Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.004 20 6.0 2.3 29 41 25 37 2 89 0.60

2 5 0.0036 18 6.1 0.0 21 41 86 106 82 112 0.77

3 5 0.0054 26 5.6 0.0 21 41 109 129 105 135 0.77

4 5 0.0059 29 5.5 0.1 21 41 132 152 128 157 0.77

5 5 0.0027 13 6.5 0.1 20 41 154 175 140 188 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.004	20	6.0	2.3	29	41	25	37	2	89	0.60
2	5	0.0036	18	6.1	0.0	21	41	86	106	82	112	0.77
3	5	0.0054	26	5.6	0.0	21	41	109	129	105	135	0.77
4	5	0.0059	29	5.5	0.1	21	41	132	152	128	157	0.77
5	5	0.0027	13	6.5	0.1	20	41	154	175	140	188	0.73

Coding Sequence: ATGTGGAGAGTGGAGATATCGTATCGCAACCCTTGTCGAGAGTGGAAGAGTATGAAGCATCGCACGAGAATGTGGAGAGTGGAGATATCATACAGCAACCCTTGTCGAGAGTGGAAGAGTAAGAAGCATCGCACGAGAATGTGGAGAGTGGGGATATCATATCGCAACCCTTGTCGAGAGTGGAAGAGTATGAAGCATCGCACGAGAATGTGGAGAGTGGAGATATCATACAGCAACCCTTGTCGAGAGTGGAAGAGTATGAAGCATCGCACGAGAATGTGGAGAGTGGAGATATCATACAGCAACCCTTGTCGAGAGTGGAAGAGTATGAAGCATCGCACGAGAATGTGGAGAGTGGAGATATCATATCGCAACCCTTGTCGAGAGTGGAAGAGTATGAAGCATCGCACGAGAATGTGGAGAGTGGAGATATCATATCGCAACCCTTGTCGAGAGTGGAAGAGTATGAAGCATCGCACGAGAATGTGGAGAGTGGAGATATCATATCGCAACCCTTGTCGAGAGTGGAAGAGTATGAAGCATCGCACGAGAATGTTGGAAGTGGCCTGA
Protein Sequence: MWRVEISYRNPCREWKSMKHRTRMWRVEISYSNPCREWKSKKHRTRMWRVGISYRNPCREWKSMKHRTRMWRVEISYSNPCREWKSMKHRTRMWRVEISYSNPCREWKSMKHRTRMWRVEISYRNPCREWKSMKHRTRMWRVEISYRNPCREWKSMKHRTRMWRVEISYRNPCREWKSMKHRTRMLEVA

Sequence clustering based on sequence similarity using MMseqs2