Basic Information

Gene Symbol
-
Assembly
GCA_947172395.1
Location
OX359222.1:7651905-7654839[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.00025 0.014 16.0 3.3 1 23 172 195 172 195 0.97
2 17 8.8e-05 0.0048 17.5 0.6 1 23 204 227 204 227 0.96
3 17 0.035 1.9 9.3 0.3 2 23 240 262 240 262 0.97
4 17 0.00019 0.01 16.4 1.1 1 23 271 294 271 294 0.97
5 17 5.8e-05 0.0032 18.0 1.4 1 23 306 329 306 329 0.97
6 17 5.3e-05 0.0029 18.1 0.8 2 23 363 385 362 385 0.97
7 17 0.00056 0.03 14.9 0.9 2 23 395 417 394 417 0.96
8 17 0.33 18 6.2 0.5 2 20 422 440 421 442 0.92
9 17 0.0012 0.063 13.9 3.7 2 21 447 466 446 469 0.94
10 17 0.0028 0.15 12.7 1.3 3 23 479 500 478 500 0.96
11 17 0.0009 0.049 14.3 2.6 1 23 505 528 505 528 0.95
12 17 0.0054 0.29 11.8 1.8 2 23 539 561 538 561 0.96
13 17 0.016 0.89 10.3 0.6 1 23 588 611 588 611 0.94
14 17 4.2 2.3e+02 2.7 0.1 2 23 618 638 617 638 0.83
15 17 0.0073 0.4 11.4 0.9 2 23 645 666 644 666 0.97
16 17 0.021 1.1 10.0 0.1 1 23 732 754 732 754 0.97
17 17 0.21 11 6.8 2.0 1 23 760 783 760 783 0.96

