Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 7.7e-39 2.1e-35 122.2 1.0 1 88 12 98 12 98 0.97

2 3 3.3 9e+03 -1.6 0.0 56 78 128 150 125 155 0.74

3 3 9.9 2.7e+04 -3.1 0.1 24 42 295 313 286 320 0.58

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	7.7e-39	2.1e-35	122.2	1.0	1	88	12	98	12	98	0.97
2	3	3.3	9e+03	-1.6	0.0	56	78	128	150	125	155	0.74
3	3	9.9	2.7e+04	-3.1	0.1	24	42	295	313	286	320	0.58

Coding Sequence: ATGCCCCGACCTCTAAAAGAAACATATGGCGATCAAAAGCCACCATTCTCATATATTTCTCTCACGGCCATGGCCATCTGGAGTTCCCCGCAAAAGATGTTGCCTCTGAGCGATATTTACAAGTTTATAATGGATAAATTCCCATATTACCGTAAGAATACACAGAAATGGCAAAATTCGCTGCGCCATAACCTGAGCTTCAACGATTGTTTCATCAAGATCCCAAGGAATACCAACAAAGCTGGCAAAGGCTCCTACTGGACTCTCCATCCAAAGGCATTCGACATGTTTGAAAACGGAAGTCTATTGCGTCGCAGGAAACGCTTCCGCGTACAGAAGCTCGAGAAGGATATGCTTAATGGTGAGCTAGCCGCATTGGCTAGCTTTAACCGATTGTTCATCGctcagcaacagcaacaaagGCAACAACCTCAACCGCAAACTTGGGACTACACACAAATGGCAGTGGCAGGACATCCACACCCGTCGATTTATAGTCAACACCCTCCGATGCACAGCCCTCCGATGTGTATAATGCCAACGTCTCCATCTCCCGAGCTGGACTTGGTGACACCATCCCCCGAGCCACAGCCAATGATGATGTCGATATCAACAGTGCCAGTTACTCGACCGAAACGATCCTTTGATATCGAAAGCCTCATCGCTCCAGACGCAGCGCCCGGCAGCAGCGAAACCCGACTCTGCAAGTCGGAACCAACTGATTTGAGAATATCACCTGCTTTGCCGACGGCTCCAACACCACCAACACCGCCGATGATGGAATCAGCACATCAGCAACCATATCCCATCTATTCCGCCAGCTTTGTCATGCATCCCAGCCCGCCACATCACCTAATGGGTTCATCATCCATGTACAGCCTAGCGGCACACCAGATCCACCCGCTCATGCACCAGCATCATCAGTACCAAATTCAACAACATcaccagcagcaacagcaaGCAGCTGCGGCTGCAGCGGCGGTACTTCTCCATGACCCGCAGGCTGTCTATCGCGGATACCTGGGACCTCTGTCCGTGTTCTAG
Protein Sequence: MPRPLKETYGDQKPPFSYISLTAMAIWSSPQKMLPLSDIYKFIMDKFPYYRKNTQKWQNSLRHNLSFNDCFIKIPRNTNKAGKGSYWTLHPKAFDMFENGSLLRRRKRFRVQKLEKDMLNGELAALASFNRLFIAQQQQQRQQPQPQTWDYTQMAVAGHPHPSIYSQHPPMHSPPMCIMPTSPSPELDLVTPSPEPQPMMMSISTVPVTRPKRSFDIESLIAPDAAPGSSETRLCKSEPTDLRISPALPTAPTPPTPPMMESAHQQPYPIYSASFVMHPSPPHHLMGSSSMYSLAAHQIHPLMHQHHQYQIQQHHQQQQQAAAAAAAVLLHDPQAVYRGYLGPLSVF

Sequence clustering based on sequence similarity using MMseqs2