Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.0093 22 7.3 0.2 21 49 6 34 3 38 0.90

2 10 0.098 2.4e+02 4.0 0.3 18 44 32 58 31 64 0.82

3 10 0.76 1.8e+03 1.2 0.4 21 44 64 87 60 92 0.75

4 10 0.089 2.2e+02 4.1 0.3 21 48 93 120 88 122 0.90

5 10 0.004 9.5 8.5 0.3 17 48 118 149 105 154 0.84

6 10 2 4.7e+03 -0.2 0.5 21 30 151 160 147 178 0.82

7 10 0.00017 0.4 12.9 0.2 21 51 180 210 167 213 0.90

8 10 0.49 1.2e+03 1.8 0.0 23 48 211 236 209 239 0.88

9 10 0.00036 0.86 11.8 0.5 17 48 234 265 229 267 0.92

10 10 0.001 2.5 10.3 0.6 18 48 264 294 263 298 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.0093	22	7.3	0.2	21	49	6	34	3	38	0.90
2	10	0.098	2.4e+02	4.0	0.3	18	44	32	58	31	64	0.82
3	10	0.76	1.8e+03	1.2	0.4	21	44	64	87	60	92	0.75
4	10	0.089	2.2e+02	4.1	0.3	21	48	93	120	88	122	0.90
5	10	0.004	9.5	8.5	0.3	17	48	118	149	105	154	0.84
6	10	2	4.7e+03	-0.2	0.5	21	30	151	160	147	178	0.82
7	10	0.00017	0.4	12.9	0.2	21	51	180	210	167	213	0.90
8	10	0.49	1.2e+03	1.8	0.0	23	48	211	236	209	239	0.88
9	10	0.00036	0.86	11.8	0.5	17	48	234	265	229	267	0.92
10	10	0.001	2.5	10.3	0.6	18	48	264	294	263	298	0.92

Coding Sequence: ATGGCctgtcatacaggtgagaagcctcatcactgtcctcactgtgattataaatcagcacaatctggacacatgaaaaatcatgtaatggcccgtcatacaggtgagaagcctcatcaatgtcctcactgtgattataaatcagcacaatctggagctatgaaaatacatgtaatggcctgtcatacaggtgagaagcctcatcaatgtcctcactgtgactTTAAATCAGCAAGgtctggacaaatgaaaaatcatgtaatggcctgtcatacaggtgagaagcctcatcaatgtcctcactgtgactTTAAATCAGCAAGgtctggacaaatgaaaaatcatgtaatggcccgtcatacaggtgagaagcctcatcaatgtcctctcTGCGATTATAAAACAGTAACATCTGGAGCTATGAAAAGGCATGTAATGGCctgtcatacaggtgagaagcctcatcagtgccctcactgtgattataaatcagcctTATCTGGAACCATGAAAATACATGTAATGGCctgtcatacaggtgagaagcctcatcactgtcctcactgtgattataaatcagcacaatcTGGAGATATGAAAAGACATGtgatggcccgtcatacaggtaagaagcctcatcaatgtcctcactgtgattataaatcagcagaaTCTGGAGCTATGAAAAATcatgtaatggcccgtcatacaggtgagaagcctcatcactgtcctcactgtgattataaatcagcacaatcTGGAACTATGAAAAGACATGTTATGGCCCggcatacaggtgagaagcctcatcaatgtcctcactgtgattatacaTCAGCAGAATCTGGAAAGATTAAAAGACATATAATAGTCCGTCATAAAGGGGAGAAACGTCATCAATGTCCTCTCTAA
Protein Sequence: MACHTGEKPHHCPHCDYKSAQSGHMKNHVMARHTGEKPHQCPHCDYKSAQSGAMKIHVMACHTGEKPHQCPHCDFKSARSGQMKNHVMACHTGEKPHQCPHCDFKSARSGQMKNHVMARHTGEKPHQCPLCDYKTVTSGAMKRHVMACHTGEKPHQCPHCDYKSALSGTMKIHVMACHTGEKPHHCPHCDYKSAQSGDMKRHVMARHTGKKPHQCPHCDYKSAESGAMKNHVMARHTGEKPHHCPHCDYKSAQSGTMKRHVMARHTGEKPHQCPHCDYTSAESGKIKRHIIVRHKGEKRHQCPL

Sequence clustering based on sequence similarity using MMseqs2