Basic Information

Gene Symbol
-
Assembly
GCA_903994105.1
Location
NW:377-3282[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 2.8e-05 0.0012 18.8 0.2 1 23 223 245 223 245 0.99
2 22 0.11 5 7.4 1.1 5 23 255 273 254 273 0.88
3 22 6.4e-06 0.00029 20.8 3.5 2 23 281 302 280 302 0.97
4 22 0.00014 0.0062 16.6 8.1 1 23 308 330 308 330 0.98
5 22 0.00099 0.044 13.9 4.8 1 23 336 358 336 358 0.95
6 22 0.00033 0.015 15.3 6.4 1 23 364 386 364 386 0.98
7 22 4e-05 0.0018 18.2 4.6 1 23 392 414 392 414 0.99
8 22 0.0023 0.1 12.7 6.0 3 23 422 442 420 442 0.98
9 22 0.00039 0.018 15.1 8.6 1 23 448 470 448 470 0.98
10 22 5.4e-05 0.0024 17.8 5.0 1 23 476 498 476 498 0.98
11 22 0.00039 0.018 15.1 8.6 1 23 504 526 504 526 0.98
12 22 0.027 1.2 9.3 0.4 9 23 529 543 527 543 0.95
13 22 1.1 48 4.3 0.8 14 23 562 571 562 571 0.93
14 22 0.00015 0.0066 16.5 4.7 1 23 577 599 577 599 0.98
15 22 7.3e-06 0.00033 20.6 5.2 1 23 605 627 605 627 0.98
16 22 0.00039 0.018 15.1 8.6 1 23 633 655 633 655 0.98
17 22 4.3e-05 0.0019 18.1 2.5 1 23 661 683 661 683 0.98
18 22 0.046 2.1 8.6 12.0 1 23 689 711 689 711 0.98
19 22 0.00047 0.021 14.9 7.3 1 23 717 739 717 739 0.98
20 22 6e-06 0.00027 20.8 5.0 1 23 745 767 745 767 0.98
21 22 0.11 5.1 7.4 4.6 5 23 777 795 776 795 0.92
22 22 0.66 29 5.0 1.6 1 14 801 814 801 815 0.91

