Basic Information

Gene Symbol
Aef1
Assembly
GCA_951812415.1
Location
OX638310.1:54621835-54622332[-]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.028 1.7e+02 3.4 0.2 22 46 33 57 28 59 0.87
2 4 1.3e-05 0.078 14.1 0.1 21 51 60 90 58 91 0.88
3 4 0.0042 24 6.1 0.0 21 51 88 118 86 119 0.87
4 4 9e-05 0.53 11.4 0.1 21 46 116 141 114 146 0.90

Sequence Information

Coding Sequence
ATGTCCGTCGAATTAGTAACGATCTACATCAATACCTTGCATGATCCTATGTCTCGTGCATTAAGCCGTACAATGACTGTAGCTAATGGTTCTGTGGACAAACCGTTCCAATGTAACGTATGCGAAAGACGTTTCCGTCAATTGAGTACCCTAACGAATCACGTTAAAATCCATACCGGCGAAAAGCCCTACAAATGTTCAATATGCGAAAAACATTTCCGACAATCCAGCACACTAACGAATCACTTGAAAATTCATACGGGCGAAAAACCATTCAATTGTACGTATTGCGGTAAACAATTCCGGCAATTGAGCACGCTTACGAATCATTTGAAAATTCATACCGGCGAAAAGCCATTCGAATGTGTTATTTGTAAAAAACAATTCCGTCAATCGAGCACACTAAATAATCATATAAAAATTCACATGACCGATAAATTGTATTTAGCGTGTAGTAATAATACATCGGATATTAAAGCCGAAGAGGACGAAGCATGA
Protein Sequence
MSVELVTIYINTLHDPMSRALSRTMTVANGSVDKPFQCNVCERRFRQLSTLTNHVKIHTGEKPYKCSICEKHFRQSSTLTNHLKIHTGEKPFNCTYCGKQFRQLSTLTNHLKIHTGEKPFECVICKKQFRQSSTLNNHIKIHMTDKLYLACSNNTSDIKAEEDEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00203877;
90% Identity
iTF_00203877;
80% Identity
iTF_00203877;