Basic Information

Insect: Bombyx mori
Gene Symbol: foxc2
Assembly: GCA_027497135.1
Location: CP114969.1:13349851-13350858[-]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.5e-43 2.7e-40 136.4 0.1 2 87 57 141 56 142 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.5e-43	2.7e-40	136.4	0.1	2	87	57	141	56	142	0.97

Sequence Information

Coding Sequence: ATGCATGCTCTTTTCGGTGAACAAAGCCCATATGCGTACCGCGGTGGTGCGGCCGGTGGATATTCAGCCGGCGTCGCACCATACGCTTATGAACAATATCGCTATGGTTATGGAGCCCCGTACCTCCACCCGCATCAGCAGCATGTGGGGGCACCGAAAGACATGGTCAAACCGCCATACTCGTACATAGCCCTTATTGCGATGGCAATACAGAATGCACCAGAGCGGCGCATCACGTTGAATGGTATTTATCAGTTTATCATGGAGCGATTTCCCTATTATAGAGAAAACAAACAAGGATGGCAAAATTCTATAAGACACAACTTAAGCCTCAACGAGTGTTTTGTTAAAGTAGCCAGAGACGATAAAAAACCTGGTAAAGGTAGTTATTGGACATTAGACCCAGATTCGTATAACATGTTCGATAACGGTTCATATCTAAGGCGGCGGCGCCGTTTCAAGAAAAAAGATGCTTTAAAGGAAAAAGAAGAAGCACTTAAGCGACAACAGCAACTTCAACAAGCACAGGAGGCGCTCGCCGCACAAGAAGCGTTATCGGCAGCTGATGCTCTCGGACAGCAACGTGACGTCAAACCTGATGTAAAACCACGGATTTTTGAGTGCCGACCGAAGAGGGAACCCGGCGCAGAATGCACAAGATACGATAAGCCAGTAGATTCGATTGACGAATTCAATGAACCGAGATTGCCGCCGTCTGCGGTGTACTGTTCTCCGCAGCCGTATTCTTTAGCGGCAGAAGATTTTCGTGCAGCCACATCGGGATGGTATACAGCACCCGAGCCTCCGGCCGAGCAACTCCCGCCGGCTTTTCGTGATTTATTTGAACCACCAAGCTGTCAGTTGGCTGGGTTTCGGGGAGGCTCGCCACCGCCGGAAGCTTACCGCGCGTCGCCGCCGCATCACCACTATCGCACGCCGGCGCCGTCTTACTACCACCACCAGGCGTGTGTGGCTGCTGCACCCGCTCCGGCACACAAGTCCTATTGA
Protein Sequence: MHALFGEQSPYAYRGGAAGGYSAGVAPYAYEQYRYGYGAPYLHPHQQHVGAPKDMVKPPYSYIALIAMAIQNAPERRITLNGIYQFIMERFPYYRENKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSYLRRRRRFKKKDALKEKEEALKRQQQLQQAQEALAAQEALSAADALGQQRDVKPDVKPRIFECRPKREPGAECTRYDKPVDSIDEFNEPRLPPSAVYCSPQPYSLAAEDFRAATSGWYTAPEPPAEQLPPAFRDLFEPPSCQLAGFRGGSPPPEAYRASPPHHHYRTPAPSYYHHQACVAAAPAPAHKSY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00072528;
90% Identity: iTF_00787425; iTF_00428805; iTF_00290470; iTF_00390183; iTF_00818954; iTF_01429739; iTF_00640084; iTF_00819861; iTF_00427900; iTF_00235677; iTF_00419588; iTF_00421154; iTF_00382373; iTF_00447970; iTF_00076257; iTF_00925537; iTF_01148641; iTF_01129860; iTF_01495588; iTF_00278917; iTF_00006887; iTF_01140039; iTF_01145864; iTF_01415625; iTF_00074282; iTF_00432938; iTF_00284331; iTF_01140747; iTF_01147915; iTF_01494124; iTF_01081389; iTF_01142927; iTF_01496367; iTF_01494866; iTF_01141459; iTF_01145107; iTF_00035445; iTF_00761429; iTF_01436821; iTF_00026649; iTF_01090492; iTF_01083102; iTF_01115518; iTF_00075263; iTF_00431935; iTF_01416575; iTF_01251552; iTF_00637281; iTF_01359521; iTF_00970211; iTF_01207914; iTF_01209008; iTF_00673297; iTF_00025080; iTF_00971037; iTF_01561825; iTF_01205508; iTF_01204677; iTF_01385511; iTF_01203050; iTF_01388271; iTF_01340953; iTF_01