Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_014825825.1
Location
CM026109.1:5680238-5690749[-]

Transcription Factor Domain

TF Family
THAP
Domain
THAP domain
PFAM
PF05485
TF Group
Zinc-Coordinating Group
Description
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 3.1e-16 5.4e-13 49.6 0.2 1 87 25 104 25 104 0.86
2 3 0.47 8.1e+02 0.9 0.3 24 64 399 438 382 452 0.58
3 3 6 1e+04 -2.6 0.9 52 85 1050 1078 1026 1090 0.48

Sequence Information

Coding Sequence
ATGAAGCGACGACGTGTAGCGTCGCATATTAAAAAGATATCGCTTGTGAGAACAATGAGAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAGGCTGATGTGCAAGATGCACGTACTAAAGGGTTACCGCTTCATAAATTTCCAAAAGATATTAATTTAAGGAACAAATGGTTGACTAGTGGTGGATTCGAAGCGAGCTTTAAACCTTCACCAGGTCAGGTTGTTTGTCATAGACACTTCAAACGAGCCGACTACGAAGCTGCTAAAGGACATAAATTACTTCTACGTAAGGGCAGCGTTCCGTCGGTTTTTGAGGACTATGACAATCATCCAGATCCTGTAATTATGTCTGTAAAATCATCAACTTCTTATGCACAGGAAGATTTAGATCTTATTAATTCTGAAATTCTGAACTTAGAACAATCTACCTTTTCATTGAATTCTGGACTCAGAGCATTAAAGTCTAATAATTGTGGAGAAACATGTTCTTCTCGACCAGAACCATCAGTTAATTCCTTCAATTTACTAGATTCAACAGAATTACTTGATAATGGATGTAAGAACTTTAATGTGAAAGAAGAAAATGTATATACTGTGAAACAAGAGATAAATAAAAATTCAGAAATAGAAGTGAATACTATGGCAGTGCAATTAGGCATTGTTGAATCTGATATAGCAATAAAACATATACAAAAAGATTTGGCCATTAAGGAAGAACTGAAAAGTATGGAAGTGGAAGATGAAAAAACATTTGATAAACCAGAAGAATTAAAACCAAAAATTTTTAATCGTGGTGGACTAAAATTTTTTCCTGGTGCCAAATTGGAAGCGAAAGATTTCAATGAAAAATGGTATTCAGCGAAAGTAGTTGAAACTGATTGGGATGAACGAGAAGTATTGATACGTTTTGACAAGTGGAGTTCAAGGTTTGATGAATGGATACCTATGGATAGTTCAAGATTACGTGTATTGCAAACACAATCAAACGAACAAACCTGGAATCTACCATCTCAGGAAACAAAAATGAAAGACTTTTCAATGGGAGAAAGGATACTTGCTACGTGGGCTGATGGTAGAAAATATCCAGCTAAAGTAAATGCCGTCTTAGGAAACGATAGATATGATGTACTGTTTGATGATGGATATACAAAGACAATTAAATCGTCAAAAATGACAAAAATTGCTACAACAGTCACAAAGCAACCTAGTCAAACTGAAGAATATATAGGAAGCAAGCAAGAAAGAAGAGATAAGAAAAGAAAGCATACAGTGATGGAGTTATTTCATACACATTATAGAAAACGTTCAAAAAATGAAACAGATAAATTAATAAAAAAGGAAGGAATTATAGTTAATGAAAATGTAGAATGCTTTTCGGAAAATAAAATTGATTTAGATGGAACTTTATTTGGGCCCTGCTATGATCCAGGGACAGATTTATTACGTGGGTTTGACACCAATGTATCTAAAATGAAAGCTTATCCTAAAAAAAGTAAAAAGGAAGTATCTAAGAATGAAATAGATCAAGTAGAAGATGTGGGTCCTGAATGGATTGATGGAGAACCTCAGGGAACTGAATCTTATATAGTGGATGGAAATGATGGACCACGTCGATCAATAATAGTTGCAGACAGAAGATTACCACCTGGATGGCAAAAACATTTTACTCAAAGAAAAGCTGGTACATCAGCTGGAAAGTGGGATGTCTTATTTCTTCATAAATCAAGTGGGAAAAAATTTAGATCAAAAAATGATATTAGGACATTTATGGAAAATCAGGGGCAATTCGACTTTGATCCAGAAAAATTTGATTTTTGCATTCATCGAAAAAAGAAAAATCAAAGTCAAAAAGTAAAACAAGATATCGTTGTGGATACTCCAAAAAAGATTAAGACTTTATTGCCTAAAACAAAGGCAACACCAGTAACTGAGAATTCTTTACCTGTTCCCCCAAGTACACCAGTTACAACATTATTATCTACATCAAGTACATCTATTAAAGATGGTGCTGTTTTTATTGGTGGACTTCGAGTAGAAATGGAGGACAGTGCTTATAAATGTCCGAAACAAGGGTGTAGTAAAACATTTAGGAAGGAAAATCTTCTACAAATGCATATAAAACATTATCATCCAGAATATTCGAAATTTTTGGGATCTACACCAAATGTTGCAGATTTAGCTTATGCAAGAACAATTGGGGAATCTGTTGAAGATATTATTCCAAAAAAGTCAAATAATTTGTTAGAAAAGTGCAATAAATTTGGAAAGAGAAAATTTATTCAAGATAAATCATTGTATGTTTCATCATCTTCTGTAACAAGCACTCTTCAACCTATATCGCCAACAGCAATTGTACCAACAACAGTAGAAACAGAGGATGAAGTAGACCAAATGGAAAAATCCAATGATGTGCAAACAGACGATATTAAAATGGATAGAATGTCTCCAAGTTCTAGTCATAGTTTAGATATGGATGACGAAGTAGAACAAAAACAGGAAGATACATGTGCAATGTCACCAGGAACACTATTTGATATGAAAATTAGGGAAGAAAAAACACAAAGTGGCATTAAGACACTTCTTCCGGTAAGACCAGCCATGTCTTCAGAAGCACAACGAATTGATAGATCAAAGTCTTTAGATGAAGCTATTCATATCGACAAAATTAAAGGTCAAAGGAAACGACAATTATCAGAATATAGTTCTGATGCATTAAACAGAAGTAAAAGGCGACATGAATTTCCGGACGAGTATGGTGATTTAGATGATAGTACTATGGATATAGAAGGAGGAGGACCGACTACACCCACGTATAGATATAGTCGCAGAAAATCAGATTCAAGAAGTGATGAAAATAGCCAAAGTAGTCAACTAACCGATTCGCGTGTTGAGAAAGATGATCCCTTGAAAGGGAATATTGGTAAAAAAGATACTAATGATGGGGAAGAGAATGAAGGAGTTATGATGATGATCAATGGTGAAATGGTGAAAGTGGAGCAGCTTCGTAGAGAAGAAATAATAAATTGCACTTGTGGATTTATGGAAGAAGATGGTTTAATGATTCAATGCGACCTTTGTTTGTGTTGGCAACATGGTCACTGCAATGCAATAGAAAAGGAAAAGGATGTACCTGAGAAATATGTTTGTTTTATTTGTCGGAATCCATATCGGCAACGATTATCCAAAAAATATTTTCACGATCAAGATTGGATAAAAGAGGGAAAGCTACCAACATTATCTAGCCGAACAAAAAATCAGCATCGAGTTAATCAAAGAACAGCTATGTTAAAACGTTCTTATGATCTAGTTGCTGCTCTTTTACACATTCAGCAAGTTTTACATAGTTTAAGAGTAAAAATCAATGTAGCTCAAAAGAAAGATCATCCAAAGCTATATCTGTGGGCCAAAAATTGGGAAAAAGTTGAAGTACCAAAACCAAATGTCACGCCAGTACCAATCATGGAGATTATGAAAGTAGGAAAAGAGTGTACAGATATTCCAAATGAAAGTTTTCATCGAACTGAAGTAAAAACGGAAACAAAGTTCAGTTTAAGAGATGATCATGATGAAAAGTCGATAGCCTCAGATTCAGAATTAATGAAGATATTAGAAGAAGATAATATAACTCCAGATGAATCTAAAATTAACGGCAAAAAGGAAGATATACATCAAACTAAAAGTCATATTCTTCTCGATGCACTTACGAAAAACGATACTTCAGAAGGAAAATATACAAATTCATTACCTTCAGAGGTGAAAACAGATACAGATTTGTTAACCAATCAATCAGATATATACGAGAATAACGTATCTCCGACAACTATATCAGCGAATCACATGCATGAAGAACTAAATGAACATGAAATGTCAGCACCGTTGCAACCTTTCATACCACAACCAGAAGCGCCAATTGACCCAGGAGAATGTCGAATGCGATTATTAGAACACATAGAACATTTTCAACATCATATAGATGCAAAATTAACATTCATCGAGGCAGAAGTTTGTGATACATCTACCTTAGATGTTCAGCCTCGCACTAAACAAACGATTCAAATGCTTGTTCGAGATTTAAACACTGTGCGAAAATTAGCTGCTTTGTGTTGA
Protein Sequence
MKRRRVASHIKKISLVRTMRMARKCCVRSCEADVQDARTKGLPLHKFPKDINLRNKWLTSGGFEASFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSVPSVFEDYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSTFSLNSGLRALKSNNCGETCSSRPEPSVNSFNLLDSTELLDNGCKNFNVKEENVYTVKQEINKNSEIEVNTMAVQLGIVESDIAIKHIQKDLAIKEELKSMEVEDEKTFDKPEELKPKIFNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIRFDKWSSRFDEWIPMDSSRLRVLQTQSNEQTWNLPSQETKMKDFSMGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYTKTIKSSKMTKIATTVTKQPSQTEEYIGSKQERRDKKRKHTVMELFHTHYRKRSKNETDKLIKKEGIIVNENVECFSENKIDLDGTLFGPCYDPGTDLLRGFDTNVSKMKAYPKKSKKEVSKNEIDQVEDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADRRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSKNDIRTFMENQGQFDFDPEKFDFCIHRKKKNQSQKVKQDIVVDTPKKIKTLLPKTKATPVTENSLPVPPSTPVTTLLSTSSTSIKDGAVFIGGLRVEMEDSAYKCPKQGCSKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSNNLLEKCNKFGKRKFIQDKSLYVSSSSVTSTLQPISPTAIVPTTVETEDEVDQMEKSNDVQTDDIKMDRMSPSSSHSLDMDDEVEQKQEDTCAMSPGTLFDMKIREEKTQSGIKTLLPVRPAMSSEAQRIDRSKSLDEAIHIDKIKGQRKRQLSEYSSDALNRSKRRHEFPDEYGDLDDSTMDIEGGGPTTPTYRYSRRKSDSRSDENSQSSQLTDSRVEKDDPLKGNIGKKDTNDGEENEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYVCFICRNPYRQRLSKKYFHDQDWIKEGKLPTLSSRTKNQHRVNQRTAMLKRSYDLVAALLHIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKVEVPKPNVTPVPIMEIMKVGKECTDIPNESFHRTEVKTETKFSLRDDHDEKSIASDSELMKILEEDNITPDESKINGKKEDIHQTKSHILLDALTKNDTSEGKYTNSLPSEVKTDTDLLTNQSDIYENNVSPTTISANHMHEELNEHEMSAPLQPFIPQPEAPIDPGECRMRLLEHIEHFQHHIDAKLTFIEAEVCDTSTLDVQPRTKQTIQMLVRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01539602;
90% Identity
iTF_00216442;
80% Identity
iTF_00231318;