Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0083 21 6.7 0.4 27 45 66 84 61 91 0.85

2 6 4.3 1.1e+04 -2.0 0.3 24 43 91 110 85 115 0.73

3 6 0.0018 4.7 8.8 0.0 21 45 116 140 108 143 0.87

4 6 1e-05 0.026 16.0 0.0 21 52 144 175 140 175 0.89

5 6 0.017 44 5.7 0.0 21 44 172 195 170 199 0.90

6 6 0.0014 3.6 9.2 0.0 21 48 200 227 195 231 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0083	21	6.7	0.4	27	45	66	84	61	91	0.85
2	6	4.3	1.1e+04	-2.0	0.3	24	43	91	110	85	115	0.73
3	6	0.0018	4.7	8.8	0.0	21	45	116	140	108	143	0.87
4	6	1e-05	0.026	16.0	0.0	21	52	144	175	140	175	0.89
5	6	0.017	44	5.7	0.0	21	44	172	195	170	199	0.90
6	6	0.0014	3.6	9.2	0.0	21	48	200	227	195	231	0.86

Coding Sequence: ATGGAGATCAAACAAGAAAGCGAAATGCACAATTATGAATTcataaaagtaaaagaagaagcTCCAGAGCTTTCCGAAGAAtcggaattttttaaatcagaacCAAAAGACTGTacgataataaaaaaagaaaatgacgaAAATTCATCATCCGATCAGATAACTTATTGTGGCTTAGTTCCAAAAATATTCCGTTGCGATCAGTGCCCGGAAATATTTCGACAATCGATTCTCTTACGTAAACATCTACGAAAACATATCAAACGAGGACCATATCCATGCACAGTGTGTCACAGAGAATTTACGAGACGCAGTTATCTACGCGAACATACAAGATGTCACACCGGTGAAAAACCTTACCAATGCGATATATGTTTGACATCATTTTCACAAGCGGGCAATTTGAATGTTCACATGAAGACGCacaccggtgaaaaaccattccAATGTGACGTATGTTTAATACCATTTTCACAGGCGGGAAATTTACGACGTCACATGAAATTACATACGGGCGAAAAACCGTACAGTTGTACAGTGTGTGAAAAGAGATTTTCCGAGGCGTTTAATTTACGAAAACACGAGAAAGTACATACACGTGAAAAACCGTTCAATTGTACAGTGTGTGCGAAAAGTTTTTCCGAATCGTCGAACTTAAAGAAACATATGATAATTCATACGGGTGCAAAACGATATCAGTGCAGTCTATGTCCGAAAAAATTTACTCAATTGTCACATTTAAAGGTGCATAGAAGGTGTCATGCgcgaaaaaagacaaaatcgtGA
Protein Sequence: MEIKQESEMHNYEFIKVKEEAPELSEESEFFKSEPKDCTIIKKENDENSSSDQITYCGLVPKIFRCDQCPEIFRQSILLRKHLRKHIKRGPYPCTVCHREFTRRSYLREHTRCHTGEKPYQCDICLTSFSQAGNLNVHMKTHTGEKPFQCDVCLIPFSQAGNLRRHMKLHTGEKPYSCTVCEKRFSEAFNLRKHEKVHTREKPFNCTVCAKSFSESSNLKKHMIIHTGAKRYQCSLCPKKFTQLSHLKVHRRCHARKKTKS

Sequence clustering based on sequence similarity using MMseqs2