Basic Information

Insect: Bombus breviceps
Gene Symbol: MBD-R2
Assembly: GCA_014825925.1
Location: CM026188.1:11504618-11514672[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.1 4.3e+03 -2.8 0.0 44 68 435 459 432 461 0.91

2 2 1.5e-17 6e-14 51.2 0.2 6 69 542 605 537 613 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.1	4.3e+03	-2.8	0.0	44	68	435	459	432	461	0.91
2	2	1.5e-17	6e-14	51.2	0.2	6	69	542	605	537	613	0.91

Sequence Information

Coding Sequence: ATGAAGCGACGACGTGTAGCGTCGCATGTTAAAAGGATATCGCTTGTGAGAACAATGAGAATGGCGCGCAAATGTTGCGTGCGTAGCTGTGAGGCCGATGTGCAAGATGCGCGTGCTAAAGGGTTACCGCttcataaatttccaaaagatattaatttaaggAACAGATGGTTGACTAGTGGTGGATTCGAAGCGAGCTTTAAACCTTCACCAGGTCAGGTTGTTTGTCATAGACACTTCAAACGAGCCGACTACGAAGCTGCTAAAGGACATAAATTACTTCTACGTAAGGGCAGCGTTCCGTCGGTTTTTGCAGACTATGACAATCATCCCGATCCTGTAATTATGTCTGTAAAATCATCAACTTCTTATGCACAGGAAGATTTAGATCTTATTAATTCTGAAATTCTGAACTTAGAACAATCTACCTCTTCATTGAATTCTGGTCTCAGAACATTAAAGTCTAATAATTGTGGAGAAACATGTTCTTCTCGACCAGAACCATCAGTTAATTCCTTCAATTTACTAGATTCAACAGAATTACTTGATAATGGGTGTAAGAACTTTAATGTGAAggaagaaaatgtatatactgTGAAAcaagagataaataaaaattcagaaatagaAGTGAATACTATGGCAGTACAATTAGGCATTGTTGAATCTGATATAGCAATAAAACATATACAAAAAGATTTGGGCATTAAAGAAGAACTGAAAAGTATGGAAGTGGAAGATGAAAAAACATTTGATAAACCAGAAGAATTAAAaccaaaaatttttaatcgaggTGGACTAAAATTTTTTCCTGGAGCCAAATTGGAAGCGAaagatttcaatgaaaaatgGTATTCAGCGAAAGTAGTTGAAACTGATTGGGATGAACGAGAAGTACTGATACGTTTCGACAAGTGGAGTTCAAGGTTTGATGAATGGATACCTATGGATAGTTCAAGATTACGTGTATTGCAAACACAATCAaacgAACAAACCTGGAATCTACCATCTCAggaaacaaaaatgaaagacTTTTCAATGGGGGAAAGGATACTTGCTACGTGGGCTGATGGTAGAAAATATCCAGCTAAAGTAAATGCCGTCTTAGGAAACGATAGATATGATGTACTATTTGATGATGGATATACAAAGACAATTAAATCGtcaaaaatgacaaaaatcgCTACAACAGTCACAAAGCAATCTAGTCAAGCTGAAGAATATATAGGAAGCaaacaagaaagaagagaTAAGAAGAGAAAGCATACAGTGATGGAGTTATTTCATACACATTATAGAAAACGttcaaaaaatgaaacagataaattaataaaaaaggaaggaatcatagttaatgaaaatgtagaatgcttttcggaaaataaaattgatttggATGGAACTTTATTTGGGCCTTGCTATGATCCAGGCACAGATTTATTACGTGGGTTTGATACCAatgtatctaaaataaaagcttatcctaaaaaaagtaaaaaggaagTATCTAAGAGTGAAATAGATCAAGTAGAAGATGTGGGTCCTGAATGGATTGATGGAGAGCCTCAGGGAACTGAATCTTATATAGTGGATGGAAATGATGGACCACGTCGATCAATAATAGTTGCAGACAAAAGATTACCACCTGGATGGCAAAAACATTTTACTCAAAGAAAAGCTGGTACATCAGCTGGAAAATGGGATGTcttatttcttcataaatcaagtggaaaaaaatttagatcaaaaaatgatattagggcatttatggaaaatcaGGGGCAATTCGACTTTGATccagaaaaatttgatttttgcattcatcgaaaaaagaaaaatcaaagtcAAAAAGTAAAACAAGATATCGTTGTGGATACTCCAAAAAAGATTAAAACTTTATTGCCTAAAACAAAGGCAACACCAATAACTGAGAATTCTTTACCTGTTCCCCCAAGTACACCAGTTACAACATTATTATCTACATCAAGTACATCTATTAAAGATGGTGCTGTTTTTATTGGTGGACTTCGAGTAGAAATGGAGGACAGTGCTTATAAATGTCCGAAACAGGGGTGTAGTAAAACATTTAGGAAGGAAAATCTTCTACAAATGcatataaaacattatcatccagaatattcgaaatttttggGATCTACACCAAATGTTGCAGATTTAGCTTATGCAAGAACAATTGGGGAATCTGTTGAAGATATTATTCCAAAAAAGTCAAATAATTTGTTAGAAAAGTGCAATAAAtttggaaagagaaaatttattcaagaTAAATCATTGTATGTTTCATCATCTTCTGTAACAAGCACTCATCAACCTATATCGCCAACAGCAATTGTACCAACAACAGTAGAAACAGAGGATGAAGTAGACCAAATGGAAAAATCCAATGATGTGCAAACAGACGATATTAAAATGGATAGAATGTCTCCAAGTTCTAGTCATAGTTTAGATATGGATGatgaaattgaacaaaaaCAGGAAGATACGTGTGCAATGTCACCAGGAACACTATTTGATATGAAAATTAGGGAAGAAAAAACGCAAAGTGGCATTAAGACACTTCTTCCGGTAAGACCAGCCATGTCTTCAGAAGCACAGCGAATTGATAGATCAAAGTCTTTAGATGAAGCTATtcatatcgacaaaataaaagGTCAAAGGAAACGACAATTATCAGAATATAGTTCTGATGCATTAAACAGAAGTAAAAAGCGACATGAATTTCCGGACGAGTATGGTGATTTAGATGATAGTACTATGGATATAGAAGGAGCAGGACCGACTACACCCACGTATAGATATAGTCGCAGAAAATCAGATTCAAGAAGTGATGAAAATAGCCAAAGTAgTCAACTAAACGATTCGCGTGTTGAAAAAGATGATCCCTTGAAAGGGAATATTGGTAAAAAAGATACTAATGATGGGGAAgAGAATGAAGGAGTTATGATGATGATCAATGGTGAAATGGTGAAAGTGGAGCAGCTTCGtagagaagaaataataaattgcacTTGTGGATTTATGGAAGAAGATGGTTTAATGATTCAATGCGACCTTTGTTTGTGTTGGCAACATGGTCACTGCAATgcaatagaaaaggaaaaggatgTACCTGAGAAATATGTCTGTTTTATTTGTCGGAATCCATATCGGCAACGATTatccaaaaaatattttcacgatcaAGATTGGATAAAAGAGGGAAAGCTACCAACATTATCTAACCGAACAAAAAATCAGCATCGAGTTAATCAAAGAACAGCTATGTTAAAACGTTCTTATGATCTAGTTGCTGCTCTTTTACACATTCAACAAGTTTTACACAGTTTAAGAGTAAAAATCAATGTAGCTCAaaagaaagatcaTCCAAAGCTATATCTGTGGGCCAAAAATTGGGAAAAAGTTGAAGTACCAAAACCAAATGTTACACCAGTACCAATCATGGAGGTTATGAAAGTAGGAAAAGAGTGTACAGATATTCCAAGTGAAGGTTTTCATCGAACTGAAGTAAAAACGGAAACAAAGTTCAGTTTAAGAGATGATCATGATGAAAAGTCGATAGCCTCAGATTCAGAATTAATGAAGATATTAGAAGAAGATAATATAGCTCCAGATGAATCTAAAATTAACGGCAAAAAGGAAGATATTATACATCAAACTAAAAGTCATATTCTTCTCGATGCACTTACGAAAAATGATACTTCAGaaggaaaatatacaaactCATTACCTTCAGAGGTGAAAACAGATACagatttgtTAACCAATCAATCAGATATATACGAGAATAACGTATCTCCGACAACTATATCAGCGAATCACATGCATGAAGAACTAAATGAACATGAAATGTCAGCACCGTTGCAACCTTTCATACCACAACCAGAAGCGCCAATTGACCCAGGAGAATGTCGAATGCGATTATTAGAACACATAGAACATTTTCAACATCATATAGATgcaaaattaacatttatcgAGGCAGAAGTTTGTGCTTTAGAAGCTATGGATCCTGAAGATACATGTACCTTAGATGTTCAGCCCCGAACTAAACAAACGGTTCAAATGCTTGTTCGAGATTTAAACACCGTGCGAAAATTAGCTGCTTTGTGTTga
Protein Sequence: MKRRRVASHVKRISLVRTMRMARKCCVRSCEADVQDARAKGLPLHKFPKDINLRNRWLTSGGFEASFKPSPGQVVCHRHFKRADYEAAKGHKLLLRKGSVPSVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEQSTSSLNSGLRTLKSNNCGETCSSRPEPSVNSFNLLDSTELLDNGCKNFNVKEENVYTVKQEINKNSEIEVNTMAVQLGIVESDIAIKHIQKDLGIKEELKSMEVEDEKTFDKPEELKPKIFNRGGLKFFPGAKLEAKDFNEKWYSAKVVETDWDEREVLIRFDKWSSRFDEWIPMDSSRLRVLQTQSNEQTWNLPSQETKMKDFSMGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYTKTIKSSKMTKIATTVTKQSSQAEEYIGSKQERRDKKRKHTVMELFHTHYRKRSKNETDKLIKKEGIIVNENVECFSENKIDLDGTLFGPCYDPGTDLLRGFDTNVSKIKAYPKKSKKEVSKSEIDQVEDVGPEWIDGEPQGTESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRKAGTSAGKWDVLFLHKSSGKKFRSKNDIRAFMENQGQFDFDPEKFDFCIHRKKKNQSQKVKQDIVVDTPKKIKTLLPKTKATPITENSLPVPPSTPVTTLLSTSSTSIKDGAVFIGGLRVEMEDSAYKCPKQGCSKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSNNLLEKCNKFGKRKFIQDKSLYVSSSSVTSTHQPISPTAIVPTTVETEDEVDQMEKSNDVQTDDIKMDRMSPSSSHSLDMDDEIEQKQEDTCAMSPGTLFDMKIREEKTQSGIKTLLPVRPAMSSEAQRIDRSKSLDEAIHIDKIKGQRKRQLSEYSSDALNRSKKRHEFPDEYGDLDDSTMDIEGAGPTTPTYRYSRRKSDSRSDENSQSSQLNDSRVEKDDPLKGNIGKKDTNDGEENEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYVCFICRNPYRQRLSKKYFHDQDWIKEGKLPTLSNRTKNQHRVNQRTAMLKRSYDLVAALLHIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKVEVPKPNVTPVPIMEVMKVGKECTDIPSEGFHRTEVKTETKFSLRDDHDEKSIASDSELMKILEEDNIAPDESKINGKKEDIIHQTKSHILLDALTKNDTSEGKYTNSLPSEVKTDTDLLTNQSDIYENNVSPTTISANHMHEELNEHEMSAPLQPFIPQPEAPIDPGECRMRLLEHIEHFQHHIDAKLTFIEAEVCALEAMDPEDTCTLDVQPRTKQTVQMLVRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01539602;
90% Identity: iTF_00216442;
80% Identity: iTF_00215067;