Basic Information

Insect: Bombus opulentus
Gene Symbol: MBD-R2
Assembly: GCA_034509555.1
Location: CM067417.1:11318115-11329180[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.7e-17 1.5e-13 50.2 0.2 6 69 542 605 537 613 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.7e-17	1.5e-13	50.2	0.2	6	69	542	605	537	613	0.90

Sequence Information

Coding Sequence: ATGAAGCGACGACGTGTAGCGTCGCATGTTAAAAGGATATCGCTTGTGAGAACAATGAGAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAGGCCGATGTGCAAGATGTGCGTACTAGAGGGTTACCGCttcataaatttccaaaagatattaatttaaggAACAGATGGTTGACTAGTGGTGGATTCGAAGCGAGCTTTAAACCTTCACCAGGTCAGGTTGTTTGTCATAGACACTTCAAACGAGCTGACTACGAAGCTGCTAAAGGACATAAATTACTTCTACGTAAGGGTAGCGTTCCGTCGGTTTTTGCAGATTATGACAATCATCCAGATCCTGTAATTATGTCTGTAAAATCATCAACTTCCTATGCGCAAGAAGATTTAGATCTTATTAATTCTGAAATTCTGAACTTAGAACAATCTACCTCTTCAATGAATTCTGGTCTCAGAACATTAAAGTCTAATAATTGTGGAGAAACATGTTCGTCTCGACCGGAACCATCAGTTAATTCCTTCAATTTACTAGATTCATCAGAATTACTTGATAATGGATGTAAGAACATTaatgtgaaagaagaaaatgtatataatgtgAAAcaagagataaataaaaattcagaaatagaAGTGAATTCTATGGCAGTGCAATTAGGTATTGTTGAATCTGATATAGCAATAAAACATATACAAAAAGATTTGGCCATTAAGGAAGAATTGAAAAGTATGGAAGTGGAAGATGAAAAAACATTTGATAAACCAGAAGAACTTAAaccaaaaatttttaatcgaggTGGACTAAAATTTTTTCCCGGAGCCAAATTGGAAGCGAaagatttcaatgaaaaatgGTATTCAGCGAAAGTAGTTGAAACTGATTGGGATGAACGAGAAGTATTGATACGTTTTGACAAGTGGAGTTCAAGGTTTGATGAATGGATACCTATGGATAGTTCAAGATTACGTGTATTGCAAACACAATCaaacgAACAAACCTGGAATCTACCATCTCAggaaacaaaaatgaaagacTTTTCAATGGGAGAAAGGATACTTGCTACGTGGGCTGATGGTAGAAAATATCCTGCTAAAGTAAATGCCGTCTTAGGAAACGaTAAATATGATGTACTGTTTGATGATGGATATACAAAGACAATTAAATCGtcaaaaatgacaaaaattgcTACAACAGTCACAAAGCAACCTAGTCAAACTGAAGAATATATAGGAAGCAAGCAAGAAAGaagagataagaaaagaaagcataCAGTAATGGAGTTATTTCATACACATTATAGAAAACgttcaaaaaatgaaacagataaattaataaaaaaggaaggaattatagttaatgaaaatgttgaatGCCAttcggaaaataaaattgatttagatGGAACTTTATTTGGGCCCTGCTATGATCCAGGCACAGATTTATTACGTGGGTTTGACACCAATGTGTCTAAAATGAAAGCTTATcctaaaaaaagtaaaaaggaagTATCTAAGAATGAAATAGATCAAGTAGAAGATGTGGGTCCTGAATGGATTGATGGAGAACCTCAGGGAACTGAATCTTATATAGTGGATGGAAATGATGGACCACGTCGATCAATAATAGTTGCAGACAGAAGATTACCGCCTGGATGGCAAAAACATTTTACTCAAAGAAAAGCTGGTACATCAGCTGGAAAATGGGATGtcttatttcttcataaatcAAGTGGGAAAAAATTTAGatcaaaaaatgatattagggcatttatggaaaatcaGGGGCAATTCGACTTTGAtccagaaaaatttgatttttgcattcatcgaaaaaagaaaaatcaaagtCAAAAAGTAAAACAAGATATCGTTGTGGATACTCCAAAAAAAATTAAGACTTTATTGCCTAAAACAAAGGCAACACCAATAACTGAGAATTCTTTATCTGTTCCCCCAAGTACACCAGTTACAACATTATTACCTACATCAAGTACATCTATTAAAGATGGTGCTGTTTTTATTGGTGGACTTCGAGTAGAAATGGAGGACAGTGCTTATAAATGTCCGAAACAAGGGTGTAGTAAAACATTTAGGAAGGAAAATCTTCTACAAATGcatataaaacattatcatccagaatattcgaaatttttggGATCTACACCAAATGTTGCAGATTTAGCTTATGCAAGAACAATTGGGGAATCTGTTGAAGATATTATTCCAAAAAAGTCaaataatttgttagaaaagtgcaataaatttggaaagagaaaatttattcaagatAAATCATTGTATGTTTCATCATCTTCTGTAACAAGCACTCTTCAACCTATATCGCCAACAGCAATTGTACCAACAACAGTAGAAACAGAGGATGAAGTAGACCAAATGGAAAAATCCAATGATGCGCAAACAGACGATATTAAAATGGATAGAATGTCTCCAAGTTCTAGTCATAGTTTAGATATGGATGATGAAGTAGAACAAAAACAGGAAGATACATGTGCAATGTCACCAGGAACACTATTTGATATGAAAATTAGGGAAGAAAAAACGCAAAGTGGCATTAAGACACTTCTTCCGGTAAGACCAGCCATGTCTTCAGAATCACAGCGAATTGATAGATCAAAGTCTTTAGATGAAGCTATTCATATCGACAAAATTAAAGGACAAAGGAAACGACAATTATCAGAATATAGTTCTGATGCATTAAACAGAAGTAAAAAGCGACATGAATTTCCGGACGAGTATGGCGAGTTAGATGATAGTACTATGGATATAGAAGGAACAGGACCGACTACACCCACGTATAGATATAGTCGCAGAAAATCAGATTCAAGAAGTGATGAAAATAGCCAAAGTAgTCAACTAAATGATTCGCGTGTTGAAAAAGATGATCCCTTGAAAGGGAATATTGGTAAAAAAGATACTAATGATGGGGAAGAGAATGAAGGAGTTATGATGATGATCAATGGTGAAATGGTGAAAGTTGAGCAGCTTCGTAgggaagaaataataaattgcacTTGTGGATTTATGGAAGAAGATGGATTAATGATTCAATGCGACCTTTGTTTGTGTTGGCAACATGGTCACTGCAATGcaatagaaaaggaaaaggacgTACCTGAGAaatatgtttgttttatttgtagaaatcCATATCGGCAACGATTatccaaaaaatattttcacgatcaAGATTGGATAAAAGAGGGAAAGTTACCAACATTATCTAGCCGAACAAAAAATCAGCATCGAGTTAATCAAAGAATAGCTATGTTAAAACGTTCTTATGATCTAGTTGCTGCTCTTTTACACATTCAGCAAGTTTTACACAGTTTAAGAGTAAAAATCAATGTAGCTCAaaagaaagatcaTCCAAAGCTATATCTGTGGGCCAAAAATTGGGAAAAAGTTGAAGTACCAAAACCAAATGTCACACCAGTACCAATCATGGAGATTATGAAAGTAGGAAAAGAGTGTACAGAAATTCCAAGTGAAACTGAAGTAAAAACTGAAACAAAGTTCAGTTTAAGAGATGATCATGATGAAAAGTCGATAGCCTCAGATTCAGAATTAATGAAGATATTagaagaagataatataaCTCCAGATGAATCTAAAATTAACGgcaaaaaagaagatattataCATCAAACTAAAAGTCATATTCTTCTCGATGCACTTACGAAAAATGATACTTCAGAAGGGAAATATACAAACTCATTACCTTCAGAGGTGAAAACAGATAgagatttgtTAACCAATCAATCAGATATATACGAGAATAACGTATCTCCCACAACTATATCAGCGAATCACATGCATGAAGAACTAAATGAACATGAAATGTCAGCACCGTTGCAACCTTTCATACCACAACCAGAAGCGCCAATTGACCCAGGAGAATGTCGAATGCGATTAATAGAACACATAGAACATTTTCAACATCATATAGATgcaaaattaacatttatcgAGGCAGAAGTTCGTGcTTTAGAAGCCATGGATCCTGAAGATATATCTACCTTAGATGTTCAGCCTCGAACTAAACAAACGGTTCAAATGCTTGTTCGAGATTTAAACACCGTGCGAAAATTAGCTGCTTTGtgttga
Protein Sequence: MKRRRVASHVKRISLVRTMRMARKCCVRSCEADVQDVRTRGLPLHKFPKDINLRNRWLTSGGFEASFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSVPSVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSTSSMNSGLRTLKSNNCGETCSSRPEPSVNSFNLLDSSELLDNGCKNINVKEENVYNVKQEINKNSEIEVNSMAVQLGIVESDIAIKHIQKDLAIKEELKSMEVEDEKTFDKPEELKPKIFNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIRFDKWSSRFDEWIPMDSSRLRVLQTQSNEQTWNLPSQETKMKDFSMGERILATWADGRKYPAKVNAVLGNDKYDVLFDDGYTKTIKSSKMTKIATTVTKQPSQTEEYIGSKQERRDKKRKHTVMELFHTHYRKRSKNETDKLIKKEGIIVNENVECHSENKIDLDGTLFGPCYDPGTDLLRGFDTNVSKMKAYPKKSKKEVSKNEIDQVEDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADRRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSKNDIRAFMENQGQFDFDPEKFDFCIHRKKKNQSQKVKQDIVVDTPKKIKTLLPKTKATPITENSLSVPPSTPVTTLLPTSSTSIKDGAVFIGGLRVEMEDSAYKCPKQGCSKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSNNLLEKCNKFGKRKFIQDKSLYVSSSSVTSTLQPISPTAIVPTTVETEDEVDQMEKSNDAQTDDIKMDRMSPSSSHSLDMDDEVEQKQEDTCAMSPGTLFDMKIREEKTQSGIKTLLPVRPAMSSESQRIDRSKSLDEAIHIDKIKGQRKRQLSEYSSDALNRSKKRHEFPDEYGELDDSTMDIEGTGPTTPTYRYSRRKSDSRSDENSQSSQLNDSRVEKDDPLKGNIGKKDTNDGEENEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYVCFICRNPYRQRLSKKYFHDQDWIKEGKLPTLSSRTKNQHRVNQRIAMLKRSYDLVAALLHIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKVEVPKPNVTPVPIMEIMKVGKECTEIPSETEVKTETKFSLRDDHDEKSIASDSELMKILEEDNITPDESKINGKKEDIIHQTKSHILLDALTKNDTSEGKYTNSLPSEVKTDRDLLTNQSDIYENNVSPTTISANHMHEELNEHEMSAPLQPFIPQPEAPIDPGECRMRLIEHIEHFQHHIDAKLTFIEAEVRALEAMDPEDISTLDVQPRTKQTVQMLVRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01539602;
90% Identity: iTF_00216442;
80% Identity: iTF_00223923;