGGGCAAAAGATTGGGAAAGCGCAGAAGTAAATATGACTCAAGAGAAACTTAACTCAGACTACTCCGATTTGAATATAATCATAAACAACATTGGCAAAGAAAATTTGCCGGTGAGAGCCGAAGATTTACGGGATTTGAATTTAGATGCGAGGACGACTCCATGCGATGATGACAATAGGGACCCGCAGTTGATGAGCTTGGCCAACGCCCTCTCGAGTCCAGGTGGGACTTCCTTAGACTTGCCTATCTCTACATCAGAGTTGGAACGGCTGGCGAAATCTGTTCAAGAGCAAGAGAGCGGCGTGTCTGGCGTGTCTGGTGTGTCTGGGGTGTCCGGGGTGTCGGGCCCGCAGCCGGAGCCGGCCATCGAGAGCGGCGCGTGTCGCGAGCGGCTGCTGCGACACGTGCGCCGGTGTCAGGCGCTCATCGACGCCAGGCTCGACTCCATCGAGGCCCAGGTTGCAGAATTGGAATCTCAAGACCCATCGTTCGAAGATGACGAAACAGCAGACTATTTCCCTCGAACGAAACAAACCATACAAATGTTGATGCGCGATCTGGACACCATGGAAGAGCTTGGAACGATTACATAG
Protein Sequence
MAVKTCCIETCQSSATRPEDVGVTFHKFPKNLLRERWRSVTQFKRNIDSQTYVCSRHFCKNDFRLYDGSKYVLKTDATPSIFSWTKDKTTNKKMDYDIFNDNPEEQINTSSSSKESDVQNVEAIQKFIEDQEKELNKSSEIYEKPESNDVKQNNESQNEMIDVSHHQEPVSISTVASMSTSVMNMILSEPETKMAPIDDKPLPKHIGSAGEKGNSVALTVGSEVEAKDYAGVWHAAKIVEVDYDEMEVLVHYEDVLCRSDEWITVNSTRLRPISAKPLNDTVDSPSTSTIAANATVPCVKTAKEEMGEDKSKVTYSIGERCLARWRDNRRFEATITKELENGEYEVVFDDGFQWKCTTSRLYKYKKSSKVGDLSVDTTMSPSTSSPSPVLPGVGPSTGVSGALNPPFHTHLFDPTRDYLSSKTERREMKRKLNIKEIFNIGQKKKRISTTPPVKRAPVVREKRKRKRGKKRIKQEPEEDATIKEETKELPDAVASIIGTVAKSEDMTKDLIEPHELGIKKEPEDLASPDISEPLHDSGEILLTKKEPMDITSDLSLSNNSEEQNASATIEPASEEESKLEKFEKPDETKHEKVMDKFKEVINKLEVGLNEIEKVSSPKVEIKCQTLEPIVVEPPLLVPKEEEKPLVSPETVLLAAPVKEIKEDTEKQKKKLSKIKKTKKLRLLQEKKVKRQVEKVKSELEEMKRQVEEMKKQMMMKTEELSKQTPQEMPENFLLPGEWCCKWINGQPVGTVCELETEVKDANNKPALPRRSVQVEDKRLPPGWTKHMVRRSFGQSAGKWDVVLIGPDNHRFHTKTDMRNYLDLHPEQNLRPYEHALLDFGVHLKLSRRMGWFKTVSGEVAQPTGIIDSLSPLVKRKSLSLKRKGPRKEKPKLKKFSKRNFLKVPEDDPSDVFDTSENANDMSYDQPTLEDGYVYVGSLKVQVIENLLRCPAEGCFKNFRNNTLLKMHIKHYHRELRKLLGVTPKVLDLAYARSKTKPTDKKPKKVRRDPMSKVIKVKIPRIHKRVEEPMPVAPDVPIEPTVPPVPKIGRIIPRSQDSPKLRQALANSNKPVKRPKVLLPVRRPDPPDIASEMDEPPLMDFEDVDLDNSEIPMPLDFESAISTHTVTKPPLDEPKKPESKKKSMSETEEWLAVNSDFETRSSFPGSGTPDSKSRHDNDKPLSNNPGVSSESNEDKEVPEKYTCSICLNPRRGRRSMRFLHDQDRLYEGLLPGARPSDCLRRSHELSGNLLRIQDALHALRVKYNVASNRNHPKLYLWAKDWESAEVNMTQEKLNSDYSDLNIIINNIGKENLPVRAEDLRDLNLDARTTPCDDDNRDPQLMSLANALSSPGGTSLDLPISTSELERLAKSVQEQESGVSGVSGVSGVSGVSGPQPEPAIESGACRERLLRHVRRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTIQMLMRDLDTMEELGTIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00255983;
80% Identity
iTF_00256993;