Basic Information

Gene Symbol
Aef1
Assembly
GCA_016920775.1
Location
JAFDOW010000470.1:780769-786949[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0027 8.6 6.4 0.1 22 45 17 40 8 43 0.86
2 4 0.0019 5.9 6.9 0.0 21 47 44 70 42 75 0.85
3 4 0.0078 25 4.9 0.1 21 47 72 98 67 103 0.84
4 4 6.7e-05 0.22 11.5 0.1 21 51 100 130 92 133 0.87

Sequence Information

Coding Sequence
ATGTCGACACAAATATCTCCCAAAAAGATGACGATCACCAATGACCAACAAAAACCGTTTCAATGCGCCATTTGCGAGAAAACATTTCGTCAATTAAGCACACTGACAAATCACTTTAAAATCCACACAGGAGAaaagCCATTCAAATGCTCAACATGCGACAAAAAATTCCGTCAGTCCAGCACTCTAACAAACCATTCAAAAATACATACGGGAGAGAAGCCTTTTTGCTGCAATTTTTGCCATAAACCGTTTCGACAACTAAGCACACTAACTAATCACCAAAAGATTCACACCGGCGAAAAGCCGTTCGAGTGTGCCGTGTGTAAGAAGCAATTCCGTCAGTCGAGTACGCTAAACAATCACATAAAAATCCATGTGGGTGACAAGCCGTTTATGCAAGAAATGCAAGAACTACAAAATTTGCACAATCAACAGCAGCAAGGCGATCATATCCTGGCACAGCATATTGTGGTGCAAATGGAACATTCGAAAGCGGAACCAGTAAAATCGGAAGCGAGTACATGA
Protein Sequence
MSTQISPKKMTITNDQQKPFQCAICEKTFRQLSTLTNHFKIHTGEKPFKCSTCDKKFRQSSTLTNHSKIHTGEKPFCCNFCHKPFRQLSTLTNHQKIHTGEKPFECAVCKKQFRQSSTLNNHIKIHVGDKPFMQEMQELQNLHNQQQQGDHILAQHIVVQMEHSKAEPVKSEAST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01266332;
90% Identity
iTF_00246697;
80% Identity
iTF_00246697;