Ades006444.1
Basic Information
- Insect
- Aspidiotus destructor
- Gene Symbol
- -
- Assembly
- GCA_035079395.1
- Location
- JAVHKZ010000002.1:57672399-57676355[-]
Transcription Factor Domain
- TF Family
- Homeobox
- Domain
- Homeobox
- PFAM
- PF00046
- TF Group
- Helix-turn-helix
- Description
- This entry represents the homeodomain (HD), a protein domain of approximately 60 residues that usually binds DNA. It is encoded by the homeobox sequence [7, 6, 8], which was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [1, 2], as well as plants [4], fungi [5] and some species of lower eukaryotes. Many members of this group are transcriptional regulators, some of which operate differential genetic programs along the anterior-posterior axis of animal bodies [3]. This domain folds into a globular structure with three α-helices connected by two short loops that harbour a hydrophobic core. The second and third form a helix-turn-helix (HTH) motif, which make intimate contacts with the DNA: while the first helix of this motif helps to stabilise the structure, the second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions, which occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. One particularity of the HTH motif in some of these proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the β-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 14 0.0007 0.21 11.9 0.3 4 49 15 60 13 62 0.95 2 14 0.1 30 5.0 0.1 26 54 138 166 122 168 0.85 3 14 0.016 4.7 7.6 0.1 15 56 186 227 179 228 0.92 4 14 0.0012 0.35 11.2 0.0 8 47 275 314 271 315 0.92 5 14 1.6e-11 4.6e-09 36.4 4.2 1 53 332 384 332 386 0.97 6 14 0.00014 0.042 14.1 0.2 27 55 458 486 454 488 0.90 7 14 3.2e-05 0.0095 16.2 0.0 6 48 544 586 542 588 0.92 8 14 4.2e-08 1.2e-05 25.5 0.1 5 52 607 654 606 657 0.96 9 14 4.6e-07 0.00014 22.1 0.9 11 52 689 730 680 731 0.94 10 14 0.0016 0.46 10.8 0.2 13 54 816 857 808 860 0.92 11 14 4e-15 1.2e-12 47.9 0.2 9 53 877 921 871 923 0.95 12 14 1.8e-08 5.4e-06 26.6 0.0 8 53 1057 1102 1054 1106 0.91 13 14 3.1e-09 9e-07 29.1 0.1 2 53 1177 1228 1176 1230 0.97 14 14 3e-09 8.8e-07 29.1 1.0 7 54 1245 1292 1243 1293 0.96
Sequence Information
- Coding Sequence
