Basic Information

Gene Symbol
prg
Assembly
GCA_003987935.1
Location
NW:423172-426390[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.22 9.9 6.4 1.6 2 23 180 202 179 202 0.85
2 10 0.044 2 8.6 2.2 1 23 208 231 208 231 0.96
3 10 5.7e-06 0.00026 20.8 4.1 1 23 237 259 237 259 0.96
4 10 1.1e-06 5e-05 23.0 3.0 1 23 265 287 265 287 0.99
5 10 1.4e-05 0.00066 19.5 0.1 1 23 293 315 293 315 0.97
6 10 0.00091 0.041 13.9 1.4 1 23 321 343 321 343 0.97
7 10 0.00022 0.01 15.8 3.4 2 23 438 460 437 460 0.95
8 10 0.00024 0.011 15.7 1.5 1 19 466 484 466 488 0.94
9 10 0.0015 0.069 13.2 2.7 3 21 496 514 494 515 0.92
10 10 0.0011 0.051 13.6 0.0 3 23 525 545 523 545 0.92

Sequence Information

Coding Sequence
ATGAAAATGGAAGATTCCTTTATTATAGCCAATTTTAATTCTCTGTGTCGCCTTTGCCTCGGTAAAAGTAGACTCGCCATCTCAATATTCGGAGCTGCACCTGATGACATTAATAACGTATCATTGACCTCCAAAATAGCTGAATGTTTTGAGTTACAGATCGATCCTAATGATGGTTTACCTGGCAGGATTTGTTACAAGTGCTTATTCAAAGTGGACAAgtgttcaaaattcaaattacaatGTATCCAAAGTGAAAACAGACTCAGACAAATCACAAATCGTATAAATGAAGTAGATACTTCAAACTCATctgaaattactaattacacATACAGCAATTCCCAAGATGAACAGAAACATAAGCCTGAAGATTTTATTGTTGAAGATAGCGTTGTGATGGTGGTTGATCCTAGTCTTGATTATGATTCTTCGGATGATTCTGAAAATGTAGAAACTGTGGAGCAAGAAAATACTGATCGAGGCAATACTCCTGATGCGGATGCAATTCCGGAAACATTTTTCAAGAATGTTTCAATGTGCCAATATTGTGATCAAGCTTTCATTTCACAAGAAAAATGTAAAGAGCATGAACTAAACTATCATGATCCAGACATGCCTTTTAAATGTTATGAATGCAGTTTGGCTTTTGTGGAAAGAAATCAGTATGTACAGCATACGAAACATGTCCATGGAAATGACAAGCCCTATCATTGCCCTGAATGTAATAAATGTTTTGGACGAAGATCTGATCTAAGAAAACATTCTATTGTACATACAGGTATCAGACCTTACCAGTGTCAATTTTGCTTGAAGAGTTTTTCACGTAACACAAACTTGAGCAAACACTTGAGAATACACGCTGGTCACAGACCTCATGTTTGCCCTCTGTGCCCTCGTAGCTTTGTAGCCAAAGGTGACCTACAACGACATGTTCTTGTTCATTCTGGCATGAAGCCTTATTCGTGCAGAAAATGTCCCTCTACATTTGGACGAAGAGATAAGCTCATTAAACATGAACTAAAACATGGAATTGTTGCCACTGAGGATAAACCTGAAGACTATGCCAACAGTGTTAAACAGGATCCAAATGACATTGTTGTCAGTGTCAATCCTTTCAGTAACCTCATGACTTCTCCAACACAAAATTCAGATCCTTCAAACCCTACTTACGAACTTCCTAGTGTTCCTGACCATATTTCTGGGGAAAGTAGTTTTATAAAGATGCAAAAAGATCCCTCCACATCACATAAACAACAAAACTCATCACCAAAAAAGGCTACACCAGTTAAGAACAGAccaaaaaacataaaatgcCATCACTGcacaaaaaagttttcttccctaGATGCATACAAAACTCATGTTTCAATTGCTCATATGGGATCAAGAGGATTTCaatgtaaaatatgttttaagaaattttccaaaaaaaggGAGTTAGATCGACATGCTCCAATTCACACTGGAGGTAAACAATTAGCTTGTGACCACTGTGATAAAAAGTTTACTAAAAAAGACAAATTTGATAAACACAAACAGTCACAGGAATGTTTGGTTGTGAATATGCCTTGTATAGAGTGTGGTGTTACCTTTGAAAAGAAAGCTGACTTGGTTGCACATATTAAATCACACTTCAATGATACCTATGATAAGTTACAGATTCCAGATGTTGAGATTAAAGTAGAGAAAGATCCAGAAATACCATGTGATGAAAACTATTATGATTTGGGAACATGA
Protein Sequence
MKMEDSFIIANFNSLCRLCLGKSRLAISIFGAAPDDINNVSLTSKIAECFELQIDPNDGLPGRICYKCLFKVDKCSKFKLQCIQSENRLRQITNRINEVDTSNSSEITNYTYSNSQDEQKHKPEDFIVEDSVVMVVDPSLDYDSSDDSENVETVEQENTDRGNTPDADAIPETFFKNVSMCQYCDQAFISQEKCKEHELNYHDPDMPFKCYECSLAFVERNQYVQHTKHVHGNDKPYHCPECNKCFGRRSDLRKHSIVHTGIRPYQCQFCLKSFSRNTNLSKHLRIHAGHRPHVCPLCPRSFVAKGDLQRHVLVHSGMKPYSCRKCPSTFGRRDKLIKHELKHGIVATEDKPEDYANSVKQDPNDIVVSVNPFSNLMTSPTQNSDPSNPTYELPSVPDHISGESSFIKMQKDPSTSHKQQNSSPKKATPVKNRPKNIKCHHCTKKFSSLDAYKTHVSIAHMGSRGFQCKICFKKFSKKRELDRHAPIHTGGKQLACDHCDKKFTKKDKFDKHKQSQECLVVNMPCIECGVTFEKKADLVAHIKSHFNDTYDKLQIPDVEIKVEKDPEIPCDENYYDLGT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01490377;
90% Identity
iTF_00236874;
80% Identity
iTF_00236874;