Bros082958.1
Basic Information
- Insect
- Bacillus rossius
- Gene Symbol
- PAX6
- Assembly
- GCA_032445375.1
- Location
- CM063652.1:29902237-29922646[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 1e-50 1.1e-46 160.3 0.5 1 92 62 153 62 168 0.96 2 5 3.5e-14 3.7e-10 42.3 0.2 56 92 172 208 167 211 0.93 3 5 3.4e-14 3.6e-10 42.3 0.2 56 92 210 246 208 251 0.92 4 5 6.9e-05 0.74 12.3 0.1 57 92 249 276 246 279 0.81 5 5 2.8e-31 2.9e-27 97.6 0.1 56 117 278 339 276 346 0.96
Sequence Information
- Coding Sequence
- ATGTTGCAGCAGAGCTCCCTCACGACGGCGCCACGGAAGCCCCCGCCGGACCTGTGTGTGTCATGTTCTGTTCTTGCTTGTGCCGCAGAGGACGACCACCTAccgcaccaccaccaccaccaccaccaccaccctccCCCTCAGCACGTAGCCGCTAGCGCGATCTTTGGGTGCTCTGCCGCAGGGCACAGCGGCATCAACCAGCTGGGCGGGGTGTATGTGAACGGCCGGCCGTTGCCGGACAGCACGCGGCAGAAGATCGTGGAGCTGGCTCACTCGGGAGCGCGGCCCTGCGACATCTCGCGCATCCTGCAGGTGTCCAACGGCTGCGTGTCCAAGATCCTGGGCAGGTACTACGAGACGGGGTCGATCAAGCCCCGGGCGATAGGCGGCTCCAAGCCGCGGGTGGCTACCTCCGGCGTGGTCAGCAAGATGGCCGAGTACGAGCGGGAGTGTACACCTGCCCCCGGGCGATTCAGCAAGATGGCCGAGTACGAGCGGGAGTGTACACCTGCGTACTACGAGACGGGGTCTATCAAGCCCCGGGCGATAGGCGGCTCCAAGCCGCGGGTGGCCACCTCCGGCGTGGTCAGCAAGATGGCCGAGTACGAGCGGGAGTGTACACCTGCGTACTACGAGACGGGGTCTATCAAGCCCCGGGCGATAGGCGGCTCCAAGCCGCGGGTGGCCACCTCCGGCGTGGTCAGCAAGATGGCCGAGTACGAGCGGGAGTGTACACCTGCGTACTACGAGACGGGGTCTATCAAGCCTCGGGTGGCCACATCCGGCGTGGTCAGCAAGATAGCCGAGCACAAGCGGGAGTGTACACCTGCGTACTACGAGACGGGGTCGATCAAGCCCCGGGCGATAGGCGGCTCCAAGCCGCGGGTGGCCACCTCCGGCGTGGTCAGCAAGATAGCCGAGTACAAGCGGGAGTGCCCATCGATATTCGCGTGGGAGATCCGAGACCGCCTGCTGTCCGAAGGCGTCTGCACCAACGACAATATTCCTAGCCGAGGACTGCAAATTGTTTCCGTGTCTGgctgcccctcccccctccccctcttgctCGTCAACCCGGAGTGGCTATCAAAGCAACGTCTGTGTACACACAAACCCCCTCACCACCCCTTCCTCAGCGGGCTAATGGGGCCCGTGACATATCTTACAGCGCCCGGGCTCTGGACGGCTACTGTGTACAACCTCTCCATGTCGCGTCGGCGCGGGAGTTtcctcccccccttctctctaCCCACTTGCCTGTGTCAACACAGGGGTCTAAATGGACCTCTTGCCCTCTCGCCCTCCAGAAGCGACTGCCCATGCCCATTCATTGGCATAAACGGCTCCCGTGATAAAGGGAATGGAGACGTGGGGAAAGAGATCCTTACCCTCCTCTCTCCCCCCAAACATTCTCTCCTCAACACTCGAGCCCCCGAACTAAAGGAACTGGAGAGGGGTAGTTTTATTAATGTTGGATATTGGAGAGGGGGTTGGAAGGGTCACGGGGTCACCATCACGACACCTGGGAACCAGCTGCAGGCTAAAAACTCAAGTGAGGAGGAAGGGGGTGGGGTGTGGTCCCAGCGCCGGCGCCGGCGGTGCTGGATTCCTCCAGCCTCcgagacgcgggtccgccattttCTGCTCCGCCACGCGCGCTGTAAACGCCGGCGCCTCGGggtcttccccctcccctccgcgTCGCCCCTTCCCCCTCAATccttcccctcccccacccacgCTCTTCTCATAATCCTCCCTCCCCTCTCCCAGCCGTCCCGAAACCCCCGCATAAGGCGAGGGCGCACGCAGCTCCTGGGTCGCTGGAGTCGGAACAGGATGGAGGAGGGGAATAAGGaggaggaggaggaggaggaggaggaggaggaggaggaggaggaggaaccGGAGGCACGGGAGCGAGGTGTAGCGAGCGTCGGAGCGCGCAGCGGTCGGATCCGCGTTCGCtcgtctgtttgtttgtttgtttgtttaaataattCCGCAGCCCGCCGAGAGCGGCTCATCGACCCGGCGATATCGCCGGCGGCGAAAACTGGCCGCGGCGAGCGTAAACAACGGCCGATCCTTTCTTTCCTCACTTTCCCGACGAGATCATGGACGGGAGAAAATATCATCCTCATATGCCGCTTGGTCCACGTCCCCGTTTCTGCAGTGCGCACCGTCAATGTCCCACACACATCACTTTCCCGCAGTACAGTTCTGCAGATGTGA
- Protein Sequence
- MLQQSSLTTAPRKPPPDLCVSCSVLACAAEDDHLPHHHHHHHHHPPPQHVAASAIFGCSAAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATSGVVSKMAEYERECTPAPGRFSKMAEYERECTPAYYETGSIKPRAIGGSKPRVATSGVVSKMAEYERECTPAYYETGSIKPRAIGGSKPRVATSGVVSKMAEYERECTPAYYETGSIKPRVATSGVVSKIAEHKRECTPAYYETGSIKPRAIGGSKPRVATSGVVSKIAEYKRECPSIFAWEIRDRLLSEGVCTNDNIPSRGLQIVSVSGCPSPLPLLLVNPEWLSKQRLCTHKPPHHPFLSGLMGPVTYLTAPGLWTATVYNLSMSRRRGSFLPPFSLPTCLCQHRGLNGPLALSPSRSDCPCPFIGINGSRDKGNGDVGKEILTLLSPPKHSLLNTRAPELKELERGSFINVGYWRGGWKGHGVTITTPGNQLQAKNSSEEEGGGVWSQRRRRRCWIPPASETRVRHFLLRHARCKRRRLGVFPLPSASPLPPQSFPSPTHALLIILPPLSQPSRNPRIRRGRTQLLGRWSRNRMEEGNKEEEEEEEEEEEEEEEEPEARERGVASVGARSGRIRVRSSVCLFVCLNNSAARRERLIDPAISPAAKTGRGERKQRPILSFLTFPTRSWTGENIILICRLVHVPVSAVRTVNVPHTSLSRSTVLQM
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -