Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 9.8 4.4e+03 -1.3 0.0 43 69 149 172 142 172 0.68

2 3 5e-20 2.2e-17 64.0 0.6 3 105 169 271 167 276 0.91

3 3 0.2 90 4.1 0.1 77 108 275 306 271 308 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	9.8	4.4e+03	-1.3	0.0	43	69	149	172	142	172	0.68
2	3	5e-20	2.2e-17	64.0	0.6	3	105	169	271	167	276	0.91
3	3	0.2	90	4.1	0.1	77	108	275	306	271	308	0.87

Coding Sequence: atgaatacagATTTGGACGTATTGgaTAGCGAGGTGATATTTGGACATCGGCCTTGTCAAACTCGCCAAGTAAAATGGATTTTAATCGATAAGTTTTATGAGAAAtgttttagaccaaatttttatgatattggTGGTTCATATATAGAAGAAATTGCAGATTTATGGTTTAATTGTAAAACTGAAATTGttggcaaaatatttttagttcacCTGTTTGTTGTTAACCGATTACAAGATCAAGTGAATTTGTCAATAGCCAGTAAAAACAACATATTGTTAAAAAAGAAACATCATTCAGCATTCTTAACTTCAGTGCATAAAACCTATGAATTTAACGATACCCCAGCTCTCTCATGTAACTATATCTTAACCTATAGCTTTTCAGAGGCAGACATAGAACTATTAAAaggtttaaatttatatatatctgtaactttaaaaaagaaaaaagaattaaGTAGCCATGTAAAggataaagtattaaaaacacaaGATTTTAAAGCACTATTAAATGATCCTGTGTGCTCAGATTTTGTTATTGAATCAGCTGATGGTGTTAAATTCAATGTTCATGAAGTTATATTGACTGCTAATAGTGAAGTATTTAAAGCAATGCTTAAAGAAAATACAGCTGAAAGTCAAAATAGGTGTATGAAAATGATAGATGTAGAGAGCGAGGATCTTAAAcacataatacattatatttacacAGGTACGTTAGAAAATCTGGATAACTGTAACTTTATTAACCTAATGATGTTAGGAGacaagtataatttaaaaggcTTAGaagaattatgtaaaaatgGTCTCATGTGTCAACTGAATAGGGAAAATGTTTTTGAAACACTTGTAATTGCAGATTTATATAATTGTGATGAATTAAAAATGGCAGCTCTTaagtacataaaaaattataaagttaaactTGAAAATAGTTTGTTTGAGGAACTCGACAATATCAAATTAGTTAAAGAGCTTTGTACATTTCTCTCTTGTAGCTTTTAA
Protein Sequence: MNTDLDVLDSEVIFGHRPCQTRQVKWILIDKFYEKCFRPNFYDIGGSYIEEIADLWFNCKTEIVGKIFLVHLFVVNRLQDQVNLSIASKNNILLKKKHHSAFLTSVHKTYEFNDTPALSCNYILTYSFSEADIELLKGLNLYISVTLKKKKELSSHVKDKVLKTQDFKALLNDPVCSDFVIESADGVKFNVHEVILTANSEVFKAMLKENTAESQNRCMKMIDVESEDLKHIIHYIYTGTLENLDNCNFINLMMLGDKYNLKGLEELCKNGLMCQLNRENVFETLVIADLYNCDELKMAALKYIKNYKVKLENSLFEELDNIKLVKELCTFLSCSF

Sequence clustering based on sequence similarity using MMseqs2