Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.6e-25 1e-21 77.3 13.2 2 69 38 105 37 106 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.6e-25	1e-21	77.3	13.2	2	69	38	105	37	106	0.96

Coding Sequence: ATGGACAATAAGGGCAACCCACCTCCCGGCTTTATGCCACCACCGGCATACGGCCCTCCACAACCAGGTCAACCCTcTGTGGTGATCGTCCAGGCCCCAGCTTTGGGCCCAGAAACGGCAGCAATGACCTGTCCCCACTGCCGTGCAAATATTTCAACCCGTGTCGAACAATCATCGTCAACTAAGACTCACCTCTTCGCTCTGCTTCTTTGCATACTTGGGTGCTGGCCTTGCGCTCCCTGCCCATACTGTATGGACAGCTGCTTGACCAAGAAGCATTTTTGTCCAGCTTGCAACGCATTCATTGGAGAATACAGCAATTAG
Protein Sequence: MDNKGNPPPGFMPPPAYGPPQPGQPSVVIVQAPALGPETAAMTCPHCRANISTRVEQSSSTKTHLFALLLCILGCWPCAPCPYCMDSCLTKKHFCPACNAFIGEYSN

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00176074; iTF_00175438; iTF_01413826; iTF_01412771; iTF_00060773; iTF_01414631; iTF_01200585; iTF_01411978; iTF_00940047; iTF_00939187; iTF_01303864; iTF_00719050; iTF_00719873; iTF_01049311; iTF_01048564;
90% Identity: iTF_00176074; iTF_00175438;
80% Identity: -