Basic Information

Gene Symbol
Aef1
Assembly
GCA_035041755.1
Location
JAWNKX010000167.1:2772606-2773674[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0044 31 5.0 0.1 20 48 204 232 198 236 0.85
2 4 2.9e-05 0.21 12.0 0.0 21 51 233 263 229 264 0.88
3 4 0.0075 53 4.3 0.1 21 51 261 291 259 292 0.87
4 4 0.00025 1.8 9.0 0.1 21 47 289 315 286 322 0.88

Sequence Information

Coding Sequence
ATGATGCATATTAAAACTCTGCAACATGCACAAGCGGCTGCTGCGGCCATGAATAATAGCAATTGTGAGATCGTTATTGTATCGGCGTCTCCACAACAGACGACggcaaacaataacaatgataCCGTTACACATGCGTCGCATGCAGCGGCCGCTGTAGccgcgcagcagcagcaacaacagcatcaacagcatcagcaacaacaacaacagcagcaacaacagcagcaacaacaacaacaacaacaacaccagcaacaacaacaacatcagcaacaacaacaacagccaccaGGGCCACCTCCACCTACAGACATTGCAATTCCCTTTAATATGCACCTGACTGGTATCTCTGCAGAGGCTCATTCAGCAGCACAAGCAGCCGCAATGGCTGCGGCCCAAGCTGCAGCAGCACAGGCGGCTGCtgctgaacaacaacaacagcagtcaGGTAACATGCAACAACATTCACTTGCCCATCTCGTTGCTACGGCAACACACAGTCCGACGATTTCcgatcagcagcagcattacGTCGCCAATGGGCACAATGGAAGCGGCAGCACGTCGTCTGGTggcagtggtggtggtggcggcggcaGCGGTGATCGTCCAGAAAAACCCTTTCAGTGTAACGTCTGTGAACGGCGATTCCGGCAATTGAGTACGCTCACCAATCATGTGAAGATCCACACCGGCGAAAAACCATACAAATGCAATGTGTGTGATAAAACTTTCCGTCAATCGTCTACGCTTACAAACCATCTTAAGATTCATACCGGTGAGAAGCCGTACAATTGCACCTATTGCCCGAAGCATTTCCGCCAGCTAAGCACTTTGGCCAACCATCTCAAGATACACACAGGCGAAAAACCTTTCGAATGTGTGGTTTGCAAAAAACAATTCCGCCAGTCCAGTACACTTAACAATCATATAAAAATCCATGTTATGGACAAGGTCTATGTCCCTGTTAAGATCAAAACTGAGGAGGATGAGGGGTGA
Protein Sequence
MMHIKTLQHAQAAAAAMNNSNCEIVIVSASPQQTTANNNNDTVTHASHAAAAVAAQQQQQQHQQHQQQQQQQQQQQQQQQQQQHQQQQQHQQQQQQPPGPPPPTDIAIPFNMHLTGISAEAHSAAQAAAMAAAQAAAAQAAAAEQQQQQSGNMQQHSLAHLVATATHSPTISDQQQHYVANGHNGSGSTSSGGSGGGGGGSGDRPEKPFQCNVCERRFRQLSTLTNHVKIHTGEKPYKCNVCDKTFRQSSTLTNHLKIHTGEKPYNCTYCPKHFRQLSTLANHLKIHTGEKPFECVVCKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEDEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00891272;
90% Identity
iTF_00251580;
80% Identity
iTF_00251580;