Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_014737535.1
Location
JACXIX010000015.1:2556662-2568939[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.27 1.7e+03 -1.2 0.0 44 68 435 459 433 462 0.93
2 2 3.8e-18 2.3e-14 52.8 0.3 6 69 542 605 537 613 0.90

Sequence Information

Coding Sequence
ATGAAGCGACGACGTGTAGCGTCGCATGTTAAAAGGATATCGCTTGTGAGAACAATGAGAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAGGCCGATGTGCAAGATGCGCGTGCTAAAGGGTTACCGCTTCATAAATTTCCAAAAGATATTAATTTAAGGAACAGATGGTTGACTAGTGGTGGATTCGAAGCGAGCTTTAAACCTTCACCAGGTCAGGTTGTTTGTCATAGACACTTCAAACGAGCCGACTATGAAGCTGCTAAAGGACATAAATTACTTCTACGTAAGGGCAGCATTCCGTCGGTTTTTGCAGACTATGACAATCATCCAGATCCTGTAATTATGTCTGTAAAATCATCAACTTCTTATGCACAGGAAGATTTAGATCTTATTAATTCTGAAATTCTGAACTTAGAACAATCTACCTCTTCACAGAATTCTGGTCTCAGAACATTAAAGTCTAATAATTGTGGAGAAACATGTTCTTCTCGACCAGAACCATCAGTTAATTCCTTCAATTTACTAGATTCAACAGAATTACTTGATAATGGATGTAAGAACTTTAATGTGAAAGAAGAAAATGTATCTACTGTGAAACAAGAGATAAATAAAAATTCAGAAATAGAAGTGAATACTATGGCAGTGCAATTAGGCATTGTTGAATCTGATATAGCAATAAAACATATACAAAAAGATTTGGCCATTAAGGAGGAACTGAAAAGTATGGAAGTGGAAGATGAAAAAACATTTGATAAACCAGAAGAATTAAAACCAAAAATTTTTAATCGAGGTGGACTAAAATTTTTTCCTGGAGCCAAATTGGAAGCGAAAGATTTTAATGAAAAATGGTATTCAGCGAAAGTAGTTGAAACTGATTGGGATGAACGAGAAGTATTGATACGTTTCGACAAGTGGAGTTCAAGGTTTGATGAATGGATACCTATGGATAGCTCAAGATTACGTGTATTGCAAACACAATCAAACGAACAAACCTGGAATCTACCATCTCAGGAAACAAAAATGAAAGACTTTTCAATGGGGGAAAGGATACTTGCTACGTGGGCTGATGGTAGAAAATATCCAGCTAAAGTAAATGCCGTCTTAGGAAACGATAGATATGATGTACTGTTTGATGATGGATATACAAAGACAATTAAATCGTCAAAAATGACAAAAATCGCTACAACAGTCACAAAGCAACCTAGTCAAACTGAAGAATATATAGGAAGCAAGCAAGAAAGAAGAGATAAGAAAAGAAAGCATACAGTGATGGAGTTATTTCATACACATTATAGAAAACGTTCAAAAAATGAAACAGATAAATTAATAAAAAAGGAAGGAGCTATAGTTAATGAAAATGTAGAATGCTTTTCCGAAAATAAAATTGATTTAGATGGAACTTTATTTGGGCCTTGCTATGATCCAGGCACAGATTTATTACGTGGATTTGACACCAATGTATCTAAAATGAAAGCTTATCCTAAAAAAAGTAAAAAGGAAGTATCTAAGAGTGAAATAGATCAAGTAGAAGATGTGGGTCCTGAATGGATTGATGGAGAACCTCAGGGAACTGAATCTTATATAGTGGATGGAAATGATGGACCACGTCGATCAATAATAGTTGCAGACAAAAGATTACCACCTGGATGGCAAAAACATTTTACTCAAAGAAAAGCTGGTACATCGGCTGGAAAATGGGATGTCTTATTTTTTCATAAATCAAGTGGAAAAAAATTTAGATCAAAAAATGATATTAGGGCATTTATGGAAAATCAGGGGCAATTCGATTTTGATCCAGAAAAATTTGATTTTTGCATTCATCGAAAAAAGAAAAATCAAAGTCAAAAAGTAAAACAGGATATCGTTGTGGATACTCCAAAAAAGATTAAGACTTTATTGCCTAAAACAAAGGCAACACCAATAACTGAGAATTCTTTACCCGTTCCCCCAAGTACACCAGTTACAACATTATTATCTACATCAAGTACATCTATTAAAGATGGTGCTGTTTTTATTGGTGGACTTCGAGTAGAAATGGAGGACAGTGCTTATAAATGTCCGAAACAAGGGTGTAGTAAAACATTTAGGAAGGAAAATCTTCTACAAATGCATATAAAACATTATCATCCAGAATATTCGAAATTTTTGGGATCTACACCAAATGTTGCAGATTTAGCTTATGCAAGAACAATTGGGGAATCTGTTGAAGATATTATTCCAAAAAAGTCAAATAATTTGTTAGAAAAGTGCAACAAATTTGGAAAGAGAAAATTTATTCAAGATAAATCATTGTATGCTTCATCATCTTCTGTAACAAGCACTCTTCAACCAACTTTATCACCAACAACAATTGTACCAACAACAGTAGAAACAGAGGATGAAGTAGACCAAATGGAAAAATCCAATGATGTGCAAACAGACGATATTAAAATGGATAGAATGTCTCCAAGTTCTAGTCATAGTTTAGATATGGATGATGAAATTGAACAAAAACAGGAAGATACATGTGCAATGTCACCAGGAACACTATTTGATATGAAAATTAGGGAAGAAAAAACGCAAAGTGGCATTAAGACACTTCTTCCAGTAAGACCAGCCATATCTTCAGAAGCACAGCGAATTGATAGATCAAAGTCTTTAGATGAAGCTATTCATATCGACAAAATAAAAGGTCAAAGGAAACGACAATTATCAGAATATAGTTCTGATGCATTAAACAGAAATAAAAAGCGACATGAATTTTCGGACGAGTATGGTGATTTAGATGATAGTACTATGGATATAGAAGGAGCAGGACCGACTACACCCACGTATAGATATAGTCGCAGAAAATCAGATTCAAGAAGTGATGAAAATAGCCAAAGTAGTCAACTAAACGATTCGCGTGTTGAAAAAGATGATCCCTTGAAAGGGAATATTGGTAAAAAAGATACTAATGATGGGGAAGAGAATGAAGGAGTTATGATGATGATCAATGGTGAAATGGTGAAAGTGGAGCAGCTTCGTAGAGAAGAAATAATAAATTGCACTTGTGGATTTATGGAAGAAGATGGTTTAATGATTCAATGCGACCTTTGTTTGTGTTGGCAACATGGTCACTGCAATGCGATAGAAAAGGAAAAGGATGTACCTGAGAAATATGTTTGTTTTATTTGTCGGAATCCATATCGGCAACGATTATCCAAAAAATATTTTCACGATCAAGATTGGATAAAAGAGGGAAAGCTACCAACATTATCTAGCCGAACAAAAAATCAGCATCGAGTTAATCAAAGAACAGCTATGTTAAAACGTTCTTATGATCTAGTTGCTGCCCTTTTACACATTCAGCAAGTTTTACACAGTTTAAGAGTAAAAATCAATGTAGCTCAACAGAAAGATCATCCAAAGCTATATCTGTGGGCCAAAAATTGGGAAAAAGTTGAAGTACCAAAACCAAATGTTACACCAGTACCAATCATGGAGATTATGAAAGTAGGAAAAGAGTGTACAGATATTCCAAGTGAAGGTTTTCATCGAACTGAAGTAAAAACGGAAACAAAGTTCAGTTTAAGAGATGATCATGATGAAAAGTCGATAGCCTCAGATTCAGAATTAATGAAGATATTAGAAGAAGATAATATAACTCCAGATGAATCTAAAATTAACGGCAAAAAGGAAGATATTATACATCAAACTAAAAGTCATATTCTTCTCGATGCACTTACGAAAAATGATACTTCAGAAGGAAAATGTACAAACTCATTACCTTCAGAGGTGAAAACAGATACAGATTTGTTAACCAACCAATCAGATATATACGAAAATAACGTATCTCCGGCAACTATATCAGCGAATCACATGCATGAAGAACTAAATGAACATGAAACGTCAGCACCGTTGCAACCTTTCATACCACAACCAGAAGCGCCAATTGACCCAGGAGAATGTCGAATGCGATTATTAGAACACATAGAACATTTTGAACATCATATAGATGCAAAATTAACATTTATCGAGGCAGAAGTTTGTGCTTTAGAAGCTATGGATCCTGAAGATACATCTACCTTAGATGTTCAGACGCGAACTAAACAAACGGTACAAATGCTTGTTCGAGATTTAAACACCGTGCGAAAATTAGCTGCTTTGTGTTGA
Protein Sequence
MKRRRVASHVKRISLVRTMRMARKCCVRSCEADVQDARAKGLPLHKFPKDINLRNRWLTSGGFEASFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSIPSVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSTSSQNSGLRTLKSNNCGETCSSRPEPSVNSFNLLDSTELLDNGCKNFNVKEENVSTVKQEINKNSEIEVNTMAVQLGIVESDIAIKHIQKDLAIKEELKSMEVEDEKTFDKPEELKPKIFNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIRFDKWSSRFDEWIPMDSSRLRVLQTQSNEQTWNLPSQETKMKDFSMGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYTKTIKSSKMTKIATTVTKQPSQTEEYIGSKQERRDKKRKHTVMELFHTHYRKRSKNETDKLIKKEGAIVNENVECFSENKIDLDGTLFGPCYDPGTDLLRGFDTNVSKMKAYPKKSKKEVSKSEIDQVEDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFFHKSSGKKFRSKNDIRAFMENQGQFDFDPEKFDFCIHRKKKNQSQKVKQDIVVDTPKKIKTLLPKTKATPITENSLPVPPSTPVTTLLSTSSTSIKDGAVFIGGLRVEMEDSAYKCPKQGCSKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSNNLLEKCNKFGKRKFIQDKSLYASSSSVTSTLQPTLSPTTIVPTTVETEDEVDQMEKSNDVQTDDIKMDRMSPSSSHSLDMDDEIEQKQEDTCAMSPGTLFDMKIREEKTQSGIKTLLPVRPAISSEAQRIDRSKSLDEAIHIDKIKGQRKRQLSEYSSDALNRNKKRHEFSDEYGDLDDSTMDIEGAGPTTPTYRYSRRKSDSRSDENSQSSQLNDSRVEKDDPLKGNIGKKDTNDGEENEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYVCFICRNPYRQRLSKKYFHDQDWIKEGKLPTLSSRTKNQHRVNQRTAMLKRSYDLVAALLHIQQVLHSLRVKINVAQQKDHPKLYLWAKNWEKVEVPKPNVTPVPIMEIMKVGKECTDIPSEGFHRTEVKTETKFSLRDDHDEKSIASDSELMKILEEDNITPDESKINGKKEDIIHQTKSHILLDALTKNDTSEGKCTNSLPSEVKTDTDLLTNQSDIYENNVSPATISANHMHEELNEHETSAPLQPFIPQPEAPIDPGECRMRLLEHIEHFEHHIDAKLTFIEAEVCALEAMDPEDTSTLDVQTRTKQTVQMLVRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01539602;
90% Identity
iTF_00216442;
80% Identity
iTF_00217792;