Basic Information

Gene Symbol
Klhl41
Assembly
GCA_951812415.1
Location
OX638313.1:113036831-113071487[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 2.1 8.5e+02 1.1 0.0 30 69 210 251 201 268 0.64
2 8 5.6e-21 2.2e-18 67.3 0.3 8 109 383 484 376 485 0.87
3 8 1.4e-08 5.7e-06 27.4 0.1 53 108 509 564 493 566 0.86
4 8 4.5e-17 1.8e-14 54.8 0.1 6 109 693 790 688 791 0.87
5 8 2.8 1.1e+03 0.7 0.1 77 108 790 821 788 822 0.87
6 8 7.5e-19 3e-16 60.5 0.2 7 109 1097 1198 1093 1199 0.90
7 8 9.6e-21 3.8e-18 66.6 0.4 7 109 1516 1617 1510 1618 0.91
8 8 0.61 2.4e+02 2.8 0.0 85 108 1634 1657 1624 1659 0.87

Sequence Information

Coding Sequence
ATGTTcgatctactgaacttcagcAAGAAAATGCAGGGCTACAAGGTGACCGATAATAAGCGTTCgcgaaaattcggaattgcagCAAACTCGCTGAAAATGCTAATGGAGAAGGCCGGTCAGAAGTTCAGTATTGAAAGCTGCTGTCTCTACCTGGCAAAGGACGGATCCAAGATTACAGACGAAGAATATTTTGCAACTATAGAGCCGCAAACGTTGTTTGTGGTAGTACCGGTCGATGTAAATGAAATTGTAACTGAATTTGATGTCACAATGAATTGCATTCGTGAGAATATCGGTTTGGAAAATTTAAATCACGACTACATTCTGCAAACTTTGATGTCCGACTATCCCGAAAAGTTCAGCGAAGCAATCGCAAACTATCAAAAAACAATTCATCATCGGAAATCTGAAACGGACTTAAGTCTAAAAACCGAACACGCAGAATGGTTTCAGGGTCAGGATCAATGCTTCAATACAAAAGAGGAAGCTATGGCAAAACGCGCACAAGATCGAATCCGAGGCTACTACTACAAAACCAAAGAGGAAATTACAAAATGCGATCTCTACAAAACGAACAGCCAGGCGAAGATCGTCTTCGATCGAATCTTGGAAATATTTCGATATCTGCTGATCGGTTGCAATTATTTTTCGATGATGTTCGATCGAAAGTGCAAGCGAAAACATTCGAGCTTAGCCGATCAGACCGATGCGGGCTCATTGCCTAGTAAAAAGCTGCGACAAATGATTAAAGAGTACACGAGCCGAACCGAAATGCTGGACGATTGGTCGGTCTCGTTGTGTAACGATCGCGGCGATTTCTTTTGCCAGGGCGTCTACAATAGCACGGGAATGTGCAATAAAGGTCACACCATTAATCCGTACGTTTGTCGCGAAAACTTACTTGTCTTCCAGGTATGGAATTTAGATCATCAAATCGAAATTACCAGGAAAGTTTTACCGTCTCTGATCGAAAATGTTCGAAGCTTAGTCGAACAGCCGAATCAAAAATGCCCAATACACGGACGGACGGTAAAAGATGTCAATATTATCGAGTACTTTCTGGAATTGTTTAGCGTGAAGAACTTGAAATTGGTTTACATCGTTTGTCATAACAAGGGACAGCGCGACAATAAATCGAACGGACGATTGCTTTGTGATATTAAACTTTGTGTAGGAGATCATCAAATCGATTGTCACAAATGTGTACTTTCTTCAGCCAGTCCGCATTTCAATGGTCTCTTTGATGatgCTTCTCTAGATAGCGGGAAAGATGTTATCGATCTCACAGACAAAACAAATTTCTCAGTACTGGAAGCTATCATCGATTACATGTACTCGGGTTCGATTTCGTTTGCATTAGTTGAAGAAACCGCAGTGCTTTTTAAAACTCTGGACTACTTCAAAATGAAATCTATGAAAGAGCAATGTGAGACTTTTCTATTGAATAGTATCAATGAACAGAATTGTTTGGCTATGCTTGGCGTGTCGGatgCTTCTCTAGATAGTGGGAAAGATGTTATCGATCTCACCgacaaaacaaatttatcaGTACTGGAAGCAATCATCGATTACATGTACTCGGGTTCGATTTCGTTTGCATTAGTTGAAGAAGCCGCAGTGCTTTTAAAAACTCTGGACTACTTCAAAATGAAACCTATGAAAGAGAAATGCGAGACTTTTCtaatggataatataaatgaagagAATTTTTTGGCTATGCTTGGCGTGTcggTGGGTGATACTAAATCCTGTTACAAGTTCGACATATACGACAAACTGCTTACAACGCTGGAAACTCGACCGCCGTTTTGTGCCTGGGCAATTGCAAAATATAAACACTCTATTTATGCTTTCGAGAAAGCAATTAATCCCGAATGTGAAACTATCGGTTTAAAGTATAATACGATCGAAAATAGTTGGACTCAATTTGGAACCAACAGCCGGGCACTAACAAAACCCGTTCCGATTAACTCTACCGGGATGTGTGCAAaagatgaaaaattatttttgATTCGTCAATCTATGTATTGGGACAAACTAACAATTTTGAGAAATGTATTGAGCGATATGATGACCGCGAAGTTCTGTGATATCAAAATTATTGTGGGAGATTTCGAAATTGATGCTCACAAGGTTGTTCTTTCGGCGTGCAGTCCGTTTTTTAGTCGTAATTTTAAAGATTTTCCGGGTAACGAAATCGATCTATCAGAAATTCATAGTTTTCCAGTTGTATCGGCAATTATCGATTATATGTACTCgggttcgattttatttttatttgaagatGCGAGTCTGATTCTGAAAAGTCTTGGCAGTCTGAAAATGAGATATATGAAGGAATTGGTCGTTAATTACTTTATAAATAATATCGATAAAGATAATTGCATTGCGTTCCTCAAGTTGGCAGaagaattacaaaataaaaggcTGAAAGAAGCTACGCTTCACTTCATAGCCAAGAATTTTCACACAATGCACCTTACAGATGACTTCAATGAGCTTACCTGTACTCAGTTAAAAGCAATTCTGCTGATGATTGCTCCGTTTAATGCCAAACTTGCGTTTGAAGCTATCCTAAATTGGATCAAACACGAACCATCAAAACGTAAATTTTATGTTAACGAACTTTTGGAAATCGTACCGATAGAAAACTTTTCTGTTTCTTATTGTCGCAACTTCATTCTAAATGATGACTTCGTAAAAAACGATTCGAACGGTCGTAAATGGCTGGTTAATTCATTTCTCAGCTTTAATTCGCCGCTGATGCGTTCAAATCAATCATTGTATATTTTCTCGAAGATAATTGATTTATGTTACAAATTCGACGTATGTGATAAATTGCTAACGGAGCTGGAAAGTCGACCACTATTCAATGCCTATGTAATGACTAAATGTGGAAATGATGTTTATACTTTCGGAACAAGAAACGATCTTGTCACAGCTGGAACAAGCTGTTTAAAATACAGCACGATAGAGAACAATTGGACTCACTTAAAAACATTGTGGAAAGGTAGAAACGAAATCTTGGCCTGTGGAATTTGTACAAAGGATAATAAAATCTATTTGATTGGTGGCAAAGCTATTCAAACCCATAACTCTTGTGTATGTTATGATGTTGCGGCAGATCGTTATGCAGCTTTGCCGAATATGGCAATAGAGAGATGTAATCCCGGAGTAGTTTCATATAAGTCTTCAATTTACGTACTTGGTGGCTATCCAGCGTCAGCTTGCATTGTTGAACGATACGATGACAGAGAAGGGAAGTGGTTTCGAGTGGGTGAAACACAACCACAATTCTTTGATATCAAGCTTTGTATAGGAGATAAAGAAATAGATTCACACAAAACCGTACTTGCGGCGTTCAGTCCGTATTTCAGCGATCATTTTGACGATGATTTCTTAAAAAGCGGAGAAGATAGAATCGATCTCAAAGTCAATACTAATATGGCAGTGCTTGCATCAGTCCTGGATTATATGTACTCGGGCTCAATTTCCTTCCTAATTGAAGATGGTGCGATGCTTATGAGAACTCTGGACTTTTTTAAAATGCAATCGGTGAAAGATCTATGCGTGGCGTACCTCGTGGATAACATCGATGCAGAGAACTACGTTGCTGTCTTCAACTTGGGAgAGGAAGTACCTCTCGAAAGATTAAAAGAGGCGGCGGTGGACTACATCaataagaattttgaaaaaattcatgGTTCGGATGAAATCAAGAATCTTTCCAAAGATCAGttagAATCTGTTATACAAAAGACTCGCGATGAATATGCCGAAATAACGTATCAGTCTGTCGTAGGATGGATCAAGCACGACACACCAAATCGTAAAGATTATGTCGAACAGCTACTGAAATatgtttcgataaaaaatttaactgcttcatattattggaaaaatattcgaaaagagGAATTTTTAAAGAACGATGCTGCTGGCCGTCAGTGGCTTTTGGATTCTTTTTTGGACCACCCAGAATCACCGCTTATCAAACCGTCATATCAAACATTGCATATCTTCTCAAACTCGGACAATTCGAATCATGAATTGGACGTTCGCAATAAATCGCTCGCAACGCTTGAATCTCGTCCGGAATTGAATTGCTATGCAATGGTAAAACATGACAGGTCAATTTATGCTTTCGGCAAAAGAAAGGAAAATGATATTGGAAATATTGGATTAAAGTACGACACGACAGCTAACGAATGGACACGATTTGTTGCCAGCTACATTTTCATAAACCCTTCGCCTGGAATTTGTAGTAATGGTGATGCAATCTATTTCGTAGGCGGCTTAGCATTTCATCAaggacaaaaaatttgtttacgttATGATGTGGCGACAAGCCAGTGGAAAACTTTGCCAGACATGAAACATGCTAGGTCGAGCCCCGGTGTTGTTTCGTACAatcagTCAATTTATGTATTTGGTGGCTATTCATCTCCAGTTGTACATAATATCAAAGACGTAGGTACTACCCTTGTTGAACGGTATGATCATAGAGAAGGAAAATGGTTTGAACAAAGTCGTATTAATTTACAATTATCGTTCTTTGATATCAAGCTTTGTGTAGGAGATAAAGAAATAGATTCACACAAAGCCGTGCTTGCTGCGTTCAGTCCGTATTTCAGCGATTATTTTGATGATGCTTTTCTAAATAGCGGACAAGATAGAATCGATCTCTCGGACAATACTAATATGGCAGTGCTGACATCAATCCTGGATTACATGTACTCGGGTTCAATTTCCTTCCTAATCGAAGATGGTGCTATGCTTATGAGAACTCTAGACTTTTTTAAAATGCAATCCGTAAAAGATATATGCGAGACGAGCCTTGTGAATAACATCGATACGGAGAATTACGTTGATTTCTTCAATTTGGCagATGGTGCTATGCTTATGAGAACTCTGGACCTTTTTAAAATGCGATCCGTAAAAGATCTATGCGAAGCGTACATCGTGGATAACGTCGATGCAGAGAACTTCGTTGCTGTCTTCAACTTGGGAgAGGAAGTATCACTCGAAAGTTTAAAAGAGGCAGCGGTGGACTACATCACTACTAATTTTCGAGAGATATATGGTTCGGATGAAATCAAGAAACTTACTAAAGATCAGttagaATCTGTTGTACAGAAGACTTGCGAAGAAGATGCCGAGATAACGTGTGAGGCTATCATAAGATGGATCAAGTACGACACACTCAACCGTAAAGATTATGTCGAACAGCTACTGAAATATGTTTCAATAAAACATATACCTGCTTCATATTATTGGGAATATATTGGGAAAGAGGATTTTTTAAAGAACGATGTTGGCGGCCGTCGGTGGCTTGTGAGTTCTTTTTTGGACCTAGAATCACCACTTCGGCAATATCAAACGTTACACATCTCAACCTCAGATAATTCGTATTATAAATGGGACGTTCGTGAGAAATTGCTTACAACACTTGAATCTCCTCCAAAATTGAATGGCTGTGCAATGGTAAAATATCACGACTCAATTTATGCTTTCGGCGAAGGAGATGAAAATGAAATTGGAGGTATTGGATTAAAGTACGACACGACAACTAAATGGACTCGAGTTGTTGCCGGCAACATTTTGATAAAGCATTCGCCTGGAATTTGTAGTCATGGTGATGGAATCTATTTGATAGGTGGTGAAGAAAATAATCAGCGACAAAGAACTTGTATACGTTATGATGTGGAGACAAGCCAGTGGACAACTTTACCTGAGATGCAAATTCCTAGGTCGAGCCCCGGTGTTGTTTTTTGCAATTCGTCAATTTACGTTTTTGGGGGCTATAAAAACAAGTTGCCCAATAGAATGACTGAAGGACTTACCCGTGTTGAACGCTATGATCCTAGAGAAGGAAAATGGTTTGAACAAAGTTATGTTAAGTTAGAATCGTCGATCAGTTCGGCAGTAGTTTCCGAATACAATGTTTGTTGCTTGCAGTGTAATTCGGATAACGTAATTAATTTCGATACGCGGTCTTCCGATGACACTAATGTGACTTCAAAcgtGGGAACCTCGCTTGCATCACTAGATGGACGACTTTATATAGCCCATGAAGAAGGAATCGCAGAATATAATCCTTACGCAATGAAATGGAatgaaatattacaaaaatctTTGAACTGCCCCTTTTTGATTGCATAA
