Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.16 1.8e+02 2.0 0.0 24 44 120 140 112 146 0.83

2 6 0.013 15 5.4 0.0 22 47 146 171 142 176 0.87

3 6 0.12 1.3e+02 2.4 0.0 22 44 174 196 172 200 0.86

4 6 0.064 73 3.2 0.0 22 46 202 226 197 234 0.86

5 6 0.072 81 3.1 0.0 26 45 234 253 231 258 0.88

6 6 0.00067 0.76 9.6 0.0 18 44 254 280 252 287 0.86

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.16	1.8e+02	2.0	24	44	120	140	112	146	0.83
2	6	0.013	15	5.4	22	47	146	171	142	176	0.87
3	6	0.12	1.3e+02	2.4	22	44	174	196	172	200	0.86
4	6	0.064	73	3.2	22	46	202	226	197	234	0.86
5	6	0.072	81	3.1	26	45	234	253	231	258	0.88
6	6	0.00067	0.76	9.6	18	44	254	280	252	287	0.86

Coding Sequence: ATGGAAACTATCGATCCAAACCAGAACGGAATCATTGTCGTAGAAAATTCAACAGGAGAAGAGCTTAATGTCCTAACGATGAGTGAATTACAGCCAGTCGCCAGAACGGTTGTCATTGAAACTACTAATGTGGCTGAAGAAACCCCAAACCATCGAATCATTAAGCTTGAAAGAACTGATAAAGAATGCCAGACTGATCCTGATTTATATTTGAACATGATGGCAAAGAAGATGGATATTGCAATGCGAAATCCTTCTTTAGAGCAGGGAGGTCCTATGAACGGGAAGAATAATGAAACCTACAACTATGCATTGTGGAATGCAGCTCAGCAGCACTATAATCAACAGTTGAACAAGAGGTTTGCGTGCACTCTTTGTGATAAAACATTCACGCAACAAGGGAATTTGAAGACCCACATGATGTCTCATTATTGTGAGAGAAATTTCAGTTGTCCATACTGCGAGAAAACTTTTGTGCAGAAAGGCAACTTAAAAACGCACATCATGCTCCACACGAAAGAAAAAGTGCATGCCTGTCAATTTTGTGACAAAGTGTTTGTTCAAAAAGGTAATCTACAAAGCCACATCCTCACTCAtacgaaagagaaaaaatttcactgtttaATCTGTACCAAGTCATTCACGCAGAAAGGCAATttgaaaactcattttcaaattcacaCTGGTGTGAAAAGGTTTCAGTGCCCCTATTGTGAAAAAGCTTTCAGCCAAAAGGGTAATTTGAAAACCCATGTTGCCAGGCACACtggtgagaaaaaatttcagtgtCCGATTTGTGATAAAATGTTTgtacagaaaaataatttagataAACATATGATGAACCATTCAATTCACAAAAATATTGATGAGCAGTTCAATAGGAGTTGGCAGCAGCCACCTCTGCCCCACCAGCCCCTCCAGCCCCCACAGCACCCCCAGCCCCTCATAGTCGTTAGCCAACCAAATCCAATGGAAATTCCCAAATCTGAGCCTACAAGTGTAGACACGTTTTACAGTTATGTTGGTAAATTATACAACCCTAATCCACAAATACACATGGGTAATTAA
Protein Sequence: METIDPNQNGIIVVENSTGEELNVLTMSELQPVARTVVIETTNVAEETPNHRIIKLERTDKECQTDPDLYLNMMAKKMDIAMRNPSLEQGGPMNGKNNETYNYALWNAAQQHYNQQLNKRFACTLCDKTFTQQGNLKTHMMSHYCERNFSCPYCEKTFVQKGNLKTHIMLHTKEKVHACQFCDKVFVQKGNLQSHILTHTKEKKFHCLICTKSFTQKGNLKTHFQIHTGVKRFQCPYCEKAFSQKGNLKTHVARHTGEKKFQCPICDKMFVQKNNLDKHMMNHSIHKNIDEQFNRSWQQPPLPHQPLQPPQHPQPLIVVSQPNPMEIPKSEPTSVDTFYSYVGKLYNPNPQIHMGN

Sequence clustering based on sequence similarity using MMseqs2