Basic Information

Gene Symbol
ZFY
Assembly
GCA_034509555.1
Location
CM067411.1:3137422-3140866[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.091 7.1 7.4 1.3 1 23 23 46 23 46 0.86
2 16 2.1e-06 0.00017 22.0 0.6 1 23 52 75 52 75 0.97
3 16 0.00063 0.049 14.2 5.2 3 23 82 103 80 103 0.95
4 16 4.2e-05 0.0033 17.9 0.7 1 23 108 131 108 131 0.97
5 16 2.8e-06 0.00022 21.7 2.2 2 23 138 159 137 159 0.97
6 16 0.0001 0.0078 16.7 1.3 1 23 165 187 165 187 0.97
7 16 4.5e-05 0.0035 17.8 0.5 1 23 193 215 193 215 0.97
8 16 0.0015 0.12 13.1 0.4 2 23 463 485 462 485 0.91
9 16 0.37 29 5.5 0.3 1 23 497 520 497 520 0.95
10 16 0.041 3.2 8.5 3.5 1 23 533 556 533 556 0.93
11 16 4.6e-05 0.0036 17.8 5.9 1 23 562 584 562 585 0.95
12 16 0.01 0.81 10.4 0.3 3 23 592 613 590 613 0.94
13 16 0.00074 0.058 14.0 1.5 1 23 618 641 618 641 0.98
14 16 3.3e-07 2.6e-05 24.5 0.4 2 23 648 669 647 669 0.96
15 16 2.8e-06 0.00022 21.6 1.3 1 23 675 697 675 697 0.97
16 16 3.6e-05 0.0028 18.1 1.0 1 23 703 725 703 725 0.98

