Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0021 13 7.2 0.1 21 45 75 99 68 104 0.87

2 7 0.14 8.7e+02 1.4 0.0 26 51 126 151 120 154 0.88

3 7 0.045 2.8e+02 3.0 0.2 27 48 159 179 152 185 0.83

4 7 9.2e-05 0.57 11.6 0.1 20 43 208 231 201 235 0.84

5 7 0.009 56 5.2 0.1 13 45 229 261 226 264 0.90

6 7 0.12 7.6e+02 1.6 0.3 22 45 266 289 263 292 0.88

7 7 8.1e-06 0.051 15.0 0.1 21 45 293 317 290 322 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0021	13	7.2	0.1	21	45	75	99	68	104	0.87
2	7	0.14	8.7e+02	1.4	0.0	26	51	126	151	120	154	0.88
3	7	0.045	2.8e+02	3.0	0.2	27	48	159	179	152	185	0.83
4	7	9.2e-05	0.57	11.6	0.1	20	43	208	231	201	235	0.84
5	7	0.009	56	5.2	0.1	13	45	229	261	226	264	0.90
6	7	0.12	7.6e+02	1.6	0.3	22	45	266	289	263	292	0.88
7	7	8.1e-06	0.051	15.0	0.1	21	45	293	317	290	322	0.86

Coding Sequence: ATGGCCAAAAAGGGACGAATCAAACTCGACGACGGACCGATTGAAAGCGACAACAATATCAGCAATGTGATATTAATCGAAGATAGTCTCGATAGTGTTATCGACGTCGACTTGCTTGACCTCAAGCATGAACCTTTTTACGGCGATTCACGATGTCCAAAATGTGGACAAAAATTCGAAACGAACGACGAACTTATCACGCATACTGAAACGTCCGAGTGTTCGGAAATCGAATCGATTTGCCATATCTGTATGAAAGTCATTGCAGGacataataatttattgaatCACATAAAAACTCACGAACTGACCGATGACGAACCGATCGAAGTCAAGGACGAAAGTACATTGCCGGAAGATGACGATGATGAAATGAAATGTCCTTTTTGTGGTGAAGGCGTCGGAGACGGCATGGACTACGAAAAACATCTTCATATTCACGCATTTGCCGATTCGTCAGGTACACGATTTCCATGTCTAATTTGCggaaaagaatttaaaactcGAGGCGATCTACGCCGCCATATGTTACGTCACGCCAACATAAAACCATACAAATGTGTCTATTGTCGTAAAGGTTTTGTGACGAAAAACGAACTTCAAACTCATGTACGTTCTCATACTGGCGAACATCCGTTCGTATGTGATATTTGTTATGCCAGCTTTACAACGTCCAGTTCGATGAAGAAACATCGAAGTAAGCATACGGGCGAAACACGATATGTTTGCTATATCTGTTCGAAAAAGTATTTCGATTCGTACGCACTAAATCGACATATTATGATGCATACGGGCGAACGACCATACCACTGTACTGTTTGCAATCGGGGTTTTTGTCAACGAGGCGATATGCGGGTTCATATGCGGATACATACTGGTGAGCGACCGTTCGAATGTCCTATATGTTTCGTAACATTTAAACAGTCGAGCAATAGAAATGCGCATTTTAAAAGGCACGCGAGCCAAATGTAG
Protein Sequence: MAKKGRIKLDDGPIESDNNISNVILIEDSLDSVIDVDLLDLKHEPFYGDSRCPKCGQKFETNDELITHTETSECSEIESICHICMKVIAGHNNLLNHIKTHELTDDEPIEVKDESTLPEDDDDEMKCPFCGEGVGDGMDYEKHLHIHAFADSSGTRFPCLICGKEFKTRGDLRRHMLRHANIKPYKCVYCRKGFVTKNELQTHVRSHTGEHPFVCDICYASFTTSSSMKKHRSKHTGETRYVCYICSKKYFDSYALNRHIMMHTGERPYHCTVCNRGFCQRGDMRVHMRIHTGERPFECPICFVTFKQSSNRNAHFKRHASQM

Sequence clustering based on sequence similarity using MMseqs2