Agaa017359.1
Basic Information
- Insect
- Autographa gamma
- Gene Symbol
- MBD-R2
- Assembly
- GCA_905146925.1
- Location
- LR989851.1:10216123-10224643[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 7.1e-18 3.8e-14 52.6 0.0 5 60 740 799 736 859 0.87 2 2 3.2 1.7e+04 -4.0 0.1 52 75 1111 1133 1109 1134 0.78
Sequence Information
- Coding Sequence
- ATGGCAGTAAAAAAATGTTGTATACACAACTGTAAGTCATGTTCTACAAGAAAAGAAGACAAAGGTGTCACTTTCCACAAATTTCCAAAAGACATTTCATTATGTGGAACTTGGATTACAGTAACACGTACCAAACACACAGCCCTGCTAAAGTATGTCTGCTCGCGACATTTCTGTAAAACCGATTTCGAAATTTACAAGGATTCTAAGTACATGTTGAGATCAGATGCTGTACCTTCCATATTTCCCTGGAACTGTGACTCAGACTCGTCTGACGACTACATGGATTCCTCAATAACGTCAGAAGAAGGGGGTGAAATAGAAAATGTGGACGCAATCAAGAAATTTATTGAAGCACAGGAGAAAGAGATCCAAGATCAGAGATTGGTAGACTTGAAGTCTGGTGACAAGAGTAGTGATGGCACGGACAGTAACAGGCCCAGCCAGGAAGAGACTTCATCTGTGTCTAGTGGTGTCATTGACATGGTAATAAATGAGTCGGAATTGGAAATTTCGAGGAAAGATGATGGGAAATCTAAAGATGAGTTTAGTCCTTCAGACAAAGGATGCGGCAGTATGGCGCTGTCAGTCGGTTCTAAAGTGGAGGCCAAGGATTTCAGTGAAGACTGGCATCCTGCCGAGATTATAGAGGTAGACTATGATGACATGGAGGTGCTCGTACATTATCAACACGACAAAAAGAGACCTGACGAATGGATAAACGTTAGTAGTCCGCGTCTAAGACCACTCAGCTACTCGACAGCTAGTAGTAGTGGCACGACCACTGTCCTACCGGGCCCTAGTTCTGAGGACAGTCTCACGGACTCCCTGCCTATCGCCAGCCTGAGGGAAGACTCTAAAGACCAGAAGGACCAGAAGACGGAAGATAAAGTGAAGCTGACCTTCTTAGTGGGCGAGAGATGCCTCGCTAGGTGGCGCGATAATAGGCGGTTTGTAGCTACTGTACTGAAAAATTTAGGGGAAGGCAAATACGAGATATTATTCGATGATGGGTGCCATTGGACGTGTAATACGTCAAGGCTTTACAAACTGCGGTCTAAGAAAAGCATCGCTTCCGCCGCTCTAGTGTCCCCTAGCCCGTTCGGATCAGGGCCTAGTACAGCAAACCCGCAGTACCCTGCATTCCACACACACTTATTTGACCCTACCCGAGACTATTTAGGCTCAAAAAGTGAAAGGCGTGAAATGAAACGCAAATTAAATATTAAAGAAATATTTAATATAGGACAAAAACGGTCACGGAAGCAGAAGAGCCCAAAGGAGAATACGGTGAAAAGTGTTGAAAAGAAACCTCGAACTATTAAGAAGAGGATAAAGTTGAAACTAAAGAGTGAAGTGAAGTTGGAGCCTAAATCCGAATTACCTGCTGTAGATGCCGTGGCGTCCATCATTGGCACTGTTAACCAAGAGGAACCCGAAACGGTTGAGCCAAAAGGGACTGAGGTTGTAAAACCAGAAGAAATCAAAGTAAACAAGGAAGAGGAAGAAGAAGTAAAAGATATTAGTCTTGATAAAAAGGAGGTTCCTCTCACTGAACCTGAGAAGGATGAAGATCTTATTGAGCTAGAGGATCTCAAAGGTGACTGGAAGGACCCGGTCCTGGAAGAAGAGGTTATACTCGAACAATTCGAGAAGCCAGACGAAGGTACACATGAGGAAGTGATTGATAGAATCAAGGAAGTCATCAACAAATTAGAGGACGGCATCCACCAAGCTGAGAAGATCAACTCGCCTAAAATAGAACCAAAAGAGGAAATAATATCCCCAATAGTACCACTAGCGCCAAAAGAAGAACCCCAGGAAGTCAAAATCGAACTTAAAGAAGTAGAAACAAACACTGACAATACAGAAAAACCCGAAAAAGACAAAACAAAGAAACTATCAAAGGTTAAGAAAGGCAAAAAACTAAAACTCCTCCGAGAAAAGAAAGTCAAAATACAGGTCGAGAAAGTACGTAATGAGTTAGAAATGATGAAGAAGCAAGTGAACGAGATGCGGAAGCAGATGTTGACGAATCAGCGCGGCTATACCAAGCGGTCGCCCGGCGCCGTGCTGCCGGAGAGCTTCATGCTGCCGGGCGAGTGGTGCTGTCGCTGGGTGAACGGCCAGCCGGTGGGCACGGTCAGCGAGATCGAGTGCGACGCCAAGCCGCCGGTCGATGCTTCAGGCAAGCCGCCGCTGCCGAGGAGAAGTGTACAGGTCGAGGACAAAAGACTACCTGAGGGTTGGACAAAGCATATGGTGCGTAGGAGCTTTGGTCACTCCGCGGGCAAATGGGATGTGGTGCTTATCAGCCCTGAAAACCGAAGGTTCCATACCAAGAATGAAGTGCGAACCTACTTAGACAACAACCCAGGTTTGAACCTCGAAGAGTACAGTGCCGCGTTAACAGACTTTGGTGTGCACCTGAAGCTGTCCAGACGGATGGGCTGGATATCCTACACCCCAGACGGTGCGGCCGAAGGTCCCGCGTCTCCGCTACCAGCTGGTACTCTGAGCAGTACCTCCCCACTGGTCAAGCGTAAGAAACTCAGCCTCAGAAAGGAGGTCAAGTCTAAGAAGAAGCCGAAATCAGAGAAGATTAATCTGCCGCGTACTGAGGCCCTGCAAATGGAAAACGTGGTGCCATCCCCAGTCGCTGCAAGTAGTGTAGACGACAGCAGTACGTCAGTGGATACTACTGTTGATGTTCCACCGCTCGAAGATGGATATGTATTTGTGGGGTCGCTGAAAGTGCAAATAATCGATAATCTACTTCGATGTCCTGCGGACAATTGCTTTAAGAATTTCCGAAACAACACCCTTCTACAAATGCACATTAAGCATTATCACCGCGAACTAAAGAAGATGATGGGAGCAACCCCCAAGGTACTCGACCTCGCGTACGCCAGGACCATGCCACTGACAGTGGAAACACCAACCCGCTCCAGGGATGACAAGATCATCAGAGTCAAGATACCGCGGCCACCGAAACGAGAAGAGCCCAAACCAGAAGTTAAAGAAATTGTTAACGAGCTTAAAGTCGATACCAGATTACACTCGCCAGTACGCGAACCTGAGAACATTCCCATTCCAAAGAGCCAGGACTCGCCTAAACTGCGGCAGGCCCTGATCAACAAGCCTGTGAAGAGACCTAAAGTCCTGCTGCCAGTCAGGCGGCCCGACCCAGAACCGGTCGTACCTGACGCTATAATCGAGGACATGGTCTTTGAGAACAAACTGCCTATGGCACCTTCCCCAAGTTTCCCATCTTTACAAGCTCCCTTGGACTTTGAGAGTGCGATATCCACGCACACTGTGACCAAGCCTTTCCTGGATAAAAAGCGGAAAGTTGAAAAGAAGAAGAAGACATTTGCGTTTACACCTAAGATGCCTATGAGTGAGGAGGATGACTGGAGCGGGATCAACTCTGACCTGGACACCAGGTCTAGCTTCCCGCGGTCAGAGACCCCGGACAAGTACGATATAAAACCTGCGATTTTGCAAGAGACTGTCGAAGAACAAAAGCCTCCAAGTAGCCAGTACATGTATAATGAAAATGGTGAGCGTATAAAGCTGGTGCGTATGAAACGCGAGGAGATCATCAACTGCCACTGCGGGTTCCGTGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGTCTGTGCTGGCAGCACGCGCTCTGCCACAACATACAGCGCGAGAGCGAGGTACCGGAGAAGTACACGTGCAGCATCTGCCTGAACCCTCGCCGCGGCCGTCGCTCGATGCGCTTCGTGCACGAGCAGGAGCGCATGCTGGAGGGGCAGCTGGCGGGCGCGCGCCCCTGCGACACGCTGCGCCGGAGCCACGAGCTGGCCGGCAACCTGCTCAGGCTGCAGGACGCTCTGCACGCGCTCCGGGTCAAGACCTATGTCGCCACAAAAAAGGACCATCCAAAGCTGTACCTATGGGCTGAAGACTGGGAGAAGGCGGAGATTCAGTACACACAGGAGAAGCTGAACTCTGACTACTCCGACCTGAACATCGTGATCAACAGTGTTGATAAGGAGAACCTGCCTGTGAAACATGAGGATGTTAAGGACACACTGCCTTCTGAAGACCATGAGCAAGACAGGTACATGCATAGAGATGGCTCCATGGGCACACAGGCCTTACTGAGCAGCCTGATGTCCAGCCCCGGCGCGGAGTCTCTCGACCTTCCTATAAGTACCTCAGAATTGGAGCGACTCGCCAAATCTGTTCAAGAGCAAGAAGCCCAGCGGACAACTATAACCGCCCCGGAGCCAGAGGCGGCGATAGAGAACAGCGTGTGTCGAGAGCGGCTGCTGAAGCATGTGCAACGATGTCAGGCGCTCATAGATGCCAGGCTCGAGTCCATAGAGGCACAGGTTGCAGAGCTAGAATCTCAGAGCCCGTCTTTGGAAGATGACGAGACGGCGGAGTTCTTCCCGCGCACGAAGCAGACCATACAGATGTTGATGCGAGACCTAGAGACTATGGAAGAGCTTGGAGTTATAACCTAA
- Protein Sequence
- MAVKKCCIHNCKSCSTRKEDKGVTFHKFPKDISLCGTWITVTRTKHTALLKYVCSRHFCKTDFEIYKDSKYMLRSDAVPSIFPWNCDSDSSDDYMDSSITSEEGGEIENVDAIKKFIEAQEKEIQDQRLVDLKSGDKSSDGTDSNRPSQEETSSVSSGVIDMVINESELEISRKDDGKSKDEFSPSDKGCGSMALSVGSKVEAKDFSEDWHPAEIIEVDYDDMEVLVHYQHDKKRPDEWINVSSPRLRPLSYSTASSSGTTTVLPGPSSEDSLTDSLPIASLREDSKDQKDQKTEDKVKLTFLVGERCLARWRDNRRFVATVLKNLGEGKYEILFDDGCHWTCNTSRLYKLRSKKSIASAALVSPSPFGSGPSTANPQYPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKRSRKQKSPKENTVKSVEKKPRTIKKRIKLKLKSEVKLEPKSELPAVDAVASIIGTVNQEEPETVEPKGTEVVKPEEIKVNKEEEEEVKDISLDKKEVPLTEPEKDEDLIELEDLKGDWKDPVLEEEVILEQFEKPDEGTHEEVIDRIKEVINKLEDGIHQAEKINSPKIEPKEEIISPIVPLAPKEEPQEVKIELKEVETNTDNTEKPEKDKTKKLSKVKKGKKLKLLREKKVKIQVEKVRNELEMMKKQVNEMRKQMLTNQRGYTKRSPGAVLPESFMLPGEWCCRWVNGQPVGTVSEIECDAKPPVDASGKPPLPRRSVQVEDKRLPEGWTKHMVRRSFGHSAGKWDVVLISPENRRFHTKNEVRTYLDNNPGLNLEEYSAALTDFGVHLKLSRRMGWISYTPDGAAEGPASPLPAGTLSSTSPLVKRKKLSLRKEVKSKKKPKSEKINLPRTEALQMENVVPSPVAASSVDDSSTSVDTTVDVPPLEDGYVFVGSLKVQIIDNLLRCPADNCFKNFRNNTLLQMHIKHYHRELKKMMGATPKVLDLAYARTMPLTVETPTRSRDDKIIRVKIPRPPKREEPKPEVKEIVNELKVDTRLHSPVREPENIPIPKSQDSPKLRQALINKPVKRPKVLLPVRRPDPEPVVPDAIIEDMVFENKLPMAPSPSFPSLQAPLDFESAISTHTVTKPFLDKKRKVEKKKKTFAFTPKMPMSEEDDWSGINSDLDTRSSFPRSETPDKYDIKPAILQETVEEQKPPSSQYMYNENGERIKLVRMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQRESEVPEKYTCSICLNPRRGRRSMRFVHEQERMLEGQLAGARPCDTLRRSHELAGNLLRLQDALHALRVKTYVATKKDHPKLYLWAEDWEKAEIQYTQEKLNSDYSDLNIVINSVDKENLPVKHEDVKDTLPSEDHEQDRYMHRDGSMGTQALLSSLMSSPGAESLDLPISTSELERLAKSVQEQEAQRTTITAPEPEAAIENSVCRERLLKHVQRCQALIDARLESIEAQVAELESQSPSLEDDETAEFFPRTKQTIQMLMRDLETMEELGVIT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00185388;
- 90% Identity
- iTF_00185388;
- 80% Identity
- iTF_00185388;