Basic Information

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.9e-57 1.9e-53 182.1 1.3 7 320 1 303 1 306 0.78

2 2 1.1e-12 5.2e-09 35.7 0.1 360 408 307 355 302 356 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.9e-57	1.9e-53	182.1	1.3	7	320	1	303	1	306	0.78
2	2	1.1e-12	5.2e-09	35.7	0.1	360	408	307	355	302	356	0.95

Coding Sequence: ATGAGAGGAGGGAGGAATAAATTCGGCCCAATGTACAAAAGGGACAGAGCACGGAAGCTGCAGATAATGCGTCAACGGCAGCTTGCGGCGCAGACATTGAGAGGGGGCTCCTTGGGGGACGGCATGTACAGCAGCCAGCCAGGGACGTCACCATTTGCTAACATCCACATAAAACAAGAGATCCAGATTCCCCAAGTGTCATCTTTAACATCATCTCCCGACTCCTCTCCTAGCCCCATCGCCGTTGCTCTAGGTCAAGTGAACACATCCACATTAGTTCAACAAGCGTCCAACCAACAGCCGGCTCTCCAAATAGTCGGGGTACCTGGAGCGCCCACCTCCATGGTGATGGGACCCGACAACAAGCTGTGGGCCTCCGCCAACTCCACCACCACGTCGCCCCATTCTCTAAGTCCCAAAGCGTTCCAGTTTGATACGGTGGTACAAGGAAGTAGTGCTCCTCCCTCCAGTAAAGTGTCACCACTGATAAGAGACTTTGTGCAAGCGATTGATGATCGCGAGTGGCAAAACTCTTTATATACACTCCTGCAAAACCAAACATATAATCAATGTGAAGTGGACTTGTTTGAACTTATGTGTAAAGTTTTGGACCAAAATCTTTTCTCTCAAGTAGATTGGGCGAGGAATTCTGTCTTCTTTAAGGATCTCAAGgtgGATGACCAAATGAAATTGTTGCAACATTCGTGGTCAGACATGCTCGTTTTGGATCATATACACCAACGTATGCACAACAATCTTCCTGACGAAATGACTCTACACAACGgtcaaaaattcgatttattaaatttaggatTATTAGGAGTACCCAGTTTAGCAGATCACTTTAATGACATCACAGCCAAACTTCAAGAACTCAAATATGACatGTACGAGGcatcacaaataaaaaacatgtacAAAAAGGACAAGTTCAACAAGATGATGCAACTGTTGCCTGAGATCCACGGTTTGGCGGCGCGAGGCGAAGAACACCTCTACCAGAAACACTGCACAGGCAGCGCGCCGACACAAACGCTTCTCATGGAAATGCTCCACGCGAAAAGGAAA
Protein Sequence: MRGGRNKFGPMYKRDRARKLQIMRQRQLAAQTLRGGSLGDGMYSSQPGTSPFANIHIKQEIQIPQVSSLTSSPDSSPSPIAVALGQVNTSTLVQQASNQQPALQIVGVPGAPTSMVMGPDNKLWASANSTTTSPHSLSPKAFQFDTVVQGSSAPPSSKVSPLIRDFVQAIDDREWQNSLYTLLQNQTYNQCEVDLFELMCKVLDQNLFSQVDWARNSVFFKDLKVDDQMKLLQHSWSDMLVLDHIHQRMHNNLPDEMTLHNGQKFDLLNLGLLGVPSLADHFNDITAKLQELKYDMYEASQIKNMYKKDKFNKMMQLLPEIHGLAARGEEHLYQKHCTGSAPTQTLLMEMLHAKRK

Sequence clustering based on sequence similarity using MMseqs2