Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 8.1 3.2e+03 -1.3 0.1 81 105 96 120 56 134 0.58

2 4 9.9 4e+03 -1.6 0.0 49 69 150 169 144 171 0.71

3 4 3.1e-18 1.3e-15 58.0 0.4 9 109 172 272 164 273 0.89

4 4 0.0012 0.47 11.1 0.1 78 109 273 304 269 305 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	8.1	3.2e+03	-1.3	0.1	81	105	96	120	56	134	0.58
2	4	9.9	4e+03	-1.6	0.0	49	69	150	169	144	171	0.71
3	4	3.1e-18	1.3e-15	58.0	0.4	9	109	172	272	164	273	0.89
4	4	0.0012	0.47	11.1	0.1	78	109	273	304	269	305	0.91

Coding Sequence: ATGGACATCGATATGAAGGAAAACAGTGTGATTCAGGGGCATCAAATGTGCCAGACTGAGGATGCCAGTTGGCTGTGCTTGGATAACATTTACATGAAGTTTCACAGACCCAACATATATGACATTGGAGGCACAAATATTGACCACATAGCGGATTACTGGTTTCTCATGCAAACGGAGCAAGTGGGGAAAGTGTTTCTGCTACATATTTTCATCATGAATCGACACGAAAGTACATTTACAGTGTCAATTAGCGCTAATAATGAGCTAACATTCAACAAAAGGCATAACTTTGCACACTTGACTACAAATCTAGAAAAATATTCTTTTAAAAATGTTGATGAAATGGTGCAAAACTATCTCACCACATACAGCTTCACAAGTATAGATGTAGAGTCCTTAAGAAATTATAAGCTGTACATACCCATATCATTCGATCACTTTGATCAAGATAACTCATCTATTGATAGCAATATGCCATTTCATGATTTTGAAACATTGCTGAAGGATCCTGTGGGAGCGGATTTTACAATAGAATCAGCCGATGGGGAGAAATTTAAAGTTCATAGAATACTGCTAACATCCCTTTGCGAGGTGTTCAAGGCAATGTTAAAGGAGGACACAGCCGAGAGTCAAAATGGCTTTGTGAAACTAGTGGATGTAAGCAAGGAAGATCTCAGCTGTATAGTTGAATTCATCTACACTGGCACAGTAAAGGATATAGAAAACAATAATTTCTTTAGTCTACTTATGTTGGCCGATAGATATGATCTGAAGGGTTTGAAAGAGCTGGCAGAGATTGTTCTTTCAAATCAGTTGTCGTCGGAGAATGTTTTAGAAATTTTAGCTGTGGCAGATTTGTACAACTCCCAGCACTTAAAAACTGCCTCCATGAAGTTTTTGAAACAAAACCCAACCGCAATACACAGCAGTATGTTCAGTGAGCTAAAGAATGTTGAGTTGGTGCAGGAACTGTGTAAATTTATGATTCCACAGTAG
Protein Sequence: MDIDMKENSVIQGHQMCQTEDASWLCLDNIYMKFHRPNIYDIGGTNIDHIADYWFLMQTEQVGKVFLLHIFIMNRHESTFTVSISANNELTFNKRHNFAHLTTNLEKYSFKNVDEMVQNYLTTYSFTSIDVESLRNYKLYIPISFDHFDQDNSSIDSNMPFHDFETLLKDPVGADFTIESADGEKFKVHRILLTSLCEVFKAMLKEDTAESQNGFVKLVDVSKEDLSCIVEFIYTGTVKDIENNNFFSLLMLADRYDLKGLKELAEIVLSNQLSSENVLEILAVADLYNSQHLKTASMKFLKQNPTAIHSSMFSELKNVELVQELCKFMIPQ

Sequence clustering based on sequence similarity using MMseqs2