Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_014737365.1
Location
JACXIL010000278.1:312724-317251[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.66 3.1e+03 -2.1 0.1 44 68 45 69 42 72 0.91
2 2 2.1e-17 1e-13 50.8 0.2 6 69 152 215 147 223 0.90

Sequence Information

Coding Sequence
ATGACAAAAATCGCTACAACAGTCACAAAGCAACCTAGTCAAACTGAAGAATATATAGGAAGCAAGCAAGAAAGAAGAGATAAGAAAAGAAAGCATACAGTGATGGAGTTATTTCATACACATTATAGAAAACGTTCAAAGAATGAAACAGATAAATTAATAAAAAAGGAAGGAATTATAGTTAATGAAAATGTAGAATGCTTTTCAGAAAATAAAATTGATTTAGATGGAACTTTATTTGGGCCTTGCTATGATCCAGGCACAGATTTATTACGTGGGTTTGACACCAACATATCTAAAATGAAAGCTTATCCTAAAAAAAGTAAAAAGGAAGTATCTAAGAATGAAATAGATCAAGTAGAAGATGTGGGTCCTGAATGGATTGATGGAGAACCTCAGGGAACTGAATCTTATATAGTGGATGGAAATGATGGACCACGTCGATCAATAATAGTTGCAGACAGAAGATTACCACCTGGATGGCAAAAACATTTTACTCAAAGAAAAGCTGGTACATCAGCTGGAAAATGGGATGTCTTATTTCTTCATAAATCAAGTGGGAAAAAATTTAGATCAAAAAATGATATTAGGGCATTTATGGAAAATCAGGGGCAATTCGACTTTGATCCAGAAAAATTTGATTTTTGCATTCATCGAAAAAAGAAAAATCAAAGTCAAAAAGTAAAACAAGATATCGTTGTGGATACACCAAAAAAGATTAAGACTTTATTGCCTAAAACAAAGGCAACACCAATAACTGAGAATTCTTTACCTGTTCCCCCAAGTACACCAGTTACAACATTATTATCTACATCAAGTACATCTATTAAAGATGGTGCTGTTTTTATTGGTGGACTTCGAGTAGAAATGGAGGACAGTGCTTATAAATGTCCGAAACAAGGGTGTAGTAAAACATTTAGGAAGGAAAATCTTTTACAAATGCATATAAAACATTATCATCCAGAATATTCGAAATTTTTGGGATCTACACCAAATGTTGCAGATTTAGCTTATGCAAGAACAATTGGGGAATCTGTTGAAGATATTATTCCAAAAAAGTCAAATAATTTGTTAGAAAAGTGCAATAAATTTGGAAAGAGGAAATTTATTCAAGATAAATCATTGTATGTTTCATCATCTTCTGTAACAAGCACTCTTCAACCTATATCGCCAACAGCAATTGTACCAACAACAGTAGAAACAGAGGATGAAGTAGACCAAATGGAAAAATCCAATGATGTGCAAACAGACGATATTAAAATGGATAGAATGTCTCCAAGTTCTAGTCATAGTTTAGATGTAGATGATGAAATTGAACAAAAACAAGAAGATACGTGTGCAATGTCGCCTGGAACACTATTTGATATGAAAATTAGGGAAGAAAAAACGCAAAGTGGCATTAAAACACTTCTTCCGGTAAGACCAGCCATGTCTTCAGAAGCACAGCGAATTGATAGATCAAAGTCTTTAGATGAAGCTATTCATATTGACAAAATAAAAGGTCAAAGGAAACGACAATTATCAGAATATACTTCTGATGCATTAAACAGAAATAAAAAGCGACATGAATTTCCGGACGAGTATGGTGATTTAGATGATAGTACTATGGATATAGAAGGAGCAGGACCGACTACACCCACGTATAGATATAGTCGCAGAAAATCAGATTCAAGAAGTGATGAAAATAGTCAAAGTAGTCAACTAAACGATTTGCGTGTTGAAAAAGATGATCCCTTGAAAGGGAATATTGGTAAAAAAGATACTAATGATGGGGAAGAGAATGAAGGAGTTATGATGATGATCAATGGTGAAATGGTGAAAGTGGAGCAGCTTCGTAGAGAAGAAATAATAAATTGCACTTGTGGATTTATGGAAGAAGATGGTTTAATGATTCAATGCGACCTGTGTTTGTGTTGGCAACATGGTCACTGCAATGCAATAGAAAAAGAAAAGGATGTACCTGAGAAATATGTTTGTTTTATTTGTCGGAATCCATATCGGCAACGTTTATCCAAAAAATATTTTCACGATCAAGATTGGATAAAAGAGGGAAAGCTACCAACATTATCTAGTCGAACAAAAAATGAGCATCGGTTTAATCAAAGAACAGCTATGTTAAAACGTTCCTATGATCTAGTTGCTGCTCTTTTACACATTCAGCAAGTTTTACATAGTTTAAGAGTAAAAATCAATGTAGCTCAAAAGAAAGATCATCCAAAGCTATATCTGTGGGCCAAAAATTGGGAAAAAGTTGAAGTACCAAAACCAAATGTGACACCAGTACCAATCATGGAGATTATGAAAGTAGGAAAAGAGTGTACAGATATTCCAAGTGAAGGTTTTCAACGAACTGAAGTAAAAACGGAAACAAAATTCAGTTTAAGAGATGATCATGATGAAAAGTCGATAGCTTCAGATTCAGAATTAATGAAGATATTAGAAGAAGATAACATAACTCCAGATGAATCTAAAATTAACGGCAAAAAGGAAGATATACATCAAACTAAAAGTCATATTCTTCTCGATGCACTTACGAAAAATGATACTTCAGAAGGAAAATATACAAACTCATTACCTTCAGAAGTGAAAACAGATACAGATTTGTTAACCAATCAGTCAGATATATACGAAAATAACGTATCTCCGACAACTATATCAGCGAATCACATGCATGAAGAACTAAATGAACATGAAATGTCAGCACCGTTGCAACCTTTCATACCACAACCAGAAGCGCCAATTGACCCAGGAGAATGTCGAATGCGATTATTAGAACACATAGAACATTTTCAACATCATATAGATGCAAAATTAACATTTATTGAGGCAGAAGTTTGTGCTTTAGAAGCCATGGATCCTGAAGATACATCTACCTTAGATGTTCAACCTCGAACTAAACAAACGGTTCAAATGCTTGTTCGAGATTTAAACACCGTGCGAAAATTAGCTGCTTTGTGTTGA
Protein Sequence
MTKIATTVTKQPSQTEEYIGSKQERRDKKRKHTVMELFHTHYRKRSKNETDKLIKKEGIIVNENVECFSENKIDLDGTLFGPCYDPGTDLLRGFDTNISKMKAYPKKSKKEVSKNEIDQVEDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADRRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSKNDIRAFMENQGQFDFDPEKFDFCIHRKKKNQSQKVKQDIVVDTPKKIKTLLPKTKATPITENSLPVPPSTPVTTLLSTSSTSIKDGAVFIGGLRVEMEDSAYKCPKQGCSKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSNNLLEKCNKFGKRKFIQDKSLYVSSSSVTSTLQPISPTAIVPTTVETEDEVDQMEKSNDVQTDDIKMDRMSPSSSHSLDVDDEIEQKQEDTCAMSPGTLFDMKIREEKTQSGIKTLLPVRPAMSSEAQRIDRSKSLDEAIHIDKIKGQRKRQLSEYTSDALNRNKKRHEFPDEYGDLDDSTMDIEGAGPTTPTYRYSRRKSDSRSDENSQSSQLNDLRVEKDDPLKGNIGKKDTNDGEENEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYVCFICRNPYRQRLSKKYFHDQDWIKEGKLPTLSSRTKNEHRFNQRTAMLKRSYDLVAALLHIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKVEVPKPNVTPVPIMEIMKVGKECTDIPSEGFQRTEVKTETKFSLRDDHDEKSIASDSELMKILEEDNITPDESKINGKKEDIHQTKSHILLDALTKNDTSEGKYTNSLPSEVKTDTDLLTNQSDIYENNVSPTTISANHMHEELNEHEMSAPLQPFIPQPEAPIDPGECRMRLLEHIEHFQHHIDAKLTFIEAEVCALEAMDPEDTSTLDVQPRTKQTVQMLVRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-