387419; iTF_01386525; iTF_00374978; iTF_00907681; iTF_00318690; iTF_00038499; iTF_00120292; iTF_01285348; iTF_01526820; iTF_00809861; iTF_01092869; iTF_01246629; iTF_01534597; iTF_00273414; iTF_00784198; iTF_01525734; iTF_00124039; iTF_00446919; iTF_00726087; iTF_00913415; iTF_01361383; iTF_01029960; iTF_00036425; iTF_00924393; iTF_00037578; iTF_00274250; iTF_00808906; iTF_01119082; iTF_01192426; iTF_01230314; iTF_00039595; iTF_00300971; iTF_00951595; iTF_01084939; iTF_01118059; iTF_01312043; iTF_00111404; iTF_00785004; iTF_00041581; iTF_00077293; iTF_00906861; iTF_00928461; iTF_01116973; iTF_00122158; iTF_00176910; iTF_00301902; iTF_01094702; iTF_00121199; iTF_00444911; iTF_00299952; iTF_00373712; iTF_00810800; iTF_01093840; iTF_01339760; iTF_00123153; iTF_00685233; iTF_01221297; iTF_01424849; iTF_01439697; iTF_00888018; iTF_01338290; iTF_00973523; iTF_01061683; iTF_00040596; iTF_01064436; iTF_01084052; iTF_00043285; iTF_00172533; iTF_00237269; iTF_00363829; iTF_00622613; iTF_00745429; iTF_01025781; iTF_00185942; iTF_00448822; iTF_00757942; iTF_01440790; iTF_01531766; iTF_00667159; iTF_01030935; iTF_01362295; iTF_01435863; iTF_00425176; iTF_00445912; iTF_00830968; iTF_00905915; iTF_01317083; iTF_00850396; iTF_01029020; iTF_01062556; iTF_00771677; iTF_00783229; iTF_00147102; iTF_01027102; iTF_01532830; iTF_00383423; iTF_01063551; iTF_00711616; iTF_00851520; iTF_01028064; iTF_00822690; iTF_00441287; iTF_00823729; iTF_01197525; iTF_01099682; iTF_01501890; iTF_00186947; iTF_00888995; iTF_01403247; iTF_00006096; iTF_01377273; iTF_00017146; iTF_00017981; iTF_00723773; iTF_00449924; iTF_00049702; iTF_00709992; iTF_00171562; iTF_00710839; iTF_00280934; iTF_00794123; iTF_00282071; iTF_01166398; iTF_00957766; iTF_01342022; iTF_00204935; iTF_00194984; iTF_00408200; iTF_00772680; iTF_00148289; iTF_00409091; iTF_00659267; iTF_00410084; iTF_00412325; iTF_00680326; iTF_00662889; iTF_00660113; iTF_00656946; iTF_00658162; iTF_00289429; iTF_00411223; iTF_00654039; iTF_01133527; iTF_00655897; iTF_00149180; iTF_01072252; iTF_00871101; iTF_00462176; iTF_00407369; iTF_00157004; iTF_00406514; iTF_00736425; iTF_01193417; iTF_01425770; iTF_01172134; iTF_00636075; iTF_00953323; iTF_00954214; iTF_00275052; iTF_01500908; iTF_01302093; iTF_00364718; iTF_00011745; iTF_00012738; iTF_00832707; iTF_00960739; iTF_00007812; iTF_01503652; iTF_01154821; iTF_01182474; iTF_00354892; iTF_01569068; iTF_00027565; iTF_00249520; iTF_00922704; iTF_01176016; iTF_01402545; iTF_00207667; iTF_01071444; iTF_00751830; iTF_01158518; iTF_01502775; iTF_01156090; iTF_01153659; iTF_00197180; iTF_00180253; iTF_01020029; iTF_00840126; iTF_01157471; iTF_01538542; iTF_00858351; iTF_01358693; iTF