- ATGTACTATGTACATTTCTTCGCAGGTTACCAAGGGAATGCTCGTTTTGTTTTGAACACGAATCAGTTGATGCAGCTTCGACGATTGTCCTCCGATAAGAAGAGTCTCACTGCTGCCGAACTAAATACCATAGCCGAAGTATCGAAACTATCTTACGCAAATTGTCGTTTGTGGTATCAGCAGAACGGCGTTGTTGTTCCCCCCGAAGTAAAATCGGATGCGACTCGTGTGAAAGTTGAGGAAAGAAACGTCAAAGTGGGCTTCGCAATTATTGAAAAACATGGTAATCTAAGCGATTCGCAAAGACGCGCCAAGATGTTTATGTCTTCTCAGAGGCGCTCTTTCTTTTACAACCTTCCCTACGAAGATCAATTGTATCTGTTACGTAAGACTGAACACATGACATCGACGTCACATCAGCTAGCTGAAGAGATGAGCCTCAAATTGAAATTACCCGTAGATAAAATTTCCGCGTGGTTGAAACAACGGCGCAAACgcattttgaaagttgaagctGACTCCGACGTGAAAGTTTCGAATGTGAAATCAATTTTGCTCTGCGCCGAATTCGCTTGCGACAAAGAAATTGACGAAGATAAAGCTCTCATTCTCGCTTTCTGGTTCAACCTTTCGAAAAAAGCCATTTTAGGTTGGTACAAGAAGCAACAAGCGCAGTACAGATTTCGCGAAAAACAGAAAGCAACGAAAGATGTCGTCGTCGAGGACAAACCGAAACCAACAGCCATAAAAGTTGATAGCTCTAAATTACCGGTGGTATCATTTTCTAAAACCGAGGAGGACCTTTACGGTAATCAGAAAAAAACGCCGGCGCAACTTAATGTGCTTTTCGAAGCGTTCAAAAAGTATTCCGGTAAATTATACTCTCACATCGACGAACTCGCGAAACAAACCGGTCTAAGTGAGGGCGCAGTTCGTGATTGGATCGGCAAAACAAACGGCGTCTTGCGAACAAAAACAATGACCACGGTTACGAAAAAACTACGCGAGAATTTTACAACCGCCCAAGTGCGCGCATTGCAAAAAGAATATCGTAAACGAAAATACATTACTCGCAATGAAGCCAATGAAATCGCCTTGTCCACGAACCTGAATTCTAGTAAGGTAATGCAGTGGTTCAACAGTCGCAGAGTGCATGAACTCTTTTCGCACTATCCATCGTCCGcgtcaaaaaatggaaattcggGTCAACATATTACAGAAAGGGAGACGTCGCCGCCGCCGCCCCCGGACTCAGGTATGAGTCGCGTGGTCATTCAGAAGTCGTCGAGCAAACGACGCGGCAATCGAGGCAATGGCATTCCCGCCTTCAAAGTGTTACGTCTGTTGAAGGATCGTCGACGGTGCGGAAATAAAAAAGCTTTCTCTAAATTGGCCAAAGAACTCGGTTTACACGAGAAGCAGATAAGTTCTTGGCTAAGAAATAAGCAGTACCGAGAACAGATGATACATCGTGCTAAACTCGTGTACGGCGAAGCGTTGAAGGATCACGAGGATACCTCAACTGAAAATCGTCCTACTGCAAGTTCCAATCTTCTCGTCCAATTAACGAGTGATGAGGATTTGAAATCATCTTCGAACGAACCTATTCTCGCTTCGCCTGAAGATACAATGACGACGGGTATTCAACACTCCTGCTTATTCAACGCCTACAAAGAATCGAGAAGTTTGAGCGAAGCTCGCATTCAAGAGTTGAGTGATCGCTCAAATATGGacaagttgaaaataaaaaattggtgGAACGCGATAGGTAAGCATATGCGTCGAAAAAATATAGAGGTTCTCGAAACTTTTTTGATGACAAGCTGTAATGACGAACAacgtgaaaaattgattaactTGTATTCCAAAGCAAGGTACTATTCTAAAGCCTATCTAACGCGGATGGCCGAGCAGATCGGTATGAACTCAAAAACCGTTCATAGTTGGTTCATTAATGCGCGTCTTTATGAATTAAAAACTGGCGCAAAATTCAAGAGAACATCGACCTCACATAGTGACGTAGCCTGTGAGGATACAGCCTTCACATCGAATTTGGCGTGGCCTGAAATTCAGAAATTGAAACAAGAATTCCAAAAGGACGCAACAATGACGGACGCACGCGCCAGGTCATTGGCGATTCGTCTGAAAGTTCAATgcgataaaataaaagaatggtTTGAGAACAGACAACAATTCATCACAGAATGCAGCGAGAAAATAACTGACGATCATACAAATGCAGGCAACAGTAGCAGTGTAGATTACGAAGTGACCGTTGAGGAGGAAGTTATTGACGCTGAACCAACGACTGGCAATAACGAGACTTTACCTTCGGTACTCGTTCGACTTCCAAAAATTACTCCTAACTCGTTGAATGCCCCTTCGTGTTCTGAAAATTTCACGAGCGCATCTCAAGAGACGCAAATCAATCATTCCCGTCCAAAAGAACTTCTTTTCAAAGAGTTTCTTAAAGGATCGCGATTAACACCAGCGCGTTTGCAGCAGATTGCCTATGCCTCAAACATGGATCAAAAGCACATTTGTAAGTGGTTCAGTTGGTTGCGCTCAAAAGTGGCCAAACTCTCTGAAGACGTGCTCTCCGACAATTACCGTAATGAGAATTTAATTGACGAGCAAGTAAATGTTCTTGAAAGTGAGTTCCTAGTTACTCCTTATCCTGATCAGGAGACGAAAGAGACATTAAGCCAGCAATTGGGTGTATCTCGCGCTGTAGTGAAAACGTGGTTCGCTAATCGGAGATACTATGAAATATTGACAAATAGCGTTGTACCCGCATTTTCTGTTCCTACTATGTCTAAACTTGGTGTGGACTTCAAACCAGTCATCACATCTATATCGAGTGCCAAACAATTAAGCAATGAAATTCACGTGCATGGTGAAGAAGGGGTGCCATTTGATTCAGAGTCAATAGAGCGTGATGAATTATTAAACTCGTACGAGTTTAGTTCGCTAGACTTTGATAGGATAGATGTTCTGATGACAGAAGAACCTCAATTGGAATGTGCCCCCCTTTCATCATCGAGTCGTTTGCGTTACTTCGAACCATTGAATGAAAATCTCGAGCCGAGTATGTCAGAGAATCTGGATAATCTGTTTTGGTACATGAGTAGCTGTCCGAGCAAAGGCCTCGATAGCTCATCCGATCTATCAGAAGCCGATATTGTCGTCTTGGAGGGCATGTACGAGAAATGTCCGAAACCAACGCTCACCAAGATACATGAATTCGCGAAACGACTTCTGGTGAGTGAACAGGTCGTTTACTGGTGGTTTGTTCAACGTCGCAATCTTACAAAAATGGAGGAAACGCGCGACGGAAGTAAGGTTATTGTGATTTCGAGTCAGGAATTTGTGCCGAgtgatgaaattataaaatctgatttcaaagtttcgtctgaaaaatcagaaaaatactCTTGTAAAAATATCAGCGATTCTGTGGCCAACTCTCGTCAGTCAGATAGTACCAATAAGAATGAACTGTCAACATCCGCACGATTGGCTtcatgtaaaaagaaaaactcccTGTCCAGTCATCAGCGTTTAATTTTGTTAaacgaatttaaaaaattgaattttatatctcaatcaaaagccaaagctattGCCGCCGATATCGGCGTGCCTTTAAGAACTGTGAAGACGTGGTTCCATAAGCGGAGACAGCTTTTAAATATCGCCGAGCCAGCTAATTTAAAACCTATCACAGAAATGCTGAGCCCAAATCAACTCGTGACCTTGGAATTGGAATATCGTTCCGATCAAAAAGTGACAAAATTACGTCTACAAGAATTAGCTGCACGTTtgaatgtttctttgaagtccATAATCTTGTGGTTTAAAGAGCGAAAACAACAGACTGTTCAACTTGAAAAGCCGCAGCAATTGTCGGAAGTTATAAATGAGAATGTGCAGCCACTATCCAAAATGGAAGAATAa
- Protein Sequence
- MYYVHFFAGYQGNARFVLNTNQLMQLRRLSSDKKSLTAAELNTIAEVSKLSYANCRLWYQQNGVVVPPEVKSDATRVKVEERNVKVGFAIIEKHGNLSDSQRRAKMFMSSQRRSFFYNLPYEDQLYLLRKTEHMTSTSHQLAEEMSLKLKLPVDKISAWLKQRRKRILKVEADSDVKVSNVKSILLCAEFACDKEIDEDKALILAFWFNLSKKAILGWYKKQQAQYRFREKQKATKDVVVEDKPKPTAIKVDSSKLPVVSFSKTEEDLYGNQKKTPAQLNVLFEAFKKYSGKLYSHIDELAKQTGLSEGAVRDWIGKTNGVLRTKTMTTVTKKLRENFTTAQVRALQKEYRKRKYITRNEANEIALSTNLNSSKVMQWFNSRRVHELFSHYPSSASKNGNSGQHITERETSPPPPPDSGMSRVVIQKSSSKRRGNRGNGIPAFKVLRLLKDRRRCGNKKAFSKLAKELGLHEKQISSWLRNKQYREQMIHRAKLVYGEALKDHEDTSTENRPTASSNLLVQLTSDEDLKSSSNEPILASPEDTMTTGIQHSCLFNAYKESRSLSEARIQELSDRSNMDKLKIKNWWNAIGKHMRRKNIEVLETFLMTSCNDEQREKLINLYSKARYYSKAYLTRMAEQIGMNSKTVHSWFINARLYELKTGAKFKRTSTSHSDVACEDTAFTSNLAWPEIQKLKQEFQKDATMTDARARSLAIRLKVQCDKIKEWFENRQQFITECSEKITDDHTNAGNSSSVDYEVTVEEEVIDAEPTTGNNETLPSVLVRLPKITPNSLNAPSCSENFTSASQETQINHSRPKELLFKEFLKGSRLTPARLQQIAYASNMDQKHICKWFSWLRSKVAKLSEDVLSDNYRNENLIDEQVNVLESEFLVTPYPDQETKETLSQQLGVSRAVVKTWFANRRYYEILTNSVVPAFSVPTMSKLGVDFKPVITSISSAKQLSNEIHVHGEEGVPFDSESIERDELLNSYEFSSLDFDRIDVLMTEEPQLECAPLSSSSRLRYFEPLNENLEPSMSENLDNLFWYMSSCPSKGLDSSSDLSEADIVVLEGMYEKCPKPTLTKIHEFAKRLLVSEQVVYWWFVQRRNLTKMEETRDGSKVIVISSQEFVPSDEIIKSDFKVSSEKSEKYSCKNISDSVANSRQSDSTNKNELSTSARLASCKKKNSLSSHQRLILLNEFKKLNFISQSKAKAIAADIGVPLRTVKTWFHKRRQLLNIAEPANLKPITEMLSPNQLVTLELEYRSDQKVTKLRLQELAARLNVSLKSIILWFKERKQQTVQLEKPQQLSEVINENVQPLSKMEE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -