Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.4e-23 1.8e-19 69.9 0.0 1 65 72 140 72 140 0.96

2 2 5.2e-20 3.9e-16 59.2 0.1 2 57 209 285 208 300 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.4e-23	1.8e-19	69.9	0.0	1	65	72	140	72	140	0.96
2	2	5.2e-20	3.9e-16	59.2	0.1	2	57	209	285	208	300	0.89

Coding Sequence: ATGTCCGATCAGGGAAGATGCACACCTGAACGAAAGGTGCTTGGAGAACTGAGCAATGTTAAAGAGCCAATATCACCTACAGCTAATCTAAGACTTTTAACGTCACTTGCTTCGAACCTCAAAAGTGCTGCTGATGCAAATAAACAAAGTGCAATTCAACGAAGAGATTCTCCCATCCCCTCCGGTTCTAATGGCTGTAAATTCCTGCCCAGGAAACAAAAGTCGTTGGGGTTACTATGCATTAAGTTTTTAAATATGTATCCTTTGAATGTGGAGCCAAGCGCTCCAAAAGAAATATCCCTGGATGGAACTGCGCGAGCCCTGGGAACAGAAAAGCGCCGAATTTATGATATAATAAACGTTCTCGAAAGTTTGGAAATGGCAGTAAAAGCTGGGAAAAATCGCTATCTGTGGCATGGCCAAAGTACTTTGGCTGAAACACTTACGAGACTGAAATCGATTGCAATTAGAATCGGTATGAAAGAGCAGATTCAGGAGATTCAGAGGACAAATAAGGCGTATACTGGGGAACACTGTGAAACATTATCCGGGCCCTCGGATCTAACAATGTCATTTGAGGAAATATCTGAGGAGGAAATGCTTGGGGATAATGTTATTAAAGAGGATAAAAGTCTGGGAGCTATGTGTCAAAAGTTTGTGATGCTGTTTCTTATTTCTATGAAGAATGGAGTAATAAATTTAGACATTGCTGCAAAAGTTTTAATTGGTGACGTGGACGATCAAACTCCTGAAATAGCTGACAACGCATCGAGGTGTCGTTCTAAAACCAAAGTACGACGTTTATATGACATTGCTAATGTTTTGACTGCAGTTGGACTAATTAAGAAGGTGCATATGGATGAAAGGACCATTAGGAAACCTATATTCAAATACGCTGGTCCGATAATTGGTACATCTGATACTGACACAGGTAAGACTCCAGATTTTCAGATTGATCCAGGGAGATTGCTTTCCAAACTGCGATTTAGATGTAAGGAGGTCGACCAAATGACCTTCATGTCAGGATAA
Protein Sequence: MSDQGRCTPERKVLGELSNVKEPISPTANLRLLTSLASNLKSAADANKQSAIQRRDSPIPSGSNGCKFLPRKQKSLGLLCIKFLNMYPLNVEPSAPKEISLDGTARALGTEKRRIYDIINVLESLEMAVKAGKNRYLWHGQSTLAETLTRLKSIAIRIGMKEQIQEIQRTNKAYTGEHCETLSGPSDLTMSFEEISEEEMLGDNVIKEDKSLGAMCQKFVMLFLISMKNGVINLDIAAKVLIGDVDDQTPEIADNASRCRSKTKVRRLYDIANVLTAVGLIKKVHMDERTIRKPIFKYAGPIIGTSDTDTGKTPDFQIDPGRLLSKLRFRCKEVDQMTFMSG

Sequence clustering based on sequence similarity using MMseqs2