Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.016 74 4.2 0.1 22 43 84 105 77 109 0.85

2 8 0.00095 4.5 8.1 0.0 17 53 106 143 104 144 0.85

3 8 0.3 1.4e+03 0.1 0.1 21 42 139 160 135 165 0.74

4 8 0.0019 8.8 7.2 0.1 21 46 167 192 159 200 0.86

5 8 0.17 8.1e+02 0.9 0.2 21 31 195 205 190 218 0.78

6 8 0.00018 0.86 10.4 0.0 10 52 211 254 205 256 0.85

7 8 0.41 1.9e+03 -0.3 0.1 21 43 251 273 249 275 0.77

8 8 0.0002 0.96 10.3 0.0 21 46 279 304 266 308 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.016	74	4.2	0.1	22	43	84	105	77	109	0.85
2	8	0.00095	4.5	8.1	0.0	17	53	106	143	104	144	0.85
3	8	0.3	1.4e+03	0.1	0.1	21	42	139	160	135	165	0.74
4	8	0.0019	8.8	7.2	0.1	21	46	167	192	159	200	0.86
5	8	0.17	8.1e+02	0.9	0.2	21	31	195	205	190	218	0.78
6	8	0.00018	0.86	10.4	0.0	10	52	211	254	205	256	0.85
7	8	0.41	1.9e+03	-0.3	0.1	21	43	251	273	249	275	0.77
8	8	0.0002	0.96	10.3	0.0	21	46	279	304	266	308	0.85

Coding Sequence: ATGGAAAGGACAGATGTCGGTGAAAACAACACTGAAGAGGACAATTTATCAACATGTGTGAATTGTGCTGGAAAGTTTCAAGTTCAAATCAAGATCTCCAATCCTAAGATGTGCAAAAGCTGCAGTTCAGAACATAAAATTGATCATGATGTACCAAAACTTTTATCCGAAGGGAAACCTCATGCTTGTTCTAGATGTGGAAAGCATTTCAACCGACTTTGGGCTTTGAAGAAACACTACTGCATGACAGAAAAACTCTATGTATGTGAAGTGTGTGGGAAACAGTTTGCTCAATCACGTAATTTGCTTGTCCATTCTCGTTCACATACAGGTGAAAAACCATTTACATGTAGCACTTGTAATAAAAGCTTCTCTTACTCTGGAGACTTAAAGATTCATATACGTATTCATACTGGTGAAAAGCCTCATGTATGTGATGTGTGTAACAAATCATTTTCGAAACAAGGTAAATTGAAGATACATTATCGAATTCATACTGGTGAAAAACCATATGTTTGTAAAGTTTGTAAGAAAGCATTTTCCGAATCTCAAGTGTTGAAAAGACATTACCATACTCATACTGGAGAAAAGCCACATCAGTGTTCTATTTGTATGAAAGGCTTCACTAAACCtggaaaattgaaaattcattatCGAAGCCACACAGGAGAGAAACCTTATATCTGTGCCATTTGTAATAAAGGATTTTCTGAAGCTCAAGTTTTGAAAAAACATCTTCGCATCCATACAGGGGAGAAACCATACATCTGTTCTGTATGCCAGAAAAGGTTTAATGACACACAAGTTCTAAAAGAACATTACAGAACACATTCTGGGGAGAAACCATATATGTGTAGTGTGTGTATGAAATGTTTTACTTTCTCAAAATCTCTGaagaaacattttgaaattcacACAGGTCACTCAGTAGTACATCAGTAA
Protein Sequence: MERTDVGENNTEEDNLSTCVNCAGKFQVQIKISNPKMCKSCSSEHKIDHDVPKLLSEGKPHACSRCGKHFNRLWALKKHYCMTEKLYVCEVCGKQFAQSRNLLVHSRSHTGEKPFTCSTCNKSFSYSGDLKIHIRIHTGEKPHVCDVCNKSFSKQGKLKIHYRIHTGEKPYVCKVCKKAFSESQVLKRHYHTHTGEKPHQCSICMKGFTKPGKLKIHYRSHTGEKPYICAICNKGFSEAQVLKKHLRIHTGEKPYICSVCQKRFNDTQVLKEHYRTHSGEKPYMCSVCMKCFTFSKSLKKHFEIHTGHSVVHQ

Sequence clustering based on sequence similarity using MMseqs2