Basic Information

Gene Symbol
-
Assembly
GCA_017141405.1
Location
JADHZF010000026.1:2767065-2770636[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5.3e-13 4e-09 36.7 0.1 12 73 231 290 223 293 0.86
2 2 0.69 5.2e+03 -2.1 0.0 35 48 440 456 379 459 0.62

Sequence Information

Coding Sequence
ATGGAGGTTACTAATGCGAATGGCGGGAACGCTGAGGTGGCGCACACGAAATCTAACCTACAAGGTGTTGTCGAAACAAATCTGAAGATCGGAGTTACTCTTGATCAAGGGAAGTTGAAAGGTAACAAGAAAATGGACGGGGAAGAAGTAAATAGTGGTGATAAAAGTGTTAAAAAAAAGCCGATGAAAAGAAAGATGCGTAAGTCAAAGTCAAATTCTACGAGCAGTGTGGAAACTAATGCCAAACAAAAGGCTAGAGGAGTCAAGAGAAAATTATCGGATCCGTGTAGTTCTAATGATGAGGAATCGCAGGAGTTTCTTGGTTTTTCACCGGAGAGTGTTAACCTAATTGAGACAGAATTGCAAGTTATTCAGAAACTTATTGCTGACGCAGAATTGGAGACGAACTCTTCGAAACGTAAGCGCAGTTCCTCGAAAGCAACTCCAACGAATTTGGAGTCGAAATCAATCGTTGAACATGCTGAAAAAGTGACAATAACTGATGGTAAAACGAATTCCATTAATGTTGATGAAGGACTGAAACAAGAAGATGAAAAAGAAACGGAGAAAAAGGATGCAATTGTTATACCACATGCTTCGAAATCAGTTTCGAATAATGTGAACAGTGAGACCCCTTCAAGTGAAATTCCATCCGTAAACGCATCGAACAACTTGTATAAAGAGCCATTTAAATTTGGTTGGAGGCGTGAGGTGATATACAAGGGTGAAAGCAATAGTGCTCAGAAGAGAATCGCAGACATTTATTATTACTCTCCCAAGGGTAAGAAGGTTAAGAGCCTTCGAGAAGTCGCAGAGTGTTTGACAACAAAGGAGTTAACTTTAGATAATTTTACATTTTCTAAAGAATCCATTGGCGTTGAAGACCCGTCTCTGGAAATGATCACAGATACGAAAAAACCAAGATTAGAGTCAACAAATATTCAGGCTACACCTACAAAAAAATCTTCGAATAAGCGAGCGCCAATGGCTAAAGCGCTACTGACATCACCTCCAGGCTCACCCAAAATCGCTAAGACATCACCACCTAAAGCAACAACACCTGCTAGATTCAAAATTAAAGTCCCTGGAAAACGTGCAATGCAGAAAAAAGAAGTGAAACCATCCAAAGAATCAGAAATGGTGCCGCCCCAGTGGGCTTCTCCAACTGCAACGAGAAGAAGCCAAACAGTCGCTGATAAACTTACATCACCGAAAAATAAGAGGATATTAAAAGCTAAACTCCAGGAGCCCTGCAGTATTCGATGTTCACTGAGTATGGGACTGATACCAAGTCTCCAATGTCGCATTTGTCTATGTTTATATCATCCGGACTGTGTTGGTGGCAAAAAATTATCAACCAACAAGGAATACGTTTGCAAGGTATTATTGATAAGCAAAAATTGA
Protein Sequence
MEVTNANGGNAEVAHTKSNLQGVVETNLKIGVTLDQGKLKGNKKMDGEEVNSGDKSVKKKPMKRKMRKSKSNSTSSVETNAKQKARGVKRKLSDPCSSNDEESQEFLGFSPESVNLIETELQVIQKLIADAELETNSSKRKRSSSKATPTNLESKSIVEHAEKVTITDGKTNSINVDEGLKQEDEKETEKKDAIVIPHASKSVSNNVNSETPSSEIPSVNASNNLYKEPFKFGWRREVIYKGESNSAQKRIADIYYYSPKGKKVKSLREVAECLTTKELTLDNFTFSKESIGVEDPSLEMITDTKKPRLESTNIQATPTKKSSNKRAPMAKALLTSPPGSPKIAKTSPPKATTPARFKIKVPGKRAMQKKEVKPSKESEMVPPQWASPTATRRSQTVADKLTSPKNKRILKAKLQEPCSIRCSLSMGLIPSLQCRICLCLYHPDCVGGKKLSTNKEYVCKVLLISKN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-