Bros090774.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Bacillus rossius
Gene Symbol
-
Assembly
GCA_032445375.1
Location
CM063655.1:21500994-21513980[+]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 51 0.021 5.7e+02 2.6 0.1 16 28 301 313 300 314 0.90
2 51 0.028 7.5e+02 2.2 0.1 16 28 315 327 312 328 0.90
3 51 0.02 5.5e+02 2.6 0.0 16 28 329 341 327 342 0.90
4 51 0.029 7.8e+02 2.1 0.1 16 28 343 355 342 356 0.90
5 51 0.021 5.7e+02 2.5 0.1 16 28 357 369 356 370 0.90
6 51 0.021 5.5e+02 2.6 0.1 16 28 371 383 370 385 0.90
7 51 0.021 5.6e+02 2.6 0.1 16 28 385 397 384 398 0.90
8 51 0.02 5.4e+02 2.6 0.1 16 28 399 411 396 412 0.90
9 51 0.02 5.4e+02 2.6 0.1 16 28 413 425 410 426 0.90
10 51 0.02 5.4e+02 2.6 0.0 16 28 427 439 425 440 0.90
11 51 0.021 5.6e+02 2.6 0.0 16 28 441 453 440 454 0.90
12 51 0.021 5.6e+02 2.6 0.1 16 28 455 467 454 468 0.90
13 51 0.02 5.4e+02 2.6 0.1 16 28 469 481 466 482 0.90
14 51 0.021 5.6e+02 2.6 0.1 16 28 483 495 482 496 0.90
15 51 0.021 5.6e+02 2.6 0.1 16 28 497 509 496 510 0.90
16 51 0.02 5.4e+02 2.6 0.1 16 28 511 523 510 525 0.90
17 51 0.021 5.6e+02 2.6 0.0 16 28 525 537 524 538 0.90
18 51 0.021 5.6e+02 2.6 0.1 16 28 539 551 538 552 0.90
19 51 0.021 5.6e+02 2.6 0.1 16 28 553 565 552 566 0.90
20 51 0.021 5.6e+02 2.6 0.1 16 28 567 579 566 580 0.90
21 51 0.02 5.5e+02 2.6 0.0 16 28 581 593 579 594 0.90
22 51 0.029 7.8e+02 2.1 0.1 16 28 595 607 594 608 0.90
23 51 0.017 4.7e+02 2.8 0.1 16 28 609 621 606 628 0.91
24 51 0.37 9.9e+03 -1.4 0.0 16 28 623 635 621 636 0.85
25 51 0.021 5.7e+02 2.5 0.1 16 28 637 649 636 650 0.90
26 51 0.021 5.6e+02 2.6 0.0 16 28 651 663 650 664 0.90
27 51 0.021 5.6e+02 2.6 0.1 16 28 665 677 664 678 0.90
28 51 0.021 5.7e+02 2.5 0.1 16 28 679 691 678 692 0.90
29 51 0.021 5.5e+02 2.6 0.1 16 28 693 705 691 706 0.90
30 51 0.029 7.8e+02 2.1 0.1 16 28 707 719 706 720 0.90
31 51 0.021 5.6e+02 2.6 0.1 16 28 721 733 720 734 0.90
32 51 0.021 5.6e+02 2.6 0.1 16 28 735 747 734 748 0.90
33 51 0.029 7.8e+02 2.1 0.1 16 28 749 761 748 762 0.90
34 51 0.02 5.4e+02 2.6 0.0 16 28 763 775 761 776 0.90
35 51 0.028 7.5e+02 2.2 0.0 16 28 777 789 775 790 0.90
36 51 0.021 5.6e+02 2.6 0.1 16 28 791 803 790 804 0.90
37 51 0.021 5.7e+02 2.6 0.1 16 28 805 817 804 818 0.90
38 51 0.02 5.5e+02 2.6 0.1 16 28 819 831 815 832 0.90
39 51 0.021 5.6e+02 2.6 0.1 16 28 833 845 832 846 0.90
40 51 0.029 7.8e+02 2.1 0.1 16 28 847 859 846 860 0.90
41 51 0.021 5.6e+02 2.6 0.1 16 28 861 873 860 874 0.90
42 51 0.021 5.6e+02 2.6 0.1 16 28 875 887 874 888 0.90
43 51 0.028 7.5e+02 2.2 0.0 16 28 889 901 887 902 0.90
44 51 0.021 5.7e+02 2.6 0.1 16 28 903 915 902 916 0.90
45 51 0.02 5.5e+02 2.6 0.0 16 28 917 929 915 930 0.90
46 51 0.021 5.6e+02 2.6 0.1 16 28 931 943 930 944 0.90
47 51 0.021 5.6e+02 2.6 0.0 16 28 945 957 944 958 0.90
48 51 0.02 5.4e+02 2.6 0.1 16 28 959 971 956 972 0.90
49 51 0.02 5.4e+02 2.6 0.1 16 28 973 985 970 986 0.90
50 51 0.021 5.5e+02 2.6 0.1 16 28 987 999 986 1001 0.90
51 51 0.022 5.8e+02 2.5 0.1 16 28 1001 1013 1000 1014 0.90

Sequence Information

Coding Sequence
ATGTTCTCAGAATCGGTAGTAAAATGCCGGCACGCTGGAAGGAAGGAGACTAAAGGCGGCCCCTCCGCTAAATCCTCACGCCTCAATTATCCAGCAGAAAGGAGGATCCTCTCTCTGACGTCATCTCCAACACCCTTCGGGCTGTCCAGACGAGGAGACAACCCTCACCCCTTCCACTGGGCTTCCTCCAACTCTTCCAACCCCCCTTCACCCCTTTTCCACCTCGCAGCCATTACGACAAATGCTCACAGGAGGAGAGTGGAGATGAGGGAAGTGGCATACGTTAAACAGAAGCGGTTATCTGTAATGCCTCAACCAGAACTTCGTTCAGTACGTGCTACAACCGACAGTGGGTCAAGGAAGGGCAGGAGAGTTCACACCACGGCTCCTCTGCCCGCCCCGGAAACGCCACAAACAACACACCCCTTTTTCCGCTGCGCGAAAACCCGGGACTTATCTGCGTTCCCCGGCCTCTCCGCTCTGGCCAAGTTGTCGCCGTTTACTACCCACCCTTACCCTCCTGCCACCACGCGTAAATTTCCCTTCTGGAACAGTTGGGGTGGGAAAGGCTCTTCTGCTCCAGTTGGAATCTCGCCCGCTTCAACCCCTATTCCTTCACTCCCCCCATTTTCCACCCCCGAAGGGGCAGGGGGAGGTTGTTCCCTACTAAAACCTTCCCCTTGTCGCTGCAAGACGGAAGGATCAATGGACGCGTCGGAGCTCGAAGGATTCATGATCCGCGCGCCCGAAGACGAGAAGCGAGGCGCGTGTTCGAGTGGCAATAAAAGCCGAGACGACGTCTTACCGGGCGTCGCTCTGGCGTCCTTTCGATTTCTCGAGCGGCCCCGAGTTAATGCCGAGTTCTCCGGTTTTCCCCAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAACCAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAACCAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAACCAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGTACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAACCAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAACCAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAACCAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAACCAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAACCAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCACCGAGCTGGACTCACAAACAAGGCTCGCGAGCTGAAAGTTCAACGAGCCGGACTTACGAGCCGGGCTCGCTTGTGTAAGACGACGCTTAATGCTTATGCGATATTTACAGCGTCCTTATGGTCGTCCTTTTTCCACGAAAACTACCACCCCTCGAACACACGCGGTGGGAAGAAGAAAGCCTATTGA
Protein Sequence
MFSESVVKCRHAGRKETKGGPSAKSSRLNYPAERRILSLTSSPTPFGLSRRGDNPHPFHWASSNSSNPPSPLFHLAAITTNAHRRRVEMREVAYVKQKRLSVMPQPELRSVRATTDSGSRKGRRVHTTAPLPAPETPQTTHPFFRCAKTRDLSAFPGLSALAKLSPFTTHPYPPATTRKFPFWNSWGGKGSSAPVGISPASTPIPSLPPFSTPEGAGGGCSLLKPSPCRCKTEGSMDASELEGFMIRAPEDEKRGACSSGNKSRDDVLPGVALASFRFLERPRVNAEFSGFPQARELKVHRAGLTNKARELKVHRAGLTTKARELKVHRAGLTNKARELKVHRAGLTTKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTTKARELKVHRAGLTNKARELKVHRAVLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTTKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTTKARELKVHRAGLTNKARELKVHRAGLTTKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTTKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTTKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVHRAGLTNKARELKVQRAGLTSRARLCKTTLNAYAIFTASLWSSFFHENYHPSNTRGGKKKAY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-