Basic Information

Gene Symbol
-
Assembly
GCA_016920775.1
Location
JAFDOW010000643.1:246076-249556[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 7.5e-05 0.0038 17.4 2.7 2 23 54 76 53 76 0.95
2 13 0.00052 0.026 14.8 1.1 1 23 80 103 80 103 0.97
3 13 0.00011 0.0058 16.9 1.6 1 23 121 143 121 143 0.98
4 13 6.6e-07 3.3e-05 23.9 1.8 1 23 149 172 149 172 0.97
5 13 1e-06 5.3e-05 23.3 0.6 1 23 177 199 177 199 0.98
6 13 6.3e-06 0.00032 20.8 0.7 1 23 205 227 205 227 0.98
7 13 7.8e-07 4e-05 23.7 1.5 1 23 234 256 234 256 0.99
8 13 3.9e-06 0.0002 21.5 0.4 1 23 262 284 262 284 0.98
9 13 1.9e-06 9.7e-05 22.5 2.7 1 23 290 312 290 312 0.99
10 13 9.9e-05 0.005 17.1 0.4 1 23 319 341 319 341 0.98
11 13 0.0012 0.063 13.6 0.1 1 23 347 369 347 369 0.98
12 13 0.0002 0.01 16.1 2.1 1 23 376 399 376 399 0.94
13 13 3.2e-05 0.0016 18.6 1.7 1 23 405 428 405 428 0.98

Sequence Information

Coding Sequence
ATGGCTAGCAaatcaaaaaatccaacaaaaggATTAGGACGGAACATTATCAAGGACAATGGTGTAGGGACTGCAGACGGTATGGTCGGTGGtgttcacaaaaaaaacgttAAGAAGGCTAAGTTACGTCCTAAAGCAAAGGATACCGATGGTTCCATTAGATGCGTCGTCTGCTTAGAACAATTCAAACGCAAAAGTCACTTCCAGAAGCATATGAGAGACGAACACTACAAATCGTTTGAGTGCGACATCTGTCATGGCACATTTTCCACCCTTTCGAAGATAGAATCCCACTTGATGAAAATGCATATTGCaggaaattttataaaaaaggaaattccagaTTCAAATGACAAACCGTTTATGTGTCATCAATGTCctgcatcgtttaaaatttCCAGTAAATTGAAAGGGCACATGCTAAGTCATAGTAACGATCGAGCGTTTGAATGCGAAATGTGCGATCGAAGCTTTAAACACCGAGAAAGCTTAAATAATCACATCCAAATTAATCACATGGGCAAACGTTTCATGTGTGAAATTTGTAACGCGGAGTTCACGTCAAAGTCAAATCTTGTGACCCACACGAGAATGCATAATGGCGATCGACCGTTTAGCTGCGAAATTTGTTTTGCTAACTTTGCCAAGAAAAGTAATTTAACGGTACATTTACGATCACACAACGATAGTGAGAGACCGTATGTATGTGACATCTGTGCGGCTGCGTTTAAAAATTCGTCCCACTTAACGCGTCACAAGAGAACACACAGTGAAGATCGACCTTACAAATGTACTGATTGCTTTGCTGGTTTCAAATCCCCGGATCTTCTTAAAAATCACATGAGCATCCATTCCGACGAGCGTTCATTCAAATGCGAGCTATGTTCCGCAACttttaaacagaaaaagaaTTTGAACAGCCATTTGAAAACACACTCCAAGAAGGAGAGATCTTTCCAATGCAATATGTGTACGGATGCGTTCACTTCCCAGCTTGCTCTGACTAAACATATGCTCGTACATACTACCTGTCGACCTTTCGAATGCGAAATTTGTTTGGCTAGTTTTAAAGAAGCTGGTGCAAGAATGCGTCACATGAAGATACATTTAGACGACCGAAAAATGTACGAGTGCGAAATTTGCTCTAAGAAATTCATGCATTTGTATTCGCTAAAATCTCACGAGCAACTGCTTCATCTAAAAGACAATCCGTACGAATGCAGCAAATGTAAGAAAAAGTTTGGGAATGGAAAAGCCTTACGCAGGCACCTTAAACGAATTCACAATGCTACTGAGTTGAAGGTAGCTGAACGATCTGCTGATGACACACATATCGTGAGCTTGGACAATATTAAACGGGAGCCCAAACTTTTAagttag
Protein Sequence
MASKSKNPTKGLGRNIIKDNGVGTADGMVGGVHKKNVKKAKLRPKAKDTDGSIRCVVCLEQFKRKSHFQKHMRDEHYKSFECDICHGTFSTLSKIESHLMKMHIAGNFIKKEIPDSNDKPFMCHQCPASFKISSKLKGHMLSHSNDRAFECEMCDRSFKHRESLNNHIQINHMGKRFMCEICNAEFTSKSNLVTHTRMHNGDRPFSCEICFANFAKKSNLTVHLRSHNDSERPYVCDICAAAFKNSSHLTRHKRTHSEDRPYKCTDCFAGFKSPDLLKNHMSIHSDERSFKCELCSATFKQKKNLNSHLKTHSKKERSFQCNMCTDAFTSQLALTKHMLVHTTCRPFECEICLASFKEAGARMRHMKIHLDDRKMYECEICSKKFMHLYSLKSHEQLLHLKDNPYECSKCKKKFGNGKALRRHLKRIHNATELKVAERSADDTHIVSLDNIKREPKLLS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00245638;
90% Identity
iTF_00246846;
80% Identity
iTF_00246846;