Bign017611.1
Basic Information
- Insect
- Bombus ignitus
- Gene Symbol
- Runx1
- Assembly
- GCA_014825875.1
- Location
- CM026156.1:4638070-4639971[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.8e-52 1.7e-48 163.8 0.0 5 93 93 181 89 186 0.97
Sequence Information
- Coding Sequence
- ATGACGAATCCTTTACGAGATGCACGCCCCGAGGATCGGCCTCTAGGCTTAGATTATCCGGATCCGAGATTGGTTCGAAACGGTCATCAGGACCATCAAGGGAACTCGACGCATCAGATAGGTGGCGGGAGAATTAGGAGAACCAGGACCTCGTCATCGAGGAGAAGAATGCACCTGGCCAACGAGGTCCCTCCACAAGGATCTACTGGTGGAAATAATATACCGGATTATGCACTCACCGCGGATCTGCTCGCCGAGAGGACTTTGGATGGCCTGTTTGCTGAACATCCTGGAGAACTTGTGCGAACAGGCTCGCCACACGTGGTCTGTACGGTGCTACCGCAACATTGGCGGTCAAACAAGACACTTCCGGTAGCGTTCAAGGTAGTAGCTCTGGGCGAGGTCGGTGATGGGACTCTGGTGACAGTGCGTGCCGGAAATGATGAAAATTGCTGCGCGGAATTGCGAAATTCCACGGCGGTTATGAAGAACCAGGTGGCGAAATTCAACGATCTTAGGTTCGTCGGTAGAAGCGGAAGAGGTGGTGGGCCGACTGATGGCCTCGTTTTTCCTCGGACGCGAGGCGAGGAGAACCAGCTGGCCCCTCCGTTTCATCCTCATTTTTAA
- Protein Sequence
- MTNPLRDARPEDRPLGLDYPDPRLVRNGHQDHQGNSTHQIGGGRIRRTRTSSSRRRMHLANEVPPQGSTGGNNIPDYALTADLLAERTLDGLFAEHPGELVRTGSPHVVCTVLPQHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCCAELRNSTAVMKNQVAKFNDLRFVGRSGRGGGPTDGLVFPRTRGEENQLAPPFHPHF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00215489;
- 90% Identity
- iTF_00226375; iTF_00220364; iTF_00222319; iTF_00216856; iTF_00225023; iTF_00961607; iTF_01418792; iTF_01419428; iTF_01420078; iTF_00218893; iTF_00140367; iTF_00141618; iTF_01539383; iTF_00217536;
- 80% Identity
- iTF_00225023;