Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.012 61 4.8 0.0 20 44 87 111 80 119 0.83

2 6 0.0005 2.5 9.2 0.0 20 52 148 180 136 182 0.86

3 6 0.098 4.9e+02 1.9 0.0 21 47 177 202 174 209 0.85

4 6 0.014 70 4.6 0.0 19 44 202 228 195 236 0.82

5 6 7.4e-05 0.37 11.9 0.0 23 52 235 264 230 266 0.84

6 6 0.26 1.3e+03 0.5 0.3 21 30 261 270 256 283 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.012	61	4.8	0.0	20	44	87	111	80	119	0.83
2	6	0.0005	2.5	9.2	0.0	20	52	148	180	136	182	0.86
3	6	0.098	4.9e+02	1.9	0.0	21	47	177	202	174	209	0.85
4	6	0.014	70	4.6	0.0	19	44	202	228	195	236	0.82
5	6	7.4e-05	0.37	11.9	0.0	23	52	235	264	230	266	0.84
6	6	0.26	1.3e+03	0.5	0.3	21	30	261	270	256	283	0.82

Coding Sequence: ATGGaagataataaaattgaaatagtAGATCATGAAATAAAGAAGGAAGATGATAAAGATTATCAAAgtaatattgaaattaaaagCGAAGAAATATGTattgataaaattaaagaagaaaaCATAATACCAATCAGACATCAAGTCTGTGTTTCCGATGAATTTAAAATTGAGACTGAAGAAATTTCTAGTGATGACGTAATCAAAGAAGAGCAGAGAGATGAAAGAGTGGAATATTGTAATGAAAAAAGTGTGATAGATAGAGAAAAACCATTTACATGCTCACTTTGTGGAAAATCTTTTAAACGGAAGGGTGATTTCAAAAGGCACAGTTTTTTACATTCAGAAATAAAATctcctaaatataaaaaatatatttgctcgATTTGTGGAAAATCTCTGGGTGATAAAAATGGTATGGAGAACCACATGCAGATACATACAGGAGAAAAGCCGTTTATATGCTCATTCTGTGGAAAATCATTTAGACAAAATGCTGATTTGAAACagcatatttttttgcatacaggagaaaaaccatacGTCTGTTCAAATTGTGGAAAATCTTTTACACATAAGAAAAGTTTGAAAAGACATATTCTATCACATACCGAAAATCCAAGTTTTTCTTGCCCTCAATGTATGAAACTGTTTTATATATCAGATGATTTAAGAGGCCATATGATCACTCTCTCACAAGCAAGACCATTTACTTGCCCAATTTGTACAAAATCTTTTAAGCAAGTGGGTGACTTAAATAAACATACTTCAATACACTCTAAAGAAAAGCCCCATTCCTGCCCCCAATGTGGAAAGTCTTTTGCCCTTGCGTGCGATTTCAAAAACCATAAGTTAAtccacaataaaataaaaactcattCTTGCCCCAAGCGTGAACAGTTATTTTTAAcagcaaaatatttaaagaggCATATGCGTTCACATTCTGGCATAAAGTATTGTTTGCATTGTGAAAAATCTTATTCGACAAAAGACAATTTAAAGAAGCATAGCCTGATGCACAGCGAAGTGACCTTGATGAATTGTTAA
Protein Sequence: MEDNKIEIVDHEIKKEDDKDYQSNIEIKSEEICIDKIKEENIIPIRHQVCVSDEFKIETEEISSDDVIKEEQRDERVEYCNEKSVIDREKPFTCSLCGKSFKRKGDFKRHSFLHSEIKSPKYKKYICSICGKSLGDKNGMENHMQIHTGEKPFICSFCGKSFRQNADLKQHIFLHTGEKPYVCSNCGKSFTHKKSLKRHILSHTENPSFSCPQCMKLFYISDDLRGHMITLSQARPFTCPICTKSFKQVGDLNKHTSIHSKEKPHSCPQCGKSFALACDFKNHKLIHNKIKTHSCPKREQLFLTAKYLKRHMRSHSGIKYCLHCEKSYSTKDNLKKHSLMHSEVTLMNC

Sequence clustering based on sequence similarity using MMseqs2