Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.6e-21 1.8e-18 66.7 0.1 1 56 49 103 49 107 0.95

2 3 1.8e-20 1.3e-17 64.0 0.5 27 81 109 162 104 165 0.94

3 3 5.8 4e+03 -1.7 0.2 14 34 217 237 210 243 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.6e-21	1.8e-18	66.7	0.1	1	56	49	103	49	107	0.95
2	3	1.8e-20	1.3e-17	64.0	0.5	27	81	109	162	104	165	0.94
3	3	5.8	4e+03	-1.7	0.2	14	34	217	237	210	243	0.73

Coding Sequence: ATGGCCCAACATTTGGAATCAAATTTCTCGATTCGCAATTTATTAGTGAAGAATAACGATATCTACCCAGTGTTGACACCACCACCATCTGATGGCTCCATATCACCTAACAACTCGATATCGTCTAGCGAAGAGGAACTTGAAAGTAGGCCCAACTTTACCTACAGTGCGTTGGTGGTAATGGCAATCCGTAACAGTCGCGAGGGCAGACTAACATTGAATGCTATACAGAACTGGATCAGTGATAACTTCCCCTACTATCGGAAAGATGAGCAGGGTTGGCAGAATCAGATAAGGCAGACACTGANNNNNNNNNNNNNNNNNNNNATACAGAACTGGATCAGTGATAACTTCCCCTACTATCGGAAAGATGAGCAGGGTTGGCAGAATCAGATAAGGCAGACACTGAGCACGAACTCGTGCTTCCACAAAATTCCACGACCTATGAACCATGCAGGGCGTGGGAACTATTGGGCTCTGAGTTCGGGATTGCCAGCAGTTGGCTCTGTTGGTGTGGGGAACGGAAATGGGCACGAGGCTTTAGTTAGTGGTGTACGAAATCCTCAGTCACCAAATGAGGTGTATTTCCCTACGCCACAAGAGGTGCATAACCACCAGCAGCAAACACAACTACTGCAGCAGCAGCTGGCAATCCTGCAGCGACAGCAAATTCAACAGCAGCATCAGGAAGTATATCGAAAAATTGCctaccaccaacaacaaatcgcTTTTCCAGCAGCCTATCGAGCGCCAGTTTAA
Protein Sequence: MAQHLESNFSIRNLLVKNNDIYPVLTPPPSDGSISPNNSISSSEEELESRPNFTYSALVVMAIRNSREGRLTLNAIQNWISDNFPYYRKDEQGWQNQIRQTLXXXXXXXIQNWISDNFPYYRKDEQGWQNQIRQTLSTNSCFHKIPRPMNHAGRGNYWALSSGLPAVGSVGVGNGNGHEALVSGVRNPQSPNEVYFPTPQEVHNHQQQTQLLQQQLAILQRQQIQQQHQEVYRKIAYHQQQIAFPAAYRAPV

Sequence clustering based on sequence similarity using MMseqs2