Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.81 1.3e+04 -2.2 0.0 24 48 13 37 6 39 0.78

2 7 0.07 1.1e+03 1.2 0.0 21 43 39 61 30 67 0.85

3 7 0.0092 1.4e+02 4.0 0.5 15 44 90 119 81 123 0.87

4 7 0.00016 2.4 9.7 0.0 20 44 123 147 120 154 0.90

5 7 0.00037 5.8 8.5 0.0 22 52 153 183 148 184 0.87

6 7 1.3e-05 0.2 13.2 0.3 21 51 180 209 178 212 0.89

7 7 0.022 3.4e+02 2.8 0.0 22 30 237 245 229 262 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.81	1.3e+04	-2.2	0.0	24	48	13	37	6	39	0.78
2	7	0.07	1.1e+03	1.2	0.0	21	43	39	61	30	67	0.85
3	7	0.0092	1.4e+02	4.0	0.5	15	44	90	119	81	123	0.87
4	7	0.00016	2.4	9.7	0.0	20	44	123	147	120	154	0.90
5	7	0.00037	5.8	8.5	0.0	22	52	153	183	148	184	0.87
6	7	1.3e-05	0.2	13.2	0.3	21	51	180	209	178	212	0.89
7	7	0.022	3.4e+02	2.8	0.0	22	30	237	245	229	262	0.83

Coding Sequence: ATGGAAAGTCACACGTCAGTGCACACTGGAGAAAGAAAATTCGAATGTAGCGAATGCTGCGCTAGATTTTGCCAGAAGACACTGTTGGAGGAGCACATAAAAGACCAACATATTGATGAAATACCGTTTAAGTGTGACTTAtgccaaaaatttttttccacaatatggAACTTGGAAAGACACAAATTAATACACACTGGAGAGAAAAGATTTGAATGTTACGAATGTCACACTCGATATGCCCATAAGGCAattctaataaaacacatacGTAGTCGACATACTGGTGAAAGGCCATTTAAATGTCAACGCTGTCCGAAGGCCTTTGCTGCCAAGTCGAACTTAAATAGTCATATTAAAACACACCAAGGCCTAAGGCCCTACACATGTGGCATTTGCGAACATCAATTTTCTCAAAAGTCAAATTTAAAGAAGCACATTGCCGGCCATTCCGGAGAAAAGACCATCGAGTGTCCCGTTTGCCATAAAAAGTTTTCAACTAAATATAACTTACAATCTCATATGGAGGTACATAATGGTGAAAAGCCATACTTTTGTGATATTTGTTATGAAAGTTTCAGACACGCGACACAATTGCGAGTACATCGAATGACACATTTTGGCAAACGACCGTACACTTGCACTACGTGCGGAATGAACTTTCTGCACCAGTCTGGCCTAACCGTGCACTCAAAAACGCATTTAGGCGATAAACCTTTCTCGTGTCCTATATGCGGCAAAAAGTTTGTCAAAGAATCTATAGTTGCTAGCCATATGACGCTGCATACGGGAGAAAAACAGTTTGAATGCTTCCTGTGTAGGAAAAGATATGCTGATAAGTCGAAGTTAAATTATCATCTTAAGAAAAAATGTCTTAAAGGTATTAGTATGTCAATACAAGCTCGTTAG
Protein Sequence: MESHTSVHTGERKFECSECCARFCQKTLLEEHIKDQHIDEIPFKCDLCQKFFSTIWNLERHKLIHTGEKRFECYECHTRYAHKAILIKHIRSRHTGERPFKCQRCPKAFAAKSNLNSHIKTHQGLRPYTCGICEHQFSQKSNLKKHIAGHSGEKTIECPVCHKKFSTKYNLQSHMEVHNGEKPYFCDICYESFRHATQLRVHRMTHFGKRPYTCTTCGMNFLHQSGLTVHSKTHLGDKPFSCPICGKKFVKESIVASHMTLHTGEKQFECFLCRKRYADKSKLNYHLKKKCLKGISMSIQAR

Sequence clustering based on sequence similarity using MMseqs2