Sequence Information

Coding Sequence
ATGCCGAAGCTAAAAATCCAACTGGAAGAGCACTCTGCACTCAGCACACCCGAGGACTACAATCCAGTGATTCCACCGAACGATAAAAGTGCGAAGGACCCCCTGGGAGACGTCTCGAGGATTGATTGCACGAGCCCTTCAATGCAGGCCCCACCTGACGCGTGCACCAGCCCGGAGTCGAGCGTTATGCCTGGCAACCCATCTTCCCCGTCCGGAGGAAGTCACCCTCAAGATTCCAACAATAGCCGACTTGCATCAGTAGAAGAGACCCAAGACACCTCGCCCTCGTCCATCTTGGATTCGCCCTCCGCTCTTCCCCCCAAAATTGAATGCGAGGATGAAAAAGATTATGCAAGTTGGACTAACCAGCTGCACACAAGCATTGAAATTAAGAGTGAACCCACTCCCCAGACGGATGAGTCAGAACTCAGGTTGGGACGAGGAGGAGAAGAACACGATTTGGAGAATGATATTCGTGATATTGTCCCGACGACAGCGCGAGTGAAAAGAGAGGACATGAGCTCTCCACTTCCCGACCATTCTCATGAAAGTTGGATTGACCTGTCGGATACGAATATCGAAATCAAGAGTGAACCCCCTACCCAAACAAACACGTCGGAATCCGAGTTCGTCGAACATATTCGAACGCAAGCTAGTGAGAACCCATTCACTTGCGGCGAGTGTTCGAGccctttttcttctgaaagcgcTTTAATTACACATATGCAAACGCACGATGGCGAGATACCATTCAATTAcagtcattgctcctcctcATCCAGTATTGAAGATAATTTAAAGAAACACATGCAAACGCATACTGGTAATGAGAAGCTACTTAGTTGCAAtcattgctcctcctctttcagTAGTAAAGACGATTTAAAGAtgcacatgcgaacgcacactggtgagaagccattcagttgcagtcattgcacggcatgcttttctcacaaaaagtctttaacggcacatgttcgcacgcatactggtgagaaaccattcagttgcattcattgctcctcctctttcagttataaaaacaatttaaagatgcacatgcgaacgcacactagtgagaaaccattcagttgcagtcattgcacagCATTCTTTTCCCACAAAAAGTCTTTAACGGAACATGTtcgcacgcatactggtgagaaaccattcaggtGCAATCATTGCTCCTCTTCTTTCAGTAGTAAAGACTATATAAAGGtgcacatgcgaacgcacactggtgagaaaccattcggttgcagtcattgctcctcctctttccgtatgaaaattcatttaaagatgcacatgcgaacgcatactggtgagaaaccattcagttgcagtcattgcacagcatgcttttctcacaaaaagtctTTAACGGAACATGTTCGCACGCATACCGGTGAGACACCATTCAGTTGCAAtcattgctcctcctctttcagtattaaaaacaatttaaagaaGCACATGCAaacgcacactggtgagaaaccattcagttgcagtcattgcacggcatgcttttctcacaaaaagtctTTAACGGAACATGTTCGCACGCATCCTGcatgcttttctcacaaaaagtctTTAACGGAACATGTTCGCACGCATACCGTTGAGAAACCATTCGTTTACAAtcattgctcctcctctttcagTAGTTAAGACAATTTAAAGAtgcacatgcgaacgcacactggtgagaaaccattcagttgcagtcattgcacggcatgctttTCTAACAAAAGGTCTTTAACGGCACATGCTCTCACGCACACTGCtaagaaaccattcagttgtaGTCATTGCTCCTCTTCTTTCAGTAGGAAAGACACTTTAAAGAtgcacatgcgaacgcacactggtgagaaaccattcagttgcagtcattgcacggcatgcttttctcacaaaaagtctttaacggaacatgttcgaacgcatactggtgagaaaccattcagttgcaataattgctcctcctctttcagtattaaaaacaatttaaagatgcacatgcgaacgcacactcgtgagaaaccattcagttgcagtcattgcacggcatgctttTCTCACAAAAGGTGTTTTACGGCACATGTTCGGAAGCATActggtgaaaaaccattcagttgcagtcattgcacggcatgctttGCTCAAAAGCATACTTTAACGGAACATGTTCGCACGCATACTGGttagaaaccattcagttgcagtcattgctcctcttctttcagtaaaaaaggcaatttaaagtcgcacatgcgaacgcacactggtgagaaaccattcagtcgCAGTCATTGCATGGCatgcttttctcacaaaaagtaTTTAACGGCACATGTtcgcacgcatactggtgagaaaccattcagttgcagccATTGCTCCTCTTCTTTCAGTAGAAAGACACTTTAA
Protein Sequence
MPKLKIQLEEHSALSTPEDYNPVIPPNDKSAKDPLGDVSRIDCTSPSMQAPPDACTSPESSVMPGNPSSPSGGSHPQDSNNSRLASVEETQDTSPSSILDSPSALPPKIECEDEKDYASWTNQLHTSIEIKSEPTPQTDESELRLGRGGEEHDLENDIRDIVPTTARVKREDMSSPLPDHSHESWIDLSDTNIEIKSEPPTQTNTSESEFVEHIRTQASENPFTCGECSSPFSSESALITHMQTHDGEIPFNYSHCSSSSSIEDNLKKHMQTHTGNEKLLSCNHCSSSFSSKDDLKMHMRTHTGEKPFSCSHCTACFSHKKSLTAHVRTHTGEKPFSCIHCSSSFSYKNNLKMHMRTHTSEKPFSCSHCTAFFSHKKSLTEHVRTHTGEKPFRCNHCSSSFSSKDYIKVHMRTHTGEKPFGCSHCSSSFRMKIHLKMHMRTHTGEKPFSCSHCTACFSHKKSLTEHVRTHTGETPFSCNHCSSSFSIKNNLKKHMQTHTGEKPFSCSHCTACFSHKKSLTEHVRTHPACFSHKKSLTEHVRTHTVEKPFVYNHCSSSFSS*DNLKMHMRTHTGEKPFSCSHCTACFSNKRSLTAHALTHTAKKPFSCSHCSSSFSRKDTLKMHMRTHTGEKPFSCSHCTACFSHKKSLTEHVRTHTGEKPFSCNNCSSSFSIKNNLKMHMRTHTREKPFSCSHCTACFSHKRCFTAHVRKHTGEKPFSCSHCTACFAQKHTLTEHVRTHTG*KPFSCSHCSSSFSKKGNLKSHMRTHTGEKPFSRSHCMACFSHKKYLTAHVRTHTGEKPFSCSHCSSSFSRKTL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00201894;
90% Identity
-
80% Identity
-