Protein Sequence
MFDLLNFSKKMQGYKVTDNKRSRKFGIAANSLKMLMEKAGQKFSIESCCLYLAKDGSKITDEEYFATIEPQTLFVVVPVDVNEIVTEFDVTMNCIRENIGLENLNHDYILQTLMSDYPEKFSEAIANYQKTIHHRKSETDLSLKTEHAEWFQGQDQCFNTKEEAMAKRAQDRIRGYYYKTKEEITKCDLYKTNSQAKIVFDRILEIFRYLLIGCNYFSMMFDRKCKRKHSSLADQTDAGSLPSKKLRQMIKEYTSRTEMLDDWSVSLCNDRGDFFCQGVYNSTGMCNKGHTINPYVCRENLLVFQVWNLDHQIEITRKVLPSLIENVRSLVEQPNQKCPIHGRTVKDVNIIEYFLELFSVKNLKLVYIVCHNKGQRDNKSNGRLLCDIKLCVGDHQIDCHKCVLSSASPHFNGLFDDASLDSGKDVIDLTDKTNFSVLEAIIDYMYSGSISFALVEETAVLFKTLDYFKMKSMKEQCETFLLNSINEQNCLAMLGVSDASLDSGKDVIDLTDKTNLSVLEAIIDYMYSGSISFALVEEAAVLLKTLDYFKMKPMKEKCETFLMDNINEENFLAMLGVSVGDTKSCYKFDIYDKLLTTLETRPPFCAWAIAKYKHSIYAFEKAINPECETIGLKYNTIENSWTQFGTNSRALTKPVPINSTGMCAKDEKLFLIRQSMYWDKLTILRNVLSDMMTAKFCDIKIIVGDFEIDAHKVVLSACSPFFSRNFKDFPGNEIDLSEIHSFPVVSAIIDYMYSGSILFLFEDASLILKSLGSLKMRYMKELVVNYFINNIDKDNCIAFLKLAEELQNKRLKEATLHFIAKNFHTMHLTDDFNELTCTQLKAILLMIAPFNAKLAFEAILNWIKHEPSKRKFYVNELLEIVPIENFSVSYCRNFILNDDFVKNDSNGRKWLVNSFLSFNSPLMRSNQSLYIFSKIIDLCYKFDVCDKLLTELESRPLFNAYVMTKCGNDVYTFGTRNDLVTAGTSCLKYSTIENNWTHLKTLWKGRNEILACGICTKDNKIYLIGGKAIQTHNSCVCYDVAADRYAALPNMAIERCNPGVVSYKSSIYVLGGYPASACIVERYDDREGKWFRVGETQPQFFDIKLCIGDKEIDSHKTVLAAFSPYFSDHFDDDFLKSGEDRIDLKVNTNMAVLASVLDYMYSGSISFLIEDGAMLMRTLDFFKMQSVKDLCVAYLVDNIDAENYVAVFNLGEEVPLERLKEAAVDYINKNFEKIHGSDEIKNLSKDQLESVIQKTRDEYAEITYQSVVGWIKHDTPNRKDYVEQLLKYVSIKNLTASYYWKNIRKEEFLKNDAAGRQWLLDSFLDHPESPLIKPSYQTLHIFSNSDNSNHELDVRNKSLATLESRPELNCYAMVKHDRSIYAFGKRKENDIGNIGLKYDTTANEWTRFVASYIFINPSPGICSNGDAIYFVGGLAFHQGQKICLRYDVATSQWKTLPDMKHARSSPGVVSYNQSIYVFGGYSSPVVHNIKDVGTTLVERYDHREGKWFEQSRINLQLSFFDIKLCVGDKEIDSHKAVLAAFSPYFSDYFDDAFLNSGQDRIDLSDNTNMAVLTSILDYMYSGSISFLIEDGAMLMRTLDFFKMQSVKDICETSLVNNIDTENYVDFFNLADGAMLMRTLDLFKMRSVKDLCEAYIVDNVDAENFVAVFNLGEEVSLESLKEAAVDYITTNFREIYGSDEIKKLTKDQLESVVQKTCEEDAEITCEAIIRWIKYDTLNRKDYVEQLLKYVSIKHIPASYYWEYIGKEDFLKNDVGGRRWLVSSFLDLESPLRQYQTLHISTSDNSYYKWDVREKLLTTLESPPKLNGCAMVKYHDSIYAFGEGDENEIGGIGLKYDTTTKWTRVVAGNILIKHSPGICSHGDGIYLIGGEENNQRQRTCIRYDVETSQWTTLPEMQIPRSSPGVVFCNSSIYVFGGYKNKLPNRMTEGLTRVERYDPREGKWFEQSYVKLESSISSAVVSEYNVCCLQCNSDNVINFDTRSSDDTNVTSNVGTSLASLDGRLYIAHEEGIAEYNPYAMKWNEILQKSLNCPFLIA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-