Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 9e-11 2.9e-06 27.7 0.1 3 81 43 123 41 181 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	9e-11	2.9e-06	27.7	0.1	3	81	43	123	41	181	0.73

Coding Sequence: ATGGAACAGTTAATTAAATGCAGGTACGACAAGTGGGACCGGGGCGGGGGAGGaggcgcgggcggcgcgtgGACAGGCCGCGAGCCGCGCGACGCCCGCGAACCCCGTGCCGAGCCGCGCGACACTCGCGATCGCGAGCGCGACCGCGAACGCGAGCGTCAAGCACGTGCCCACCAAATGTCCAATGCTCACGCGGCCGAGCCGGACGCCTCGTCACTCTTCCCTGCACCATTTAGAGTGACAGGCAACAGAGATCGTGTTAGCCAACAGATCCAAATCAAGCTCGGCGACTACCGGCTCGCGCAGACGCTACTCGACGACCCCAGCAAGTCCATCGGAATCTGTGCCGAACCACCAAGTCCTGCTCCATggaaggATTATTGTGGAGACTTGATTTCATACGTCACTGAacgttccgtgtccacttcTCCCAGTTCTGCGCAAAACTCAATGCTCGCCGAGGTGTTTCAAATTCGGGCGAGTGAGCGTGCGCGTAGAAATCGTTCAGTGAGGGAGGGTATCGCTCATATCAGGCACCTCACTGACGAGGCTCTGCTCTGGCCATGGGAGGAAGACTTTAGGGACTTCGGCGGCTGGCCTAGTGACGATGGGTGCGGTTCTTCCGTACCCATCTCACTGGGTCAGGAGACCACACGGCATCCTGACACTGCGGCGAAAAGTTGA
Protein Sequence: MEQLIKCRYDKWDRGGGGGAGGAWTGREPRDAREPRAEPRDTRDRERDRERERQARAHQMSNAHAAEPDASSLFPAPFRVTGNRDRVSQQIQIKLGDYRLAQTLLDDPSKSIGICAEPPSPAPWKDYCGDLISYVTERSVSTSPSSAQNSMLAEVFQIRASERARRNRSVREGIAHIRHLTDEALLWPWEEDFRDFGGWPSDDGCGSSVPISLGQETTRHPDTAAKS

Sequence clustering based on sequence similarity using MMseqs2