Basic Information

Gene Symbol
Mbd3
Assembly
GCA_947532105.1
Location
OX383970.1:11881637-11886171[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.9e-28 2.9e-24 85.8 0.0 1 72 5 71 5 75 0.95
2 2 0.0014 5.9 7.9 0.0 29 74 93 146 79 149 0.87

Sequence Information

Coding Sequence
ATGAATATTTCCATTGAGAAGAAGCGTATGGACTGCCCTGCTTTGCCGAAAGGCTGGCAAAGGGAGGAGGTCATGAGAAAAACCGGTCTCTCTGCTGGGAAAGTCGATGTTTATTACTACAGCCCAACAGGTAAAAAGTTTCGCAGTAAGGCAGAGCTAGTTCGTTATCTGGGTGATAGTACGGACCTGTCATGTTTCGACTTTCAACATGGTCAGATAAACACTATGCTGCTCTGTAAGGTGAAGAAGGCACGGGCGCAGTTTGACTACAGGGGTGTTCGCAACGACGCATCTCTGGTCCCTCCGATCCGCCAAACGGCGTCGATATTTAAACAGCCGGTGACGGTTTACAAAACACAGGAGAGTAAGGTCAAAACTGACCTCAAACATGGCACGCAAGAAAAGCCTAAACAGCTGTTTTGGGAAAAAAGGCTTGAGGGCCTGACTGCGTGTGATTCCTTTGGGGAACTAGGCACGACTGCTCTTCCGAAGTACATAAAAACACTCGGCCCGTATACATCAGACGCCACCACTATTCAGTCACTCGCTACAGCATTGCATGTTTCTTCGCAGCCACTTACTGGTCAAACAGGATCAAAACAGGCGATATTGGAGAACCCTGGAGTGTATCTAAACCCGGAGCAGCCTCTGATAGCGGCGGTGACCATCACTAAAGACGACGTGCGGCGACAGGAGGAGCGAGTGAAGCGGGCGCGACTCAGGCTGCAAGAGGCTTTGACGGTCGCGTAG
Protein Sequence
MNISIEKKRMDCPALPKGWQREEVMRKTGLSAGKVDVYYYSPTGKKFRSKAELVRYLGDSTDLSCFDFQHGQINTMLLCKVKKARAQFDYRGVRNDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGLTACDSFGELGTTALPKYIKTLGPYTSDATTIQSLATALHVSSQPLTGQTGSKQAILENPGVYLNPEQPLIAAVTITKDDVRRQEERVKRARLRLQEALTVA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01090793;
90% Identity
iTF_01403451;
80% Identity
-