Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.089 98 5.2 0.2 84 108 2 26 1 28 0.91

2 4 0.013 14 7.9 0.1 77 108 27 58 25 60 0.89

3 4 4.4e-20 4.8e-17 64.2 0.0 8 99 119 210 112 222 0.87

4 4 0.14 1.5e+02 4.6 0.1 76 101 221 246 216 254 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.089	98	5.2	0.2	84	108	2	26	1	28	0.91
2	4	0.013	14	7.9	0.1	77	108	27	58	25	60	0.89
3	4	4.4e-20	4.8e-17	64.2	0.0	8	99	119	210	112	222	0.87
4	4	0.14	1.5e+02	4.6	0.1	76	101	221	246	216	254	0.80

Coding Sequence: ATGATGGACGTCTACCAGCTAGCCGTACAATTCAAGATGGAAAGACTTGAACACTTGTGCGTGCAATATTTGAACACAACGATTTGTCTCAATAATATCATCGAAGCATTAAAAAACGCTGATaaactaaaattggattttaTTAAAGAACACTGTTTAAGGTTTATAACAAAAGAGGCGAACTACAATCTAATAGTAATGGCTCCAGAATTCGAAACACTGGACAGCAAACTGATGGTCCAAATTATCAGACGAAAACAAATACCATATTCAAAGatcCACAACGAACACACGTTTGACCTGGCGGGCAATTCCCTGGAACAAGACATGCACAATTTCTTGCGCGTGACAGGCAAGGAATTCTGTGATATCGAATTAGTTTTAGATGGCAGCGTGACTCCCGCTCACAAGTCAATTTTGGCCGCCAGATGTGGCTATTTTGAAGCTATGTTCCGGTCGTTTATGCCGAGTGATAGTACTGTCAACATAAAAATTGGCGAGTTAACACCTTCCAAGGAATCATTTGATTCGCTACTCAGATATATTTACTACGGCGAAATAAAGATGCCTCCAGAGGACTCGCTATACCTATTTAGCTCCGCTTCGTTCTTCAACTTTACCAACGTCAGACTGCAGGCGTTCTGCAAACAAAATTTGGAGATGAACGTGACGTTTGAAAACGTAATTCAGATCTTGGAAGCAGCCGATAAGATGCAGGCGACAGATATGAAAAAGTACGCCTTGGATTTGATTGTGCATCACTTTACTAAGGTTGTTCGCTTGCCTCGTTTTAAAATGCTGGATAAACCGCTGATTTTGGATATTCTAGATGTTTTAGCCGAAAGTATGGATATTGATCAACGCAATGACGTGTCATCCACAGTGACCTTGAATCTGGATCCATGA
Protein Sequence: MMDVYQLAVQFKMERLEHLCVQYLNTTICLNNIIEALKNADKLKLDFIKEHCLRFITKEANYNLIVMAPEFETLDSKLMVQIIRRKQIPYSKIHNEHTFDLAGNSLEQDMHNFLRVTGKEFCDIELVLDGSVTPAHKSILAARCGYFEAMFRSFMPSDSTVNIKIGELTPSKESFDSLLRYIYYGEIKMPPEDSLYLFSSASFFNFTNVRLQAFCKQNLEMNVTFENVIQILEAADKMQATDMKKYALDLIVHHFTKVVRLPRFKMLDKPLILDILDVLAESMDIDQRNDVSSTVTLNLDP

Sequence clustering based on sequence similarity using MMseqs2