Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 8 3.7e+03 -1.0 0.1 71 104 93 127 90 132 0.83

2 3 3.2e-23 1.5e-20 74.3 0.4 8 109 182 283 175 284 0.91

3 3 4.5 2.1e+03 -0.2 0.0 80 107 286 313 282 315 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	8	3.7e+03	-1.0	0.1	71	104	93	127	90	132	0.83
2	3	3.2e-23	1.5e-20	74.3	0.4	8	109	182	283	175	284	0.91
3	3	4.5	2.1e+03	-0.2	0.0	80	107	286	313	282	315	0.80

Coding Sequence: ATGGAAAACATGAAATTGGACAATAAGATTACAACGTCGGAAAAAGCCGATGTGATATTTGGCCATGACCGATGTCAAACTCAAGCCGCGAGGTGGATGTGCATTGATAACATATATCAGAAGTTACACCGACCCAACTACTTTGATATTGGCGGAACATACATCCAAGACGTGGCTGACCATTGGTTTATTTTTAAAACTGAACAAGTAGGGAATATATTCTTGCTACATTTATTTATGAATAATCGCCAAGAAGGGTTATTCTCTGTTTCTGTAAGTCATAACAGTGAATTAAAATTAGATAAGAAGAATGCAGTAGCATATTTGCCAACAATGTTGAAAAAATGCCAGATCCTTAATCCTAAGGAAAAGTGCATATACATAAATACTTACAGCTTTTCAGAATTTGAAGTGGACTTGTTGAAAAACATGAAGCTTTATATTGCAATTTCTTTCTCTGAATCAAGTGAAGTGAAAAGTTTAAATCAAGATATTATAGATAGTATAAAAATGGAACATGATTTTGCTGCCTTGTTAAGTGACCCTATTTGTTCAGATTTTATTATCGAGTCTGGCGACGGAGAGAAATTTAAGGTTCACAAAGTGCTGTTGAGTACCCACAGTGAAGTGTTCAAGGCCATGCTGAAGGAAGACACCGCCGAGTGCCAGAATGGCTATGTTAAATTAATGGACGTTAGTTCAGAAGATCTGGCCTTTATCTTGGAGTTCATTTATACTGGAACCCTGAAGGATGATGAAAATTGCAATTTTATTAATTTACTCACTTTGGCTGATCAATACAACATAGTAGGCCTAAAAGAACTGTCACAATATGCTCTTATTCAGCATTTAAATATAGAGAATGCCACAGAGACGTTGGTAGTCGCTGATATGTACAACTCTGATTTTGTGAAGATTAATGCACTCAATTTTATTAAGAAATACCCTACAGTGCTTAAAAGTGATCAATTCAAAGAATTAAAAAATGTAGATCTTATTAGAGAGGTTTGTCAGTACATAGCTTCTCCATTATAA
Protein Sequence: MENMKLDNKITTSEKADVIFGHDRCQTQAARWMCIDNIYQKLHRPNYFDIGGTYIQDVADHWFIFKTEQVGNIFLLHLFMNNRQEGLFSVSVSHNSELKLDKKNAVAYLPTMLKKCQILNPKEKCIYINTYSFSEFEVDLLKNMKLYIAISFSESSEVKSLNQDIIDSIKMEHDFAALLSDPICSDFIIESGDGEKFKVHKVLLSTHSEVFKAMLKEDTAECQNGYVKLMDVSSEDLAFILEFIYTGTLKDDENCNFINLLTLADQYNIVGLKELSQYALIQHLNIENATETLVVADMYNSDFVKINALNFIKKYPTVLKSDQFKELKNVDLIREVCQYIASPL

Sequence clustering based on sequence similarity using MMseqs2