Sequence Information

Coding Sequence
ATGTCGATTAAAGATGAGAAATCTGATATAAAAAATTTAAAAATTGAGAAAAAAGATGGTGACAAAAGAAAAGATCCCACTTCATTCTTGCCAGAAGAAGCAATGTCGTACGAAATCAAGTCAAAGAAAAAGAAGAAGAAAAAAAAGAAAGACCTAACAGAAGACCCATTTAAAGATATAGAGGAGAAAGTCACTTTGCCGACTCCAACATTTTACGACCCGACTGGAGATATCGACCCAGAACCAGTCCACCATTTGGATCCAGAAGTAAATATAAAGGTTGAGAATATTGAAGTGGAGTTGGATTTTAATGATTTTGCAAATGATAACGGTTTAATGGTGGAGGGACCTCAGAGTGAAGATAGCCAAGAACCGGCTGTGAAGATCGAAGATCATAACCATGAAGCAGTGCTTCTAACTTTTGAAAGTATACTTAAAGACAAGAGCATGCTTGGTCTAGTTCCAGATGAAAATGTTTTAGGATTCAGCGCCATTACAGCTCCCGCGCCGAATTTTGTGTGCAAAGTCTGCCATCTAGTCTTTCAAACTCCGAAAACATTGAGAATGCATCAAAAAAGAAAGCACAAGTCCTATCGAAAGTCCTTTAAACATATATGTGATTACTGTGGGATGGCGTACGAACAAAAAAACAGTTTGGTGGCACATATAAAAAGAAAACACGGACCTGATTCAGTACCTGATGATTTGGAAGAGAGGACGTGCGACGTATGTGCCCTAGTTTTCAAAGGAATTGCAAGATTGCGCATGCACATGCGAAGAAAGCACGGTTCTTTCGAAGAGTCCTTTAAATATATATGTGACGAATGTGGACTGACATACGACAAGCATAGAAGCTTAATTGTGCATATGCAAAGAAAACATTCGAACGAACCCAAACCAGTGCTGGATACGTGGTACAATTGTCCATTTTGTCCCAAAGTATTTACTAAAAGAGAGACTTACGTGAGACACGTACAGCGAAAGCATAGGATAAATGACGATGATGATAAGAAGAAAGAAGAAGAACTAGGAACTGAAGGAATGAAGGAATTGTTGCATTGCAAGAATGAACAAACGGGAGAGATAACTTGCAAAGAGTGTCCGCTAGTTTTTTCGTCATTGAACTTCTTGAAGTTGCATATGAGAAGGAAACATAATGCGCTAAAAGATGACTTCAGGTTGAAATGTATGATATGCAATCTGTCGTATGATAAAGTTGAAAGTTTAAAACGTCACATCAGAAGAAAGCACGATAAAGGAACATACTGTGATGTTTGTGAGATACAGTTCGAAACTCGCGATATGTATCTCCAACACACACACAAAAGAATGATCCAAGAATGCCACATATGTGGTCTCGTTTTCGCTTCTAGAGGGGGTTTGTGTAAACATTTGCGATGTACGCACAAAATCGAAGCGCCTAAAACTGTCTTCTGTGATATTTGCGGCGAAAGTTTTCACGATAAACGTCAATTAAAACCTCATTACATGAAGGTCCATTTGAAAGTATCGTACACCTGTCGATATTGTAAGAAAATATTTAGGGCAAAGGAAAGTTACAGACGTCACGTTCTGTTGAAACATCCAAACCAGAGTCAGAGTCAGAATCAGCAGAAATGCGATCACTGTCCAGAAACGTTCTTGGATGAATTCGAACTGTGTAAACATATCAACATAGCGCATCGAGTGCAGAAAGGCAACGAAATTGGTGCTATGACATTAATAGAGGTGAAGAAGGAAGAAATGGACATACCAGCGACATTTCAATGCACGAAATGTCCAGACAACTATGACAGTTGGGAGCAACTGAAATTGCACTATGAGCAAAATCATCAGAAAATATCCAACACACAGTGCCAGGTTTGTGGTGAGATGGTGCCTGAATTGGAAATACAGAAACATATCAAAGTACACAGTAATGATACTAAGGTACAGTGTAGATATTGTGAATTCGAAACGTCGAATCGTGCCAGTATGACACAACATATGCTGAGACATAAAAACGCGACAACTTTACACTGTGACTTCAACGGTTGCAGGTACAAAACTTATTACGAACGTGCCATGGAGAAGCATAAGAGGAAACACGAAGATTTAGGCCTCAAATTGCAATGTACGCAATGTCCTTTCCAAACCATGAATAAATACATTCTGAGATATCACGAGGAAGCTCACGTGACTGGCAAAAAGAGGTATATGTGCGACCAGTGTGACTATGCGACCATTTTACCTGCAAACTTAGTTCAACACAAATACAAACATTCATCAGAAAAACGGTTCAAGTGTGAAGTCTGTCCGTTCGCGACGAAGTACAACACGTCGCTGCGTTTTCACGTTAAGAAAAAACACTGTGATCTCCCTACATTCAAGTTAATTACAAAATGA
Protein Sequence
MSIKDEKSDIKNLKIEKKDGDKRKDPTSFLPEEAMSYEIKSKKKKKKKKKDLTEDPFKDIEEKVTLPTPTFYDPTGDIDPEPVHHLDPEVNIKVENIEVELDFNDFANDNGLMVEGPQSEDSQEPAVKIEDHNHEAVLLTFESILKDKSMLGLVPDENVLGFSAITAPAPNFVCKVCHLVFQTPKTLRMHQKRKHKSYRKSFKHICDYCGMAYEQKNSLVAHIKRKHGPDSVPDDLEERTCDVCALVFKGIARLRMHMRRKHGSFEESFKYICDECGLTYDKHRSLIVHMQRKHSNEPKPVLDTWYNCPFCPKVFTKRETYVRHVQRKHRINDDDDKKKEEELGTEGMKELLHCKNEQTGEITCKECPLVFSSLNFLKLHMRRKHNALKDDFRLKCMICNLSYDKVESLKRHIRRKHDKGTYCDVCEIQFETRDMYLQHTHKRMIQECHICGLVFASRGGLCKHLRCTHKIEAPKTVFCDICGESFHDKRQLKPHYMKVHLKVSYTCRYCKKIFRAKESYRRHVLLKHPNQSQSQNQQKCDHCPETFLDEFELCKHINIAHRVQKGNEIGAMTLIEVKKEEMDIPATFQCTKCPDNYDSWEQLKLHYEQNHQKISNTQCQVCGEMVPELEIQKHIKVHSNDTKVQCRYCEFETSNRASMTQHMLRHKNATTLHCDFNGCRYKTYYERAMEKHKRKHEDLGLKLQCTQCPFQTMNKYILRYHEEAHVTGKKRYMCDQCDYATILPANLVQHKYKHSSEKRFKCEVCPFATKYNTSLRFHVKKKHCDLPTFKLITK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01021537;
90% Identity
-
80% Identity
-