Basic Information

Gene Symbol
Hr39
Assembly
GCA_907269095.1
Location
OU026119.1:17174758-17193455[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 0.11 1.9e+03 -1.2 3.2 105 163 253 313 132 340 0.60
2 5 6.4e-08 0.0011 19.4 0.1 1 20 443 462 443 469 0.91
3 5 0.012 2e+02 2.0 0.0 76 118 486 525 462 544 0.79
4 5 5e-29 8.5e-25 88.9 0.3 201 265 542 615 492 624 0.75
5 5 4.7e-32 7.9e-28 98.9 0.0 289 408 658 783 650 783 0.93

Sequence Information

Coding Sequence
ATGAACCCCGCGATGGCCAGTGAGGGGGACCCCGTGAAGGTGGAAGGGGGGCACGTGTCCGTTACCACGATCAGCATGTCCGGACCGGAGACCAGCAATGGCCAGTTTTCCTACAGCTCCAGTGGAGTTCGCATCAGCGTGTCCTCGGAGCCCCACGACGAAGACTCGACTGACGCAGAGATCTCCAAGATCGACTTCTCGCAACACCAGTACGAGGTGAACATGAGGAACAAGAAGAAGCGCTCGTCCAGCGGCACTCTCTGCGAGCAGGGCAGCGACCGCGAGCGGCCCATGTCCTGGGAGGGCGAGCTGTCCGACTCCGAGATGGTTATCGACACCAGCGTTAATAACGACGAGAACAGCAACTCCTTAGACCTCCAATCGTCTCGGGATTCCATAGACACGCTACGCAACGTCACCATAAAGACGGAGCCCCTGAAGACGGAGCCCTTCCAGAGCCTGGATGACCAGCGTGTCCTGGACCTGAAGTACACAGCACCCTTGCAGCCCTACCAGCGGAGTCTCAGTATGAATAGGATATCAGTGCTAACGGATAACGCGTCCCTCTCGCTCCCGCGGCGGCCGTCGTCCCCCACGAGCAGCGCCAAGTCGTTGATCCTCGACCAGAACACGATGCTGCTGCCGATGATGGCTCACACGGCCATTGGGGAGGTCCAGAACCTAACGATCAAGAAGGAGACACAGTTATCTGAGCTGAAATGCGAGCCCCCATCCGGCATGGAGAAGCTGACGGGAGCACTGCACGGCTCGCCGCTGCTGGGAAGGCTGCCGCGCGTGCAGTCCAGTGCTAGCACGGACTCCGCTGTGCATTCCATGTACACGCATAGCGTATACAGCAGTCCCTCGGCCAGTCCGCGCGCGTCGCGACACTACACGCCGTCTCTCTCTCGCAACAACAGTGACGCATCGCACTCTTCTTGTTACTCCTATAGCTCGGAGTTTTCGCCGACACATTCGCCGGTACAGAGCCGCCACCCGCACGTGGTATACCGCGATCCCGGGGTATTCCCTGCGTCTCCTGACGACGAGCCCGAACCACCTGACGACCGTCCGCTGCACCACCAGGGCATCAGCCGACAGCAGCTTATCAACAGCCCATGCCCGATATGCGGCGACAAGATCAGCGGCTTCCACTACGGCATATTCTCCTGCGAGTCCTGCAAGGGATTCTTCAAGCGCACTGTGCAGAATCGCAAGAACTACATGTGTCTGCGCGGGGGCAACTGCCCCGTTACCGTGGCAACGAGGAAGAAGTGCCCAGCTTGCCGGTTCGACAAGTGTTTGGGGTGCGGGATGAAGCTTGAGGCGATCCGTGAAGACCGCACCCGTGGCGGGCGCTCGACCTACCAGTGCTCGTACTCGCTGTCCGGCGCCGCGTCCACCGGCTCGCTGCTGCCCGCGCCGCCGCCCGCGCTCCGACACGCCTCCAGCCTCACCTGCGTGAACGGTCCAGGGTCGTACAGCCGCGGGGAATCCAGCAACAGCCGGCTCACGCCCGATATTCCACCATTATTGCAGGAAATAATGGACGTGGAACACCTCTGGCAGTACAACGAGTCCGAGCTAAACCGGCTTGGCAAGACCCCCGGCAGTCCTTCAGCCAATCCTCTTCTCGCTGCCAGCGGCATCACAGCACAGAACTCCAGTCCTGACTTCCTGGCAGACCTCTGCAATATCGCGGACCATCGCCTCTACAAGATCGTCAAATGGTGCAAGAGCCTGCCGCTGTTTAAGAATATCTCGATCGACGACCAGATCTGCCTGCTGATAAACAGCTGGTGCGAGCTGCTGGTGCTGTCGTGCTGCTACCGCGGCGTGGCCACGCCCGGCGAGCGGCTGTCTACACTCTGTGGGCTGGGGTCAATGATCGCTAACGCTAATCCATATGGCATATACTATAGTTACTATAGCACACAGCACACTTACTATGTACACGGCACATTAACAAGATCACTGGGCCTGCAGCCGTGCATCGAGCGCATGCTGAGCTTCACGGACCACCTGCGGCGGTTGCGTGTCGACCGCTACGAGTACGTCGCTCTCAAGGTCATCGTTCTGCTCACGTCCGACGCGCCAGAGCTCCGCGAGTCGGAGAAGGTGCGCGCGTCGCAGGAGAAGGCGTTGGCCGCGCTGCAGGCGTACACGGCCGCGCACTCGCCGCAGGCGCCCGCCAAGTTCGGCGAGCTGCTGCTGAGGATACCCGAGCTGCAGCGCACATGCCAGTTCTTCATGCAAGTCGGCAAAGAGATGCTCAACCCAGCGAACAAGAACAAAGACGGCGAAGGGCCAAGCTTCAACCTCCTCATGGAGCTCTTGAGAGGGGACCACTGA
Protein Sequence
MNPAMASEGDPVKVEGGHVSVTTISMSGPETSNGQFSYSSSGVRISVSSEPHDEDSTDAEISKIDFSQHQYEVNMRNKKKRSSSGTLCEQGSDRERPMSWEGELSDSEMVIDTSVNNDENSNSLDLQSSRDSIDTLRNVTIKTEPLKTEPFQSLDDQRVLDLKYTAPLQPYQRSLSMNRISVLTDNASLSLPRRPSSPTSSAKSLILDQNTMLLPMMAHTAIGEVQNLTIKKETQLSELKCEPPSGMEKLTGALHGSPLLGRLPRVQSSASTDSAVHSMYTHSVYSSPSASPRASRHYTPSLSRNNSDASHSSCYSYSSEFSPTHSPVQSRHPHVVYRDPGVFPASPDDEPEPPDDRPLHHQGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYMCLRGGNCPVTVATRKKCPACRFDKCLGCGMKLEAIREDRTRGGRSTYQCSYSLSGAASTGSLLPAPPPALRHASSLTCVNGPGSYSRGESSNSRLTPDIPPLLQEIMDVEHLWQYNESELNRLGKTPGSPSANPLLAASGITAQNSSPDFLADLCNIADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLVLSCCYRGVATPGERLSTLCGLGSMIANANPYGIYYSYYSTQHTYYVHGTLTRSLGLQPCIERMLSFTDHLRRLRVDRYEYVALKVIVLLTSDAPELRESEKVRASQEKALAALQAYTAAHSPQAPAKFGELLLRIPELQRTCQFFMQVGKEMLNPANKNKDGEGPSFNLLMELLRGDH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01386822;
80% Identity
iTF_00208003;