Bcam003216.1
Basic Information
- Insect
- Bombus campestris
- Gene Symbol
- Runx1
- Assembly
- GCA_905333015.1
- Location
- HG995145.1:5667628-5668556[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 4.7e-54 1.6e-50 169.9 0.0 5 100 93 188 89 194 0.95
Sequence Information
- Coding Sequence
- ATGACGAATCCTTTACGAGATGCACGCCCCGAGGATCGGCCTCTAGGCTTAGATTATCCGGATCCGAGATTGGTTCGAAACGGTCATCAGGACCATCAAGGAAACTCGACGCATCAGATCGGTGGCGGGAGAATTAGGAGAACCAGGACCTCGTCATCGAGGAGAAGAATGCACCTGGCCAACGAGGTCCCTCCACAAGGATCCACTGGTGGAAATAATATACCGGATTATGCACTCACCGCGGATCTGCTCGCCGAGAGGACTTTGGATGGCCTGTTTGCTGAACATCCTGGAGAACTTGTGCGAACAgGCTCACCACACGTGGTCTGTACGGTGCTACCGCAACATTGGCGATCAAACAAGACACTTCCGGTAGCGTTCAAGGTAGTAGCTCTGGGCGAGGTCGGTGATGGGACTCTGGTGACAGTGCGTGCCGGAAATGATGAAAATTGCTGCGCGGAATTGCGAAATTCCACGGCGGTTATGAAGAACCAGGTGGCGAAATTCAACGATCTTAGGTTCGTCGGTAGAAGCGGAAGAGGTAagatatttccatattttataCTCCTCTACTTCTTCCCCatataa
- Protein Sequence
- MTNPLRDARPEDRPLGLDYPDPRLVRNGHQDHQGNSTHQIGGGRIRRTRTSSSRRRMHLANEVPPQGSTGGNNIPDYALTADLLAERTLDGLFAEHPGELVRTGSPHVVCTVLPQHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCCAELRNSTAVMKNQVAKFNDLRFVGRSGRGKIFPYFILLYFFPI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01419428; iTF_00226375; iTF_01418792; iTF_00220364; iTF_01420078; iTF_00140367; iTF_00222319; iTF_00227058; iTF_00224339; iTF_00216856; iTF_00675801; iTF_00231099; iTF_00219582; iTF_00225023; iTF_00961607; iTF_00763022; iTF_00221039; iTF_00141618; iTF_00233015; iTF_00223658; iTF_00229811; iTF_01539383; iTF_00359995; iTF_00360689;
- 90% Identity
- iTF_00229811;
- 80% Identity
- iTF_00225023;