Basic Information

Gene Symbol
ZFX
Assembly
GCA_905231865.2
Location
HG993146.1:2263042-2264415[-]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 0.0007 20 6.1 0.3 17 49 161 194 148 197 0.82
2 5 0.0053 1.5e+02 3.2 0.6 21 44 226 249 221 257 0.86
3 5 1.5e-07 0.0044 17.8 0.1 26 45 287 306 281 314 0.90
4 5 0.041 1.2e+03 0.4 0.1 27 53 316 342 306 343 0.76
5 5 0.00088 25 5.7 0.0 21 48 363 390 357 393 0.92

Sequence Information

Coding Sequence
ATGACCGATATTAGTTGCCGTTTATGCTTCGAAAACACTGGTGTCATTTCAATTTATAATAGTAACGAAAATGAAATTAACGCAAAAATATCGTATTGTTGCGTGAATATTAGTATCAGAGAAAATGATGGTTTACCTTCATACATTTGTAACTTTTGCGAATCTCAACTTACTGCTTGTTATGAATTTTTAGTTAAGTGTGAAGAGACCGACAAAAAATTGCGTTTAATTAGAGTTAATAAACCTGACAAAGAATATGGTTTAAAAATTGATATAAAACCAGAAATAGATCACAACTTAGATGACGGAAATGAGAACTCCTTCGAAACACCTGATGAAATTAAGCAAGAAATCGATTGGAAAGACGTACTGAAGGAAAAATATCGAAGTTTTAAGAAAAGAAAAAGTAAAATTTCTAGCATTACCAAATGTACTATATGTGGTAGAAAATGTGCAAACCCTTCTACTCTTGCTATACATATGAGATCTCATACAAATGAAAGGCCATATTCTTGTCAATTTTGTGATAAAACCTACAAAGATGGTGGGAGTCTTAAACGACATATACAGAGAAATCATTTAAGAGACAAACGTGAAAGATCATTTATTTGTGAGAATTGTGGAAAAGGCTTTTTCTCAAAAAGTGAAGTTAAAATACACATGCGTATACATACAGGAGAAACACCATATGCTTGTTCAGCGTGTCCTGCCAGGTTTACTCAAATAAGTACCTTACAAAGACATCAGCGTCGACACACTGGAGAGAGAACCCATATATGCCTAACATGCCACAAAACGTTTTGTACCAAAGATGAATTAAAATCACACTTTACTGTGCATTCAACAGTGAAAAAGTTTAAGTGTCCAATATGTTATGCATTATTTAAATATAAGAATAATTTAAGAAAACATATGAGAAACCATTCAGATGCAGAAAAGTTTATTTGCAATTACTGTGGACGTAACTTTACTATGAAAGGTAATTTAAAGATACATATTGAGAGATTGCACTCATCAAAGTCAGGATATTGTAATGTATGTTTAAAAAGTGTGTCTAATATTGAGGTTCATATGTGGAAACATACTGGTGAGAGGCCCCTGAAATGTGAGTTTTGTGCAAAAAGTTTTGCTGAAAAAAATGCTTTGGCTCGGCATATTAATTTTAGGCATAAAAATACAGATAGATATAAATGTACTGTTGATGGTTGTTCTGTTAAGTTTCCCTCAAGACCAATGTTAGATTTTCATGTAGCAAAACTACATGGAACAATAAAACCGTTTCAATGTGATAAATGTTCAAGAGGCTTCTATAGGAAAAGTGATTTAGCTAGACATAAGATAGGTACACATAAAGAGAAACTCATACTAGTTTGA
Protein Sequence
MTDISCRLCFENTGVISIYNSNENEINAKISYCCVNISIRENDGLPSYICNFCESQLTACYEFLVKCEETDKKLRLIRVNKPDKEYGLKIDIKPEIDHNLDDGNENSFETPDEIKQEIDWKDVLKEKYRSFKKRKSKISSITKCTICGRKCANPSTLAIHMRSHTNERPYSCQFCDKTYKDGGSLKRHIQRNHLRDKRERSFICENCGKGFFSKSEVKIHMRIHTGETPYACSACPARFTQISTLQRHQRRHTGERTHICLTCHKTFCTKDELKSHFTVHSTVKKFKCPICYALFKYKNNLRKHMRNHSDAEKFICNYCGRNFTMKGNLKIHIERLHSSKSGYCNVCLKSVSNIEVHMWKHTGERPLKCEFCAKSFAEKNALARHINFRHKNTDRYKCTVDGCSVKFPSRPMLDFHVAKLHGTIKPFQCDKCSRGFYRKSDLARHKIGTHKEKLILV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00160068;
90% Identity
iTF_00212808; iTF_00213792;
80% Identity
iTF_00213792;