Basic Information

Gene Symbol
-
Assembly
GCA_905333075.2
Location
HG995393.1:9255478-9271436[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.021 3.2 10.2 4.3 1 23 311 334 311 334 0.98
2 10 0.024 3.8 9.9 1.2 3 23 343 363 341 363 0.96
3 10 5.9e-05 0.0091 18.2 0.5 2 23 399 421 398 421 0.96
4 10 1.3e-05 0.002 20.3 1.4 5 23 426 445 425 445 0.96
5 10 4.7e-06 0.00072 21.6 1.8 1 23 451 473 451 473 0.97
6 10 5.7 8.8e+02 2.5 0.4 2 22 483 503 483 507 0.89
7 10 4.3e-05 0.0067 18.6 2.9 1 23 511 534 511 534 0.91
8 10 0.00072 0.11 14.8 1.4 1 23 540 563 540 563 0.95
9 10 9.4e-05 0.015 17.5 4.8 1 23 571 593 571 593 0.97
10 10 0.00018 0.028 16.7 0.2 1 23 599 622 599 622 0.96

Sequence Information

Coding Sequence
ATGCAAGAAACATTAAAGATATGCCTGACATGTCTAAGCACGGATCGCTGCCTTGTTCCTTTGCATAAAATAACAATGCTACTACAAGAAATACATTTCGGAGAGTTGAAAGAGTTTCACGGCGGAGTATGTTGGGAATGCCGAAGTATCCTGGCAAAGATCTATTGGTTTAAGAAAAAAGCTAAAATAGCACAAGAGACGTTATCACAAACTAGAGAGGATTTCAATATAAAACCGCTAACAACATTGACATCAAAAACCAAAGGTTTCTATGATTATCAGTTCACCTATAACTTGGACCCTTTAACAAACTGTAACACAAAATTAAAAGCTGAACCAGaaacaataaaacaagaaaTCATAGACCAAAGCGAAAATATAAACAACACTTCAgattttgatgaaaaaaaaacagatttttatgaAGAAGTAATAATTGTCTATGATAATGTAATAGAAACGAAATACGATgataccttattaaaaaaacaagaagTTAAAGACCATACAGcatatgatgatgataatattatAGACGACACTtcagatttagatgaaaaaaCGTCAGACTTTGATGAAAAATTATCTAACACAcctgaaaaaattgaaaaagtatatGTAGATGTGgttgaaaataaacacaacgataatttgttaagaaaaaaaagatgTTCTCAATATGAAAGTGAAGTTAAAATTAACTTTGCCAAAGTAACTTTTCGTGAAACCAACGAAAAACTTAGTAAATCAACCGAAAATGTTTATGTAAAAACTATTGAAAAAAAACGCAATAAATATTTACGAAACAGAAAAACCAAAAGAGATGTTGAAGAGTTCCAAGAGAAATTTGTACGAGTTGTATTGAGTGAAGAAGAGATGCTTAGACTGAGAGAAGAAAAGAGAAGTCATCACAATTTTAAGAAGCTTCcttataaatgtgatagttgtGTACTCGGGTTCACAAGGAAGGATACTTATTGCTTACATTTGAAGAAGAAGCATGATGAGAGCATTGGTGACCAAATCTGCGAAGTATGCGGCATCCGTTTACGTCACAAACTGGCGTTGAATAACCATAAAAGCAAACACTATGTGGTGTACAGATGTCGACTATGTAAATATGAAGCCCATGAGTTTATGTCTGCTGTCAATCATTGTAAGACCAAACATGCAGCTGACAAGCCTGATAGCATACATTGTTCACAGTGTAACGCAGTCGTCAAAACCCCCGACGATTTACAAAAACACATGCAGACGGAGCATACCCTCTTCTGTGACTGTGGTATTAAATTCAAAGACAAGAACAATCTCAGAAGACATATGAGGCGAGCCCACTCCGTTCTACGTAACTTCATATGTGACATttgcaaaaaaacttttaaaactaaGACGCGGTTAGAAACTCACATGGTAACGCATAGCGGCAATATTGCGAAGAAGCTAGCGTATTGCCAACAGTGCAATGTGcagtataaaaatatacaagTCTACAGGATTCATTTGAAGTCTAGTGCTAATCATTCAGAAGGGTATCCATGTTCAGAGTGCAATAAGAAGTTCAGGTCGAAAGGATATTTGAAGCAACACTATGACTTCTATCATTTACGAAAATCGCAGTATAAATGTGAAATATGCAATAAGCTCTTCATATCAAACTGGCGTTTACGTAATCACAAGCAGCTGTACCATGGGCTGAGTAGACCAAGAAATCATTCGTGCAACACATGTGGCAAGAAATTCTTTACTTCAGCAACGCTCCGCAGCCATCAGTTCACTCATTCAGACCAGCGATCGTTTATGTGTGAAGACTGTGGCGACACTTTTAAGCAAAGTGCAGCCTTGTACACACATACGCGGCTTGTGCACAAAGGTGGAGGGACACGGAAGAAGCGCGATTGA
Protein Sequence
MQETLKICLTCLSTDRCLVPLHKITMLLQEIHFGELKEFHGGVCWECRSILAKIYWFKKKAKIAQETLSQTREDFNIKPLTTLTSKTKGFYDYQFTYNLDPLTNCNTKLKAEPETIKQEIIDQSENINNTSDFDEKKTDFYEEVIIVYDNVIETKYDDTLLKKQEVKDHTAYDDDNIIDDTSDLDEKTSDFDEKLSNTPEKIEKVYVDVVENKHNDNLLRKKRCSQYESEVKINFAKVTFRETNEKLSKSTENVYVKTIEKKRNKYLRNRKTKRDVEEFQEKFVRVVLSEEEMLRLREEKRSHHNFKKLPYKCDSCVLGFTRKDTYCLHLKKKHDESIGDQICEVCGIRLRHKLALNNHKSKHYVVYRCRLCKYEAHEFMSAVNHCKTKHAADKPDSIHCSQCNAVVKTPDDLQKHMQTEHTLFCDCGIKFKDKNNLRRHMRRAHSVLRNFICDICKKTFKTKTRLETHMVTHSGNIAKKLAYCQQCNVQYKNIQVYRIHLKSSANHSEGYPCSECNKKFRSKGYLKQHYDFYHLRKSQYKCEICNKLFISNWRLRNHKQLYHGLSRPRNHSCNTCGKKFFTSATLRSHQFTHSDQRSFMCEDCGDTFKQSAALYTHTRLVHKGGGTRKKRD*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2