Bcha030523.1
Basic Information
- Insect
- Beris chalybata
- Gene Symbol
- gsb-n
- Assembly
- GCA_949128065.1
- Location
- OX421897.1:9104302-9118124[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 4.9e-72 1.2e-68 230.0 1.0 1 125 22 143 22 143 0.99
Sequence Information
- Coding Sequence
- ATGGATATGTCCGGGACGAATTCGCTGAACATGCGACCGCTTTTCGGGGGATATCCCTTCCAAGGACAAGGTCGCGTCAATCAGCTTGGCGGCGTCTTCATCAACGGCCGGCCGCTACCTAATCACATCCGATTGAAAATTGTCGAAATGGCCGGATCTGGTATTCGGCCGTGCGTAATCAGTCGACAGTTGCGCGTCTCGCACGGATGCGTCTCGAAAATTTTGAATCGATACCAGGAGACGGGATCAATTAGGCCGGGCGTTATTGGCGGATCGAAACCGAAGGTTGCAACGCCCGAAATTGAAAATCGTATCGAGGACCTGAAGAAACAAAATCCCGGCATATTCAGTTGGGAGATACGCGAGAAATTGATCAAGGAGGGAATCACCGATCCACCGTCAACATCGTCGATAAGTCGACTGCTCCGGGGCTCAGAACGTCGAGATGACGATACCAGAAAGGATTACAGTATTCATGGAATTTTAGGCGGTAAGTCGACTTAA
- Protein Sequence
- MDMSGTNSLNMRPLFGGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAGSGIRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVATPEIENRIEDLKKQNPGIFSWEIREKLIKEGITDPPSTSSISRLLRGSERRDDDTRKDYSIHGILGGKST
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00203489; iTF_01160423; iTF_01224201; iTF_00363197; iTF_00345036; iTF_01461102; iTF_00628246; iTF_00999538; iTF_00402710; iTF_00160640;
- 90% Identity
- iTF_00285380;
- 80% Identity
- iTF_00203489;