_00341141; iTF_00063383; iTF_01010171; iTF_00859264; iTF_00072528; iTF_01220458; iTF_00720011; iTF_00150288; iTF_00404496; iTF_00908616; iTF_00204177; iTF_00818163; iTF_00821580; iTF_00358324; iTF_00357226; iTF_01143668; iTF_00072053; iTF_00942613; iTF_01082241; iTF_01336630; iTF_00000119; iTF_00114743; iTF_01491681; iTF_00287864; iTF_01151865; iTF_00869425; iTF_00000986; iTF_00177882; iTF_00347322; iTF_01125249; iTF_00744410; iTF_01178209; iTF_00255620; iTF_00687716; iTF_00405734; iTF_00786572; iTF_00934541; iTF_00256655; iTF_00144371; iTF_00403571; iTF_01217299; iTF_01247892; iTF_00288663; iTF_00250264; iTF_00647801; iTF_00933529; iTF_01489945; iTF_00770909; iTF_00164127; iTF_00844122; iTF_00681467; iTF_00683129; iTF_01332347; iTF_01202277; iTF_00326888; iTF_01203848; iTF_01337578; iTF_00878673; iTF_01206359; iTF_00185113; iTF_00706748; iTF_01360412; iTF_00682173; iTF_00467263; iTF_00467997; iTF_00621824; iTF_01173076; iTF_01073408; iTF_01334560; iTF_01529000; iTF_00266988; iTF_01528083; iTF_01335733; iTF_00662038; iTF_00661083; iTF_01180129; iTF_00376906; iTF_01179306; iTF_01443635; iTF_00638455; iTF_01219588; iTF_00632565; iTF_01428855; iTF_00737276; iTF_01076190; iTF_01264202; iTF_00677344; iTF_00796329; iTF_00985799; iTF_00896577; iTF_01034337; iTF_00621028; iTF_00778596; iTF_00055205; iTF_00649829; iTF_00959973; iTF_00212230; iTF_00247846; iTF_00776582; iTF_00780070; iTF_00213223; iTF_00843305; iTF_01564361; iTF_01077994; iTF_01437771; iTF_00246988; iTF_00774316; iTF_00780844; iTF_01181709; iTF_01438701; iTF_00782446; iTF_00958510; iTF_00461360; iTF_00159633; iTF_00648913; iTF_00695281; iTF_00959217; iTF_00775858; iTF_00777810; iTF_01079698; iTF_00795507; iTF_00345620; iTF_00842453; iTF_01033525; iTF_01080535; iTF_00947704; iTF_00457818; iTF_00457051; iTF_00777243; iTF_00779323; iTF_01506971; iTF_00722844; iTF_00775069; iTF_00781629; iTF_00824510; iTF_01507870; iTF_00166751; iTF_01078879; iTF_00984832; iTF_01506144; iTF_00967851; iTF_01135557; iTF_01245739; iTF_00155116; iTF_00325173; iTF_01463061; iTF_00156058; iTF_01134588; iTF_00342016; iTF_00009809; iTF_01463965; iTF_00008704; iTF_00931026; iTF_00932221; iTF_00708980; iTF_00856406; iTF_00836323; iTF_00835352; iTF_00837272; iTF_00834431; iTF_00361416; iTF_01075176; iTF_00119412; iTF_00686141; iTF_00317918; iTF_00418775; iTF_01279991; iTF_01020993; iTF_00642148; iTF_01017543; iTF_00352843; iTF_01018383; iTF_01151029; iTF_00353882; iTF_01282027; iTF_01281111; iTF_01279069; iTF_00208635; iTF_00674114; iTF_01401085; iTF_00806496; iTF_00355931; iTF_00112317; iTF_00113934; iTF_00113141; iTF_00790045; iTF_00420350; iTF_01333534; iTF_01331233; iTF_00323295;
80% Identity: iTF_00235677;