Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.023 26 4.6 0.1 26 44 28 46 16 54 0.87

2 8 0.3 3.4e+02 1.1 0.0 22 45 52 75 48 78 0.85

3 8 0.0023 2.6 7.9 0.1 22 46 80 104 77 112 0.87

4 8 0.27 3e+02 1.2 0.0 26 47 112 133 106 138 0.87

5 8 0.1 1.2e+02 2.6 0.0 27 47 143 163 138 168 0.87

6 8 0.021 24 4.8 0.0 23 47 167 191 163 196 0.86

7 8 2.6e-05 0.03 14.1 0.1 22 47 194 219 191 225 0.86

8 8 1.1 1.2e+03 -0.7 0.0 26 44 227 245 221 248 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.023	26	4.6	0.1	26	44	28	46	16	54	0.87
2	8	0.3	3.4e+02	1.1	0.0	22	45	52	75	48	78	0.85
3	8	0.0023	2.6	7.9	0.1	22	46	80	104	77	112	0.87
4	8	0.27	3e+02	1.2	0.0	26	47	112	133	106	138	0.87
5	8	0.1	1.2e+02	2.6	0.0	27	47	143	163	138	168	0.87
6	8	0.021	24	4.8	0.0	23	47	167	191	163	196	0.86
7	8	2.6e-05	0.03	14.1	0.1	22	47	194	219	191	225	0.86
8	8	1.1	1.2e+03	-0.7	0.0	26	44	227	245	221	248	0.90

Coding Sequence: ATGGCTAAGCCACTGTCCTTTCTTGAATCCCTCAATGATGTAAGGAAGTCCACCTGCCATGCTGGAGACTCAAAAAAATATGCCTGTCATGTAtgcaataaaacattttcacAAAGTTATAATTTAAAAAGTCATGCTGTGATtcacacgggggaaaaaaattacgccTGCGatttttgtggtaaaaaattttaccagaattcaaatttgaagacaCATATGGCAATCCACACAGGTGAGCGCAAGTACAcctgtcaattttgcaacaagaGCTTCACCCAGAGCTCTAACCTTAAAACGCACATCGCCATACATACAGGGCAGAAAAAGTATGTCTGCAGTTATTGTAACAAAGGTTTCGTTCAACACTCCAATTACAAAACTCACTTGGAGATTCATTCCAGCGTTCGCGTTCGAAATTTCCCATGCGCATACTGTGATAAATCCTTCACGCAAAAATCTAATCTCAAGTCTCATTTAGCCTTGCACACAGGTGAGAAAAAGTTCAAGTGCACATTATGTGAGAAGTCTTTTGCTCAACAGTCCAACCTGAAATGTCACATGGAAATTCACAGTGGTGAAAAAAAGTACAAGTGCCCTATTTGCACTAAACCGTTCACTCAAAGCTCAAATTTAAAGTGCCATTTAAAATTGCATGGTCAACTGCCTGGAAAATTGTCCTGCCAGTATTGTAAATTGGTCATATGGAAGGAAATAGATTTGAAAATGCATTTATTGTCATGTGAAGCCCGCTTAAGTGAACTTCAGTCGAGAGCCAAAGACCTCTCTGTCAATCAACATTTTCTATCCTCCTTCAATTCATCCATATATTccaatcaagttttttttctcaatcatgATGATGGTGCCACTTGTAGTGATGAAGAAACTAACACCACCGATCAAAATCCAGCAGATCCCTTGTCTTGTGGTACCAGTATGGACCAAGATGACAACCTTTGA
Protein Sequence: MAKPLSFLESLNDVRKSTCHAGDSKKYACHVCNKTFSQSYNLKSHAVIHTGEKNYACDFCGKKFYQNSNLKTHMAIHTGERKYTCQFCNKSFTQSSNLKTHIAIHTGQKKYVCSYCNKGFVQHSNYKTHLEIHSSVRVRNFPCAYCDKSFTQKSNLKSHLALHTGEKKFKCTLCEKSFAQQSNLKCHMEIHSGEKKYKCPICTKPFTQSSNLKCHLKLHGQLPGKLSCQYCKLVIWKEIDLKMHLLSCEARLSELQSRAKDLSVNQHFLSSFNSSIYSNQVFFLNHDDGATCSDEETNTTDQNPADPLSCGTSMDQDDNL

Sequence clustering based on sequence similarity using MMseqs2