Sequence Information

Coding Sequence
ATGATTGCTCACTTGGTACAGAATCACGAAGATTCAGGCGAGAATAGATCAACCAATAACAGGAAATTCGCTTGCATTATTTGTGGTCTTATCTGTTCTCGGAAGGAAACTTTGAGATCTCACTTTGTACGAAAACACACACAGCTTTATGAGTTCTCCTGTGAGCAATGCGGCAAGGAATTCAAGATTAAAGGTGATTTAACGACTCACATGAGACTGAATCACAAAGAACCTCCTGTGATATGCGACGTTTGTGGCAAAACTTGTAAAAATAGTCACAGTCTGTATACTCATCAGAAACACGCTCACTATAAAGCGAAATACGAGTGCCCGGTGTGTCACAAGAGATTGGTGACCAAAGAGAACCTAGATCAGCACGTGTTGACTCAgcacgaaaagaaagagaagtcTGTCTGCGAAGAATGTGGGAAAACATTCTTTGAAAATCACGATTTCAGGAAACACATGAGGATACACACTGGGGATAAACCTTATAGCTGTTCTGTTTGTGCCAGAGCGTTTACTACTCATAGCAGTTTGAGTCAACATTTACTGTTGCACACAGGAGAAAGGATTTATGTCTGCGACGTGTGTGGAAAATCGTTTGCTCAGAAGGCTGGTCTTATATGTCACAGGAAGATCCATTCTGGATCATTGTACGAGCTCGACCACTTCAACTCGCGCGGTATCTTTATCTACGACAAGGAATCGGTCGTGATGAAAAAATGGCAGATCCTGGAATTCGACGGGAAGCCGTACTACGCTTTTGTACCTGAAGACGACACGCCACTAGCTGACGAGGATATTCCCGAACAGATAGACGAGATAGAACACGAGGATGAAAAACAGAATCTCGTCAAAGTCGAATGTCTTTACAACGAAGATGAACTACAGTACGATTCGACGGACGAGAAATTATACGAGGATGAAGATCTTTTAAACAGAAGTACAGAGCacaaggaagaagaagaagaagaagaagatgtaaAACCGATAATTCTAAACGGCACGATTGACGAAGAGAACGACAAAACGATTGGAGATATTTATCAGGTCAAAGTTCAGGGTAGCATGGTCACTATAGAGAAGCTGACATCCGGTGACATCGAAGAGACGAAGGAAGTGGTGGAGTATCAAGAAGTGGAACACGAGGAGCAAGAAGAGCAAGAGGAGCAAGAGGTGCAAGAGGAGCAAGAGGAGCAAGAGGTGCAAGATGTGTATAACGATCAAGAGCAGTTGGAACAGATAGATCAAGTTGATCCGGATGATCCAGATCAGATAGAACAGGTGGAATACTTGGAGGAAGAGATCTTGGAGTTGCCGAATAATCATGCGACACCAACGAAGACGCGTAGGAAAATTTCCAGAAGTCCGAGCAATGCACTGAAATGCAAACTTTGCTCGGAGATGTTCAGCTCGGCCATTTCCTTCAGGAAACATGTGGCATGGACGCACAAGAAGAAGGTGTGCATACAGGAAGATGGCGCGTATATCTGCGCGGTTTGCGATTACAGGACGCTTAAGAAGAGTCTCTTCGCGGCTCACTTGGAAAGGAAGCACGAAACTTGGTCCAGGAAACGACCCAATAACATGTTATTCCCTTGCGCTGCCTGTGGCTTTGTATGCAGATCGAAGCACTCGTTGCAATCGCACTTTATTAGAAAACACACCGATCGGTACGAGCATCAGTGCAAATTTTGTCCAAAGAAGTTCAAAGTGAAAGGCGACCTGACCAACCACATACGGTTCCACCATAAAGAAAAACCGATTAACTGTCCCGTATGTGGAAAACTATGTCAAAATACTGGCTCTCTTTACGTACACCAGAAATGGGCACATTTTAAACCTAAGTACGAGTGTCATATATGCAAACGACGCATGGTCACACAGGAAAATCTTGACCAACATCTGCTAACGCAGCAcgagaaaagggagaagatAGTATGCGCCGAATGCGGAAAAACTTTCActaaaaaagattcttttaaaAGGCACATGGCAGTGCACACAGGGTGCAAGCCACATTCCTGTCTAATCTGCAATAAACCATTCGCGAGGAGGTCTCAGCTACGCCAACATTTGCTCATTCACACTGGGAAGAGGCCTTTTGTCTGCGACATTTGTGGGAAAGCGTTCACGCAGAAACCCGGTCTGATCTGTCATAGGAAAACTCATCCTGGACCTCATCCTCCTTTACCTGTGATGCCAATTGCGGATATCGTGAAAGAGTTCACCGAAGGTTACGTACAGGAGATAAGCGCACGTGAAAACGAGGAAAGGATCGAAGAGGAAGCGTAG
Protein Sequence
MIAHLVQNHEDSGENRSTNNRKFACIICGLICSRKETLRSHFVRKHTQLYEFSCEQCGKEFKIKGDLTTHMRLNHKEPPVICDVCGKTCKNSHSLYTHQKHAHYKAKYECPVCHKRLVTKENLDQHVLTQHEKKEKSVCEECGKTFFENHDFRKHMRIHTGDKPYSCSVCARAFTTHSSLSQHLLLHTGERIYVCDVCGKSFAQKAGLICHRKIHSGSLYELDHFNSRGIFIYDKESVVMKKWQILEFDGKPYYAFVPEDDTPLADEDIPEQIDEIEHEDEKQNLVKVECLYNEDELQYDSTDEKLYEDEDLLNRSTEHKEEEEEEEDVKPIILNGTIDEENDKTIGDIYQVKVQGSMVTIEKLTSGDIEETKEVVEYQEVEHEEQEEQEEQEVQEEQEEQEVQDVYNDQEQLEQIDQVDPDDPDQIEQVEYLEEEILELPNNHATPTKTRRKISRSPSNALKCKLCSEMFSSAISFRKHVAWTHKKKVCIQEDGAYICAVCDYRTLKKSLFAAHLERKHETWSRKRPNNMLFPCAACGFVCRSKHSLQSHFIRKHTDRYEHQCKFCPKKFKVKGDLTNHIRFHHKEKPINCPVCGKLCQNTGSLYVHQKWAHFKPKYECHICKRRMVTQENLDQHLLTQHEKREKIVCAECGKTFTKKDSFKRHMAVHTGCKPHSCLICNKPFARRSQLRQHLLIHTGKRPFVCDICGKAFTQKPGLICHRKTHPGPHPPLPVMPIADIVKEFTEGYVQEISARENEERIEEEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01418482;
90% Identity
iTF_00223339;
80% Identity
-