Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.094 1.7e+02 2.3 0.2 23 50 44 71 41 75 0.80

2 9 0.65 1.2e+03 -0.4 0.0 26 47 75 96 69 97 0.79

3 9 0.00054 0.97 9.5 0.3 25 49 167 191 153 194 0.82

4 9 0.0024 4.4 7.4 0.0 21 49 191 219 187 222 0.86

5 9 9.4e-05 0.17 11.9 0.1 21 52 219 250 215 255 0.90

6 9 0.2 3.5e+02 1.3 0.0 21 44 247 270 245 274 0.87

7 9 0.0028 5 7.2 0.0 21 52 275 306 271 306 0.87

8 9 7.2e-05 0.13 12.3 0.1 21 46 303 328 300 331 0.92

9 9 0.69 1.2e+03 -0.5 0.1 26 43 338 355 331 357 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.094	1.7e+02	2.3	0.2	23	50	44	71	41	75	0.80
2	9	0.65	1.2e+03	-0.4	0.0	26	47	75	96	69	97	0.79
3	9	0.00054	0.97	9.5	0.3	25	49	167	191	153	194	0.82
4	9	0.0024	4.4	7.4	0.0	21	49	191	219	187	222	0.86
5	9	9.4e-05	0.17	11.9	0.1	21	52	219	250	215	255	0.90
6	9	0.2	3.5e+02	1.3	0.0	21	44	247	270	245	274	0.87
7	9	0.0028	5	7.2	0.0	21	52	275	306	271	306	0.87
8	9	7.2e-05	0.13	12.3	0.1	21	46	303	328	300	331	0.92
9	9	0.69	1.2e+03	-0.5	0.1	26	43	338	355	331	357	0.79

Coding Sequence: atggttttcgatagGGAAAAAGGGAATGAGCATGTTGATGAGGAGGAAAGTAgtgatgacgatgatgatgatgatgatgatgacgtgACAACGTACATATATGACTTGGACCATCCTCCACCGGAGTCGAGACCATACGCCTGTCCAGTGTGTGGCAAGCGATACGTTCAAAAGTACTTTTTGATCGCTCACATGGACATTCATAACTATGAAAAGAAATTCGAGTGCTACATTTGCAAGCAATCATTTTGGCTGGAACGCGATCTATTCAAGCACATGAATACTCGCTGCGGCAGAGATGTTTCACCGGTGCATGAAATACCACCACATCGAAGAAACCCGAACGCTAAGCAGTCGGGAAGTACGGCACGAAAGAAAAAGGTGCGCGATTCAAAGCGGGATAATCAAGTTGACGGAAAGGATTGTGCTCGTCACGTAGAACGCAGCGCCGCTTCATCAAAAAGCTCGCCATCAAACATTCGACGAGAATCGAAAACTTACTCCTGTCCGGAGTGTTACAGAGAATTCAGGCACAAGAACAATTTGACCATGCATTTAAGGATCCACAGTGGGGAGAAGCCGTTTGAGTGCGGAGTTTGTAAGAAAGCTTTCAGTCAATCTAGCACTTTGACCAGCCATCTTCGGATTCATACTGgTGAAAAGCCGTTCGAGTGTGGGGTTTGTAAGAAAGCTTTCAGTCAAAGTAACCATTTGACCCGCCATCTTCGGATTCATAATGgGGAAAAGCCGTACGAGTGCGGGGTTTGTAAGAAGGCTTTCGGTCACAGTCACCATTTGATCGACCATCTCCGAACTCATACTGgGGAAAAGCCGTACGAGTGCGGGGTTTGTGACAAAGCTTTCAGTCAATCTAGCACTTTGACCAGCCATCTTCGGATTCATAATGGTGAAAAACCATTCGCATGCGACATttgcaaaaaaacatttcgacaAAAGACGCACATTCGTAAACACATGAATATTCACATTCCAAACAgTAAAAGAATTTACAAGTGCAAGGTGTGCATGAAAGTGTTCCACCAGCGACACATTCTGTCCGAGCATCGTAAGGACCATGAAGAAGAAAGTTAA
Protein Sequence: MVFDREKGNEHVDEEESSDDDDDDDDDDVTTYIYDLDHPPPESRPYACPVCGKRYVQKYFLIAHMDIHNYEKKFECYICKQSFWLERDLFKHMNTRCGRDVSPVHEIPPHRRNPNAKQSGSTARKKKVRDSKRDNQVDGKDCARHVERSAASSKSSPSNIRRESKTYSCPECYREFRHKNNLTMHLRIHSGEKPFECGVCKKAFSQSSTLTSHLRIHTGEKPFECGVCKKAFSQSNHLTRHLRIHNGEKPYECGVCKKAFGHSHHLIDHLRTHTGEKPYECGVCDKAFSQSSTLTSHLRIHNGEKPFACDICKKTFRQKTHIRKHMNIHIPNSKRIYKCKVCMKVFHQRHILSEHRKDHEEES

Sequence clustering based on sequence similarity